Research Group:
Astbury Centre for Structural Molecular Biology
Antibiotics make possible the treatment and cure of life-threatening bacterial infections and have added over a decade to average human lifespan. Read more
Luotonin A is a natural occurring plant alkaloid bearing polycyclic quinazolinone. It has shown inhibitory effect towards topoisomerase I (TP1), an enzyme responsible for antibiotic and anticancer. Read more
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more
Luminescent molecules that emit visible light with a wave-length of 400–700 nm upon visible light absorption–have been extensively in biomedical research. Read more
The resurgence of covalent drug discovery has yielded FDA-approved drugs in therapeutic areas as diverse as cancer, virology and sickle cell anaemia. Read more
The oxides of a number of materials are very appealing candidates as substitutes for conventional anodes in lithium-ion batteries because of their high theoretical capacity, high electric conductivity low potential of lithium ion intercalation, as well as superior electron mobilities, with one such material, SnO2 being particularly appealing. Read more
White-light emission (WLE) from semiconductor nanostructures is presently a research area of intense interest especially where the primary objective is to replace conventional light sources by environmentally friendly materials in order to minimize energy costs and therefore the global energy consumption for lighting. Read more
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
A project is requested for a student to design a device capable of studying medically targeted nanoparticles (with potential applications in cancer therapy) under both microscopic and fluorescence devices. Read more
Glycans are sugar-based molecules which play an important role in biological processes ranging from cell-cell communication to energy metabolism. Read more
Muscle frailty is a serious condition and highly prevalent in the ageing community. It leads to accidental falls and injuries in aged individuals, and contributes significantly to the poor quality of life. Read more
Muscle frailty is a serious condition and highly prevalent in the ageing community. It leads to accidental falls and injuries in aged individuals, and contributes significantly to the poor quality of life. Read more
Natural products have emerged as a key standard in novel and safe delivery of anticancer bioactive compounds. Apart from their ease of administration and delivery, natural/phytochemicals still face several hurdles, due to their physiochemical and pharmacokinetic properties. Read more
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