Tumour cells are long known to appear in vastly diverse shapes, both across patients and within a single tumour. This is in stark contrast to the regularity of cell shapes of healthy epithelial tissues from which most tumours originate.
Cancer rarely kills through the primary tumour in which cancer arises, e.g. the prostate in prostate cancer. Instead, cancer cells may travel through the vasculature and colonialize distant organs – a process termed metastasis.
Position for a PhD student is available in the group of Dr Pawel Grzechnik at the University of Birmingham. The aim of the project is to understand how eukaryotic cells remodel RNA biology in order to survive stress generated by pathological conditions and external stressors.
Our recent work provided the first insights into the mechanism of replication machinery (replisome) unloading at the termination of DNA replication, making use of Xenopus laevis egg extract, which provides a simple cell-free system that recapitulates DNA replication.
Our recent work provided the first insights into the mechanism of replication machinery (replisome) unloading at the termination of DNA replication, making use of Xenopus laevis egg extract, which provides a simple cell-free system that recapitulates DNA replication.
Prostate cancer is one of the most common types of cancer in men and claims over 350,000 lives worldwide every year. Early and accurate detection is critical to improve patient survival.
Prostate cancer is one of the most common types of cancer in men and claims over 350,000 lives worldwide every year. Early and accurate detection is critical to improve patient survival.
Applications are invited for a 3-year fully-funded PhD studentship starting in October 2019, supervised jointly by Dr Daniel Tennant and Professor Colin Watts.