V(D)J recombination generates a highly diverse set of immunoglobulin and T cell receptor genes to enable vertebrates to fight a vast range of infections.
The Women’s Ischemic Syndrome Evaluation suggest that 3–4 million women and men with signs/symptoms suggestive of myocardial ischemia have no obstructive coronary artery disease (INOCA).
Metastatic cancer is a major global health burden. Each year, eleven million new cases of cancer are diagnosed worldwide, including 5 million cases in industrialized countries.
Type 2 diabetes (T2D) is an escalating healthcare burden. It inflicts significant physical and emotional distress on patients and their carers, and treatment of T2D and its complications accounts for ~10% of the entire NHS budget.
Heart failure (HF) is characterised by exercise intolerance and high mortality – both of which are significantly exacerbated in patients with concomitant type 2 diabetes (DHF).
This project will build on our recent exciting discovery that a novel chemical tool, the polymer styrene maleic acid (SMA), can ‘biopsy’ human vascular cells, extracting proteins from the membrane without killing the cells.
Research Group:
Astbury Centre for Structural Molecular Biology
Dr E W Hewitt, Prof S E Radford
Applications accepted all year round
The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
Osteoarthritis (OA) and osteoporosis (OP) are the most common age-related skeletal diseases. They seriously affect patient’s quality of life and represent a significant healthcare burden to the UK society.