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We have 29 Cancer Biology PhD Projects, Programmes & Scholarships in Bradford

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Biological Sciences

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Bradford  United Kingdom

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Cancer Biology PhD Projects, Programmes & Scholarships in Bradford

We have 29 Cancer Biology PhD Projects, Programmes & Scholarships in Bradford

Targeting the MAPK scaffold protein KSR1 for the treatment of prostate cancer

  Research Group: Institute of Cancer Therapeutics
Prostate cancer is one of the leading causes of male cancer deaths. It arises when individual cells escape their normal growth control mechanisms and proliferate in an uncontrolled fashion. Read more

Nanoparticle synthesis and application in magnetic field hyperthermia for cancer therapy

  Research Group: Chemistry and Biosciences
Magnetic field hyperthermia (MFH) is currently undergoing clinical trials for use in humans. The research to date has shown the effectiveness of the approach in cells and animal models and the initial results from human trials are promising. Read more

Investigation of novel PARP7-targeting agents for the treatment of cancer

PARP7, an ADP-ribosyltransferase, modulates protein function by adding an ADP-ribose moiety to target proteins. It is involved in many physiological and pathophysiological processes such as neural development, maintenance of stem cells, immunity, xenobiotic metabolism, immunity and cancers. Read more

Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

New molecules and mechanisms in angiogenesis

The School of Molecular & Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

A bifunctional prodrug to overcome acquired oxaliplatin drug resistance in colorectal cancer

  Research Group: Institute of Cancer Therapeutics
This is one of two new fully funded PhD studentships in the Institute of Cancer Therapeutics Doctoral Training Centre (ICT-DTC) at the University of Bradford. Read more

Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

  Research Group: Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more

Polysialyltransferases as a target in metastatic cancer

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more

Computational and machine learning driven development of new polysialyltransferase (ST8SiaII) inhibitors against metastatic cancer

  Research Group: Institute of Cancer Therapeutics
Polysialic acid (polySia) is a carbohydrate polymer important for embryonic development. PolySia is absent in healthy adult tissues whereas overexpressed in several tumours. Read more

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

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