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Genetics PhD Projects, Programs & Scholarships in Birmingham

We have 23 Genetics PhD Projects, Programs & Scholarships in Birmingham

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Showing 1 to 10 of 23
  Profiling stem cell epigenetic transitions within the Drosophila hematopoietic stem cell niche
University of Birmingham Institute of Immunology and Immunotherapy
  Dr P Badenhorst
Applications accepted all year round
The self-renewal and differentiation of stem cells is controlled by signals derived from the microenvironment or “niche”. The paired hematopoietic organs of the Drosophila genetic model organism are a well-characterized system in which the regulation of stem cell behaviour within a niche can be genetically dissected.
Details
Type/Funding
  Transcriptional responses to cellular stress
University of Birmingham School of Biosciences
  Dr PG Grzechnik
Applications accepted all year round
Position for a PhD student is available in the group of Dr Pawel Grzechnik at the University of Birmingham. The aim of the project is to understand how eukaryotic cells remodel RNA biology in order to survive stress generated by pathological conditions and external stressors.
Details
Type/Funding
  Analysis of pathogen determinants recognized by the hypervariable immune receptor Dscam
University of Birmingham School of Biosciences
  Dr M Soller
Applications accepted all year round
Background. To mount an immune response, host organisms must first recognize the pathogen with which they are infected. The first line of defense against pathogen infection in animals is provided through the innate immune response.
Details
Type/Funding
  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
University of Birmingham School of Biosciences
  Dr M Soller, Dr T Knowles
Applications accepted all year round
Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
Details
Type/Funding
  mRNA epigenetics: Charaterization of a novel layer of gene regulation for essential brain functions
University of Birmingham School of Biosciences
  Research Group: BBSRC MIBTP
  Dr M Soller, Dr PG Grzechnik
Applications accepted all year round
For over 40 years we know about modified nucleotides in mRNA, but the functions for these essential modifications are largely elusive.
Details
Type/Funding
  Molecular genetic characterization of Drosophila reproductive behaviours for exploitation in insect population control
University of Birmingham School of Biosciences
  Research Group: BBSRC MIBTP
  Dr M Soller
Applications accepted all year round
Female reproductive behaviours in most insects profoundly change after mating leading to rejection of courting males and induction of egg laying.
Details
Type/Funding
  BBSRC MIBTP - Identification of pathways deregulating neuronal ELAV/Hu RNA binding proteins and alternative splicing in neurodegeneration
University of Birmingham School of Biosciences
  Research Group: BBSRC MIBTP
  Dr M Soller, Dr M Tomlinson
Applications accepted all year round
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions.
Details
Type/Funding
  Regulation of autophagy in human embryonic stem cells and its therapeutic application in induced pluripotent stem cell-based disease models
University of Birmingham Institute of Cancer and Genomic Sciences
  Dr S Sarkar
Applications accepted all year round
Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
Details
Type/Funding
  Methods for quantitative genetic analyses in autotetraploids
University of Birmingham School of Biosciences
  Prof Z Luo
Applications accepted all year round
Methods for quantitative genetic analysis have been well established in almost all important diploid plants and animal including humans, and have served as essential tools for dissecting the genetic architectures underlying agronomically, evolutionarily and medically interesting quantitative and complex traits.
Details
Type/Funding
  Neural basis underlying mating decisions in fruit flies
University of Birmingham School of Biosciences
  Dr C Rezaval
Applications accepted all year round
Mate choice is an essential behavioural process with profound consequences in evolution. How do animals choose with whom to mate? How do they evaluate the features of a potential mate to maximise their reproductive success?.
Details
Type/Funding
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