Background. Stem cells have an essential role in homeostasis, repair, and regeneration of a tissue or organ. The adult skin is home to largest collection of multipotent stem cells, which are immature cells with unlimited ability to self-renew and capacity to differentiate into different skin cell lineages. Read more
Many viruses infect cells by hijacking cellular trafficking pathways, beginning by using their external spikes to bind specific receptor molecules on the cell surface. Read more
Many viruses infect cells by hijacking cellular trafficking pathways, beginning by using their external spikes to bind specific receptor molecules on the cell surface. Read more
Endothelial cells line blood vessels and are essential for vascular health. They play a critical role in controlling clotting, inflammation and blood pressure. Read more
Primary cilia play a fundamental role in cell signalling, acting as sensory cellular antennae for chemical and biomechanical signals, including morphogen signalling pathways implicated in myofibroblast transition, the key driver of tissue fibrosis. Read more
The PhD Project. Microplastics (MPs) represent an emerging and unappreciated threat to respiratory health. MPs are small plastic particles, that range from 1 µm - 5 mm in size, that can be inhaled and become entrenched within lung tissue. Read more
Maternal diabetes currently affects 21.1 million live births worldwide and the global prevalence is estimated to surge in the next twenty years. Read more
Many plant derived compounds (phytochemicals) have been developed into pharmaceutical drugs. Many other phytochemicals in the modern diet exert potent biological effects on the human body. Read more
Bacteria colonise the surface of human tissues and under certain conditions can cause opportunistic and recurrent infections. Some bacteria, such as Staphylococcus aureus, are able to enter eukaryotic cells and hide away lying dormant, evading immune defences and antibiotic treatment. Read more
Two cancer types that affect opposite ends of the age spectrum, pediatric medulloblastoma and basal cell carcinoma of the skin, are caused by mutations that cause hyperactivation of the Hedgehog signalling pathway. Read more
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