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Cell Biology / Development PhD Projects, Programs & Scholarships in Bradford

We have 65 Cell Biology / Development PhD Projects, Programs & Scholarships in Bradford

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  Molecular, biochemical and developmental analysis of root traits for low P adaptation in foxtail millet.
  Research Group: Centre for Plant Sciences
  Prof A Baker, Dr S Kepinski
Application Deadline: 8 January 2020

Funding Type

PhD Type

Phosphorus is an essential macronutrient for plant growth and cannot be replaced by any other element. It is the second most limiting nutrient after N.
  Epigenetic sensing of temperature in plants
  Research Group: Centre for Plant Sciences
  Prof B H Davies, Prof A Whitehouse, Dr J Aspden
Applications accepted all year round

Funding Type

PhD Type

Our changing climate is already having a dramatic effect on the growth and development of the plants that support our entire civilisation.
  The roots of yield: coordination of shoot growth with soil environment
  Dr T.A. Bennett
Application Deadline: 8 January 2020

Funding Type

PhD Type

Plants are able to sense a large number of rhizospheric stimuli including the availability of nitrate and phosphate, soil volume and depth, and the presence of neighbouring plants.
  An integrated approach to the study of cellular interactions with amyloid
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford
Applications accepted all year round

Funding Type

PhD Type

The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
  Investigating the mechanism of action of dual antiangiogenic/ antineoplastic drugs using organotypic co-culture of fibroblasts and endothelial cells
  Research Group: Institute of Cancer Therapeutics
  Dr J Elies Gomez, Dr K Pors
Applications accepted all year round

Funding Type

PhD Type

An important feature of many types of cancer is the ability to develop abnormal angiogenesis (blood vessel formation); this allows cancer cells to gain access to nutrients and favours metastasis.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Dr J Boyes
Application Deadline: 25 January 2020

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  MRC DiMeN Doctoral Training Partnership: Developing protein tools to target DNA damage response and repair in cancer cells
  Dr Q. Wu, Dr D Tomlinson
Application Deadline: 6 January 2020

Funding Type

PhD Type

DNA damage response (DDR) and repair play critical roles in influencing the efficiency and sensitivity of many cancer treatments.
  MRC DiMeN Doctoral Training Partnership: Understanding proteotoxicity of alpha- and gamma-synuclein in neuronal C. elegans models of neurodegeneration
  Dr P van Oosten-Hawle, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

Synucleopathies, such as Parkinson’s Disease (PD), are neurodegenerative diseases characterised by the accumulation of alpha-synuclein (asyn) aggregates into Lewy Bodies in neurons, leading to toxicity and cell death.
  MRC DiMeN Doctoral Training Partnership: Systems-level understanding of calcium dynamics in cardiac cells, and functional effects of their modification in heart failure
  Dr M.A. Colman, Dr A.P. Benson
Application Deadline: 6 January 2020

Funding Type

PhD Type

The mechanical function of the heart is driven by electrical activity through the process of excitation-contraction coupling. Intracellular calcium (Ca2+) signalling is a critical component of this coupling.
  MRC DiMeN Doctoral Training Partnership: Relating skeletal muscle oxygenation dynamics to exercise intolerance mechanisms in heart failure: patient-specific interpretation of near infrared spectroscopy measurements
  Dr A.P. Benson, Dr C Ferguson, Prof S Egginton
Application Deadline: 6 January 2020

Funding Type

PhD Type

Heart failure is a complex clinical syndrome, the principal symptom of which is profound exercise intolerance (an inability to perform even day-to-day activities), the severity of which relates to disease severity.
  Control and inhibition of virus replication
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A.K Tuplin
Applications accepted all year round

Funding Type

PhD Type


The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specificaly Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets.
  MRC DiMeN Doctoral Training Partnership: Dissecting the function of long non-coding RNAs during neuronal differentiation and neuronal diseases
  Dr J Aspden, Dr G Hautbergue, Dr J Fontana
Application Deadline: 6 January 2020

Funding Type

PhD Type

Whilst 85% of our genome is transcribed, only 4% is protein-coding. In fact, many non-coding RNAs exist, some of which are similarly processed to mRNAs, termed long non-coding RNAs (lncRNAs).
  MRC DiMeN Doctoral Training Partnership: From atoms to organoids: understanding how abnormal cilia cause a neurodevelopmental disorder
  Dr T Ochi, Prof CA Johnson
Application Deadline: 6 January 2020

Funding Type

PhD Type

Eukaryotic primary cilia are the “antennae” of eukaryotic cells that detect and integrate a wide variety of environmental signals essential for photosensation in the eyes, chemosensation in the nose, and mechanosensation in the kidneys.
  MRC DiMeN Doctoral Training Partnership: Role of RNA modifications in virus infection
  Prof A Whitehouse, Prof S Wilson
Application Deadline: 6 January 2020

Funding Type

PhD Type

As an intermediate molecule in the flow of genetic information, RNA offers a critical junction in the cell to regulate many cellular processes that underpin cell biology, development and tissue function.
  MRC DiMeN Doctoral Training Partnership: Developing microfluidic devices for cellular modelling of inherited eye diseases
  Prof C A Johnson, Prof C Wälti
Application Deadline: 6 January 2020

Funding Type

PhD Type

Inherited retinal dystrophies are a leading cause of blindness and visual loss. Over 20,000 individuals in the UK are registered blind or partially sighted because of these conditions, caused by mutations in over 260 genes.
  MRC DiMeN Doctoral Training Partnership: Nanoinjection: a novel single molecule technique to study alpha-synuclein amyloid toxicity inside neurons
  Dr E W Hewitt, Dr P Actis, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

Project Aims. The aim of this project is to use nanoinjection to perform the quantitative delivery of alpha-synuclein fibrils or oligomers into the cytoplasm of neurons and then determine how many of each is required to induce cellular stress and death.
  MRC DiMeN Doctoral Training Partnership: Understanding zinc-dependent regulation of TRPC5 channels and its role in diabetes
  Dr R.S. Bon, Dr S Muench, Dr P Sukumar
Application Deadline: 6 January 2020

Funding Type

PhD Type

TRPC5 ion channels are emerging drug targets, for example for CNS disorders, renal disease, cancer and cardiovascular disease (Cells 2018, 7, pii.
  Skin protective mechanisms of bioactives from citrus waste
  Research Group: BBSRC White Rose DTP
  Dr C Bosch, Dr C Orfila, Dr J Choo
Application Deadline: 6 January 2020

Funding Type

PhD Type

The skin is the largest organ in our body and a barrier to the external environment. It is subjected to daily stress from biotic and abiotic factors which might affect the skin in its functionality and increase the risk to develop skin related disorders such as inflammatory skin conditions, psoriasis and eczema.
  Bioinspired glycan-nanoparticles as multifunctional mechanistic probes for virus-dendritic cell interactions
  Research Group: BBSRC White Rose DTP
  Prof D Zhou, Prof W B Turnbull, Dr Y Guo
Application Deadline: 6 January 2020

Funding Type

PhD Type

Pathogens such as HIV, mycobacteria can bind specifically to host cell surface lectins via their surface specific glycan patterns to initiate infection.
  Epigenetic temperature sensing in plants
  Research Group: BBSRC White Rose DTP
  Prof B H Davies, Prof A Whitehouse, Dr J Aspden
Application Deadline: 6 January 2020

Funding Type

PhD Type

The changing climate is already having a dramatic effect on the growth and development of the plants that support our entire civilisation.
  Improving the isolation of biologics using molecular modeling and bioinformatics
  Research Group: BBSRC White Rose DTP
  Dr D Tomlinson, Dr E Paci, Prof J Houwing-Duistermaat
Application Deadline: 6 January 2020

Funding Type

PhD Type

with Prof. Jeanine Houwing-Duistermaat. The field of biotechnology has exploded over the past decade with many antibody-based therapeutics dominating the top-ten best selling drugs worldwide.
  Nanoinjection: a single molecule platform for the quantitative and targeted delivery of proteins into cells for functional analysis
  Research Group: BBSRC White Rose DTP
  Dr E W Hewitt, Dr P Actis, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

Interested in amyloid disorders such as Parkinson’s and Huntington’s. Want to work with cutting edge technology in a multidisciplinary team.
  Structural and functional studies on ciliary proteins required for vision
  Research Group: BBSRC White Rose DTP
  Prof C A Johnson, Dr J.J.B. Cockburn, Dr R.F. Thompson
Application Deadline: 6 January 2020

Funding Type

PhD Type

Rod and cone photoreceptor cells in the retina detect light, allowing us to see. When specialised cellular structures in photoreceptors are disrupted, this is a major cause of childhood and adult-onset blindness.
  Uncovering the role of ASPM in mitosis
  Research Group: BBSRC White Rose DTP
  Prof M Peckham, Dr J Bond
Application Deadline: 6 January 2020

Funding Type

PhD Type

ASPM (abnormal spindle-like, microcephaly-associated protein) is essential in determining the plane of division in mitosis. This is important in regulating neuronal development, and enabling humans to have a large brain.
  Uncovering the role of long non-coding RNAs in uterine function for food, fertility, and health
  Research Group: BBSRC White Rose DTP
  Dr N Forde, Dr J Aspden
Application Deadline: 6 January 2020

Funding Type

PhD Type

In all mammalian species studied the majority of pregnancy loss occurs prior to implantation of the embryo into the uterine endometrium.
  Understanding molecular motors through imaging and modelling
  Research Group: BBSRC White Rose DTP
  Dr SA Harris, Prof M Peckham, Dr O.G. Harlen
Application Deadline: 6 January 2020

Funding Type

PhD Type

Dimeric coiled coils are formed by two alpha helices that wrap around each other to bury hydrophobic residues. They are found widely throughout the proteome, and have important mechanical roles in proteins.
  Understanding the role maternal environmental stressors play in endometrial cell signaling: consequences for food, fertility and health.
  Research Group: BBSRC White Rose DTP
  Prof J.E. Ladbury, Dr N Forde
Application Deadline: 6 January 2020

Funding Type

PhD Type

Correct and appropriate function of the uterine endometrium is essential for early pregnancy success in mammalian species and dysregulation of signaling in this tissue leads to pregnancy loss and disease progression.
  How do RNA structures in the Chikungunya virus genome control virus replication in human and mosquito host cells?
  Research Group: BBSRC White Rose DTP
  Dr A.K Tuplin, Prof A Whitehouse
Application Deadline: 6 January 2020

Funding Type

PhD Type

Chikungunya virus is a mosquito-transmitted arbovirus that re-emerged as an epidemic in 2005 around the Indian Ocean, before spreading across Asia, Africa, Europe and the Americas.
  New tools for structural cell biology
  Research Group: BBSRC White Rose DTP
  Prof N A Ranson, Dr R.F. Thompson
Application Deadline: 6 January 2020

Funding Type

PhD Type

Do you like microscopes? This is the project for you!. One of the ultimate aims of structural biology is to understand the structure of macromolecules, and the complexes they make, in their cellular environment.
  Role of m6A reader proteins in virus infection
  Research Group: BBSRC White Rose DTP
  Prof A Whitehouse, Dr A.K Tuplin
Application Deadline: 6 January 2020

Funding Type

PhD Type

RNA is an intermediate molecule in the flow of genetic information from DNA to protein. It is a critical junction for the cell to regulate gene expression, through multiple RNA processing events.
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