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We have 21 Bioinformatics PhD Projects, Programmes & Scholarships in Bradford
Bioinformatics PhD Projects, Programmes & Scholarships in Bradford
We have 21 Bioinformatics PhD Projects, Programmes & Scholarships in Bradford
Integrated omics approach to psychiatric disorders
Research Group:
Chemistry and Biosciences
In psychiatry, the selection of antipsychotics and antidepressants is led by a trial-and-error approach. The prescribing of these medications is complicated by sub-optimal efficacy and high rates of adverse drug reactions (ADRs). Read more
Haematology: Oncogenic mechanisms causing malignant transformation of B cells and plasma cells
Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Read more
Molecular mechanisms of pacemaker (sinus node) dysfunction in ageing, heart failure and athletes
Research Group:
Chemistry and Biosciences
The heart’s pacemaker, the sinus node, initiates the action potential that causes the heart to beat, and the atrioventricular node conducts the action potential from the atria to the ventricles, the pumping chambers of the heart. Read more
Responsible AI for Health and Social Care
The increasing adoption of Artificial Intelligence (AI) technologies that could impact humanity raises increasing concerns from general public, industry and regulatory bodies. Read more
Translational Medicine: Understanding the mechanism(s) of resistance to EPA to personalise therapy and improve outcome
Advanced colorectal cancer (CRC) is the UK’s second most lethal cancer, with limited treatment options for unresectable metastatic tumours. Read more
Genetics: Investigating the molecular basis of optic nerve degeneration in glaucoma to try and develop a personalized medicine strategy for treatment
The optic nerve is a special sensory nerve that transmits visual impulses from the retina to the brain. Primary Open Angle Glaucoma (POAG) is a chronic, progressive optic neuropathy of multifactorial origin that affects 1 in 10 elderly individuals. Read more
Genetics: Genetic studies of developmental eye disorders to investigate genotype-phenotype correlations
Developmental eye defects that affect the front of the eye give rise to a spectrum of congenital ocular phenotypes that affect the cornea, lens, iris, trabecular meshwork or the globe itself. Read more
Control and inhibition of virus replication
The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specifically Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets. Read more
Elucidating the molecular mechanisms of intrinsic antibiotic resistance in bacterial pathogens
Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to the average human lifespan. Read more
Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents
Research Group:
Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more
Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems
Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more
Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain
The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more
Cancer Biology: The role of Wnt signaling in glioblastoma therapeutic resistance
Glioblastoma is a deadly brain tumour treated with surgery, radiotherapy and chemotherapy with patient survival of 6-15 months. Read more
Clinical: Adherence with Cancer Treatment in Adolescents and Young Adults
Adherence with therapy is a significant clinical problem in young people, for many reasons. The scale of this has never been quantified in a population-based setting. Read more
Genetics: Unravelling the Norrin/beta-catenin signaling pathway and its role in retinal angiogenesis and blindness
Our previous work on the genetic analysis of individuals with the inherited retinal disease Familial Exudative Vitreoretinopathy (FEVR), has helped identify a new angiogenesis pathway, the Norrin/beta-catenin pathway. Read more
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