Genetics PhD Projects, Programs & Scholarships in Birmingham
We have 14 Genetics PhD Projects, Programs & Scholarships in Birmingham
We have 14 Genetics PhD Projects, Programs & Scholarships in Birmingham
Identification of novel regulators of pancreatic beta-cell identity
Diabetes is the largest epidemic in human history that affects 1 in 12 adults worldwide. Due to our modern lifestyle, it is one of the few diseases where the incidence is set to rise dramatically, with projections putting 650 million people at risk by 2040. Read more
Identification of novel accessory Sec components in bacteria using high-throughput methods
Every compartment of a cell contains proteins, and yet all of these proteins are initially synthesised inside the cell in the cytoplasm. Read more
Exploiting rare polymorphisms, structural variation, and germline-somatic mutation interactions to explain missing heritability in cancer development.
Understanding cancer heritability has an enormous impact on disease prevention, early detection and tailored treatment. GWAS based on single nucleotide polymorphisms only explain a modest fraction (2-15%) of heritable variation in cancer risk (McCarroll, 2008). Read more
Determining novel molecular regulators of necrosis controlling premature cell death
Necrosis, a form of premature cell death, is frequently caused by excessive insults such as trauma, infection and toxins. It has been implicated in many human diseases including cancer, neurodegenerative disorders and inflammatory diseases. Read more
Regulation of apoptosis-induced compensatory cell proliferation and its implications for cancer and tissue regeneration
In multi-cellular organisms, coordinated cell death (e.g. apoptosis) and cell replacement is critical for tissue recovery in response to stress or damage. Read more
Investigating the effects of large-scale genome instability in cellular stress response and cell-microenvironment interactions
Genome instability enables organisms to evolve diverse phenotypic traits to survive adverse environments by acquiring adaptive genetic alterations. Read more
mRNA epigenetics: Charaterization of a novel layer of gene regulation for essential brain functions
Research Group:
BBSRC MIBTP
For over 40 years we know about modified nucleotides in mRNA, but the functions for these essential modifications are largely elusive. Read more
Molecular genetic characterization of Drosophila reproductive behaviours for exploitation in insect population control
Research Group:
BBSRC MIBTP
Female reproductive behaviours in most insects profoundly change after mating leading to rejection of courting males and induction of egg laying. Read more
BBSRC MIBTP - Identification of pathways deregulating neuronal ELAV/Hu RNA binding proteins and alternative splicing in neurodegeneration
Research Group:
BBSRC MIBTP
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions. Read more
Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam
Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response. Read more
Dissecting mechanisms that control adult stem cells in health, disease, and ageing
Adult organs are maintained by specialised stem cells that persist throughout life thanks to their ability to make exact copies of themselves, all the time retaining the ability to on demand produce the differentiated component cells of the tissue of which they are a part. Read more
Dissecting the role of novel haematopoietic factors in development and disease
Blood is made up of different cell types with different functions, such as carrying oxygen (red blood cells), help with wound healing (platelets) and fighting infections (white blood cells). Read more
Investigating the impact of lysine methylation in neuronal DNA repair
Our genomic DNA is under constant attack from DNA damaging agents, which are a continuing threat to genomic integrity. Defective resolution of DNA damage underlies several human diseases, including neurological abnormalities and developmental disorders as well as cancer. Read more
Investigating the role of lysine methylation in the DNA damage response.
Our genomic DNA is under constant attack from DNA damaging agents, which are a continuing threat to genomic integrity. Defective resolution of DNA damage underlies several human diseases, including neurological abnormalities and developmental disorders as well as cancer. Read more
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