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Molecular Biology PhD Projects, Programs & Scholarships in Bradford

We have 38 Molecular Biology PhD Projects, Programs & Scholarships in Bradford

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  Health Opportunity for Patient Empowerment in Gestational Diabetes (HOPE-GDM)
  Research Group: Chemistry and Biosciences
  Prof A M Graham, Prof R Qahwaji, Prof A Locke
Applications accepted all year round

Funding Type

PhD Type

Gestational Diabetes is a temporary condition diagnosed at 24-28 weeks gestation, where the body is unable to maintain normal blood glucose levels due to insulin resistance during pregnancy.
  Kinase regulation of HOX transcription factors – a potential target in cancer?
  Research Group: Institute of Cancer Therapeutics
  Prof R Morgan, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

The HOX genes are a family of transcription factors that have a number of important functions in cancer, including cell survival and metastasis.
  Aldehyde dehydrogenase expression and function in cancer stem cells
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr A Mardaryev, Prof A Locke
Applications accepted all year round

Funding Type

PhD Type

Aldehyde dehydrogenases (ALDHs) catalyse the oxidation and detoxification of reactive endogenous and exogenous aldehydes into carboxylic acids via NAD+ coupled reduction.
  Development of transdermal protein liposomal delivery system for the treatment of dermatological diseases
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson
Applications accepted all year round

Funding Type

PhD Type

Biopharmaceuticals have been increasingly used in the treatment of skin diseases. However, due to the poor absorption of peptide and protein through the skin, they are usually delivered through injections.
  Formulation and evaluation of umbilical cord-derived mesenchymal stem cells exosomes and antioxidants, incorporated in nanoliposomes using microfluidics, for the treatment of solid tumours
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson, Dr M Isreb
Applications accepted all year round

Funding Type

PhD Type

This project uses the Cord blood Stem Cells from healthy control and the white blood cells of blood cancer patients to investigate the efficacy and genotoxicity of different compounds in them by using various genetic endpoints.
  Biomarkers of Genotoxic and Reprotoxic Effects after chemical exposure in vitro in human cells
  Research Group: Chemistry and Biosciences
  Prof D Anderson, Dr M Najafzadeh
Applications accepted all year round

Funding Type

PhD Type

In human monitoring procedures, measurements obtained from endpoints to determine genetic damage are sometimes referred to as biomarkers.
  Effect of nanoparticles on cellular conditions in lymphocytes and germ cells in vitro
  Research Group: Chemistry and Biosciences
  Prof D Anderson, Dr M Najafzadeh
Applications accepted all year round

Funding Type

PhD Type

The use of metals such as silver (Ag), gold (Au) and copper (Cu) as nanoparticles (NPs) and other chemicals such as Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (Najafzadeh et al., 2016) in medical and lifestyle applications has exponentially increased in recent years, yet little is still known about their impact on DNA and RNA in somatic as well as in germ cells (Habas et al 2018).
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Application Deadline: 1 June 2020

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  A mechanistic understanding of allosteric regulation of neuronal sodium-activated potassium channels
  Research Group: School of Biomedical Sciences
  Dr J D Lippiat, Dr S Muench, Dr A Kalli
Applications accepted all year round

Funding Type

PhD Type

The sodium-activated potassium channel KNa1.1 (KCNT1, Slack, Slo2.2) is found in neurons and couples sodium influx to excitability.
  Oncogenic reprogramming of immune cells, a novel mechanism of drug-resistance.
  Dr P Laslo
Applications accepted all year round

Funding Type

PhD Type

Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory.
  How protective signals from the gut modify neuronal activity and behaviour, using C. elegans as a model system.
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr P van Oosten-Hawle, Prof N Cohen
Applications accepted all year round

Funding Type

PhD Type

Amyloid protein misfolding leading to loss of neuronal function are fundamental pathogenic mechanisms of numerous age-associated neurodegenerative diseases, including Alzheimer’s (AD).
  Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
  Dr S Papa
Applications accepted all year round

Funding Type

PhD Type

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow.
  Targeting mitochondrial dynamics to prevent Parkinson’s disease
  Prof A Sivaprasadarao, Dr R.S. Bon
Application Deadline: 1 June 2020

Funding Type

PhD Type

A common feature of Parkinson’s disease (PD) is the presence of alpha-synuclein protein aggregates in the brains of affected patients.
  Nanoinjection: a single molecule technique to study amyloid toxicity in neurons
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford, Dr P Actis
Applications accepted all year round

Funding Type

PhD Type

Interested in amyloid disorders such as Parkinson’s and Huntington’s. Want to work with cutting edge technology in a multidisciplinary team.
  Cellular mechanisms of detrimental skeletal muscle remodeling induced by cardiac dysfunction
  Dr T.S. Bowen, Dr D Steele
Application Deadline: 14 June 2020

Funding Type

PhD Type

The loss of skeletal muscle mass and strength is a key impairment in many disease states. This occurs in both limb and respiratory muscles and leads to pulmonary complications and severe disability.
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