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University of Liverpool Biotechnology PhD Projects, Programs & Scholarships

We have 13 University of Liverpool Biotechnology PhD Projects, Programs & Scholarships

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  ’Mechano-culture’ of stem cells for tissue engineering and regenerative medicine
  Dr JR Henstock
Applications accepted all year round
OVERVIEW. The core objective of the PhD is to develop a new pneumatic (hydrostatic) pressure bioreactor for manufacturing mesenchymal stem cells.
  Developing and applying computational methods to understand the genetics of ageing
  Dr JP de Magalhaes
Applications accepted all year round
Ageing is the chief biomedical challenge of the 21st century, yet it remains a major puzzle of biology. Although it is clear that the process of ageing has a strong genetic component, much work remains to elucidate how the genome regulates ageing.
  Diabetic osteoarthritis : Investigating its causes and discovering interventions using tissue engineered human cartilage
  Dr JR Henstock
Applications accepted all year round
OVERVIEW. People with diabetes have more than twice the risk of developing osteoarthritis than the general population.
  Optimisation of techniques for improving the storage of osteochondral allograft tissue
  Dr R Oldershaw, Dr PI Milner, Dr M Phelan
Applications accepted all year round
We will investigate the biochemical properties of living human articular cartilage tissue so as to optimise the conditions for storing osteochondral allograft tissue used in transplantation.
  Targeting ageing: Genes and compounds with pro-longevity, health-preserving effects
  Dr JP de Magalhaes
Applications accepted all year round
Ageing is arguably the major biomedical challenge of the 21st century. In model organisms, the process of ageing can be manipulated by both genetic manipulations and dietary interventions.
  Characterising and repurposing cyanobacterial CO2-fixing organelles for metabolic engineering
  Dr LN Liu, Dr J Hartwell
Applications accepted all year round
Compartmentalisation represents an effective strategy used by cells to enhance their activities. By creating physical barriers and compartments, cells sequester the metabolic pathways from the cellular milieu to allow controls of metabolic flux and toxic diffusion.
  Development of metabolomics for understanding AMR in mixed infections
  Prof R Goodacre
Application Deadline: 28 February 2019
Without correct antibiotic stewardship we could be cast back to a pre-infective era where we have run out of antibiotics to treat life-threatening infections.
  Evolutionary insights for engineering improved globin oxygen carriers
  Dr M Berenbrink, Dr J Madine
Applications accepted all year round
Around 2 million red blood cell units at a cost of 120.00 GBP per unit are transfused annually in England alone (http://www.nhsbt.nhs.uk/what-we-do/blood-transfusion/).
  Exploring Stem Cell Regulation by Heparan Sulphates using Chemical Biology and Glycomics Strategies
  Prof J E Turnbull
Applications accepted all year round
Heparan sulphates (HS) are complex sulphated polysaccharides expressed at the cell surface. They are essential co-receptors for many proteins, most notably many signalling growth factors, and they act as dynamic regulators of protein function.
  Understanding and dissecting microbial communities with Raman spectroscopy
  Prof R Goodacre
Application Deadline: 28 February 2019
We have shown that it is possible to label bacteria with heavy isotopes of carbon (13C) and nitrogen (15N) and this incorporation within cellular biomass of heavy isotopes has led to significant shifts in certain vibrational modes from amino acids and nucleic acids that can be readily detected with Raman spectroscopy.
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