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Pharmacology / Toxicology PhD Projects, Programs & Scholarships in Bradford

We have 24 Pharmacology / Toxicology PhD Projects, Programs & Scholarships in Bradford

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  Activity based proteomic probes for profiling CYP2W1 in cancer tissues
  Research Group: Institute of Cancer Therapeutics
  Dr C Sutton, Dr K Pors
Applications accepted all year round

Funding Type

PhD Type

Cytochromes P450 (CYPs) are a superfamily of mixed function oxidases of which CYP1-4 subfamily members are unique in their ability to oxidise drugs.
  Determining brain glycosylation in ageing and Alzheimer’s disease
  Research Group: Pharmacology and Experimental Therapeutics
  Dr R Williamson, Dr C Sutton
Applications accepted all year round

Funding Type

PhD Type

Increasing age is associated with lower levels of cognitive performance; concomitant with this is a decrease in brain glucose metabolism.
  Development of transdermal protein liposomal delivery system for the treatment of dermatological diseases
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson
Applications accepted all year round

Funding Type

PhD Type

Biopharmaceuticals have been increasingly used in the treatment of skin diseases. However, due to the poor absorption of peptide and protein through the skin, they are usually delivered through injections.
  Formulation and evaluation of umbilical cord-derived mesenchymal stem cells exosomes and antioxidants, incorporated in nanoliposomes using microfluidics, for the treatment of solid tumours
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson, Dr M Isreb
Applications accepted all year round

Funding Type

PhD Type

This project uses the Cord blood Stem Cells from healthy control and the white blood cells of blood cancer patients to investigate the efficacy and genotoxicity of different compounds in them by using various genetic endpoints.
  Identifying glucose-dependent mechanisms underlying risk factors for Alzheimer’s disease
  Research Group: Pharmacology and Experimental Therapeutics
  Dr R Williamson, Dr S McLean
Applications accepted all year round

Funding Type

PhD Type

Several risk factors for Alzheimer’s disease including diabetes and midlife obesity are age-dependent and have an obvious metabolic component resulting in impaired glucose metabolism.
  Impact of normal and premature ageing on human macro- and microvasculature
  Research Group: Centre for Skin Sciences
  Dr K Riches-Suman, Dr M J Thornton
Applications accepted all year round

Funding Type

PhD Type

The global population is growing, with the number of births consistently higher than the number of deaths. This is because people are living for longer, due at least in part to improved lifestyle and healthcare provision.
  Aldehyde dehydrogenase expression and function in cancer stem cells
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr A Mardaryev, Prof A Locke
Applications accepted all year round

Funding Type

PhD Type

Aldehyde dehydrogenases (ALDHs) catalyse the oxidation and detoxification of reactive endogenous and exogenous aldehydes into carboxylic acids via NAD+ coupled reduction.
  Development of heterocyclic pharmacophores using diversity-oriented synthesis
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Prof L Patterson
Applications accepted all year round

Funding Type

PhD Type

Diversity-oriented synthesis (DOS) is a modern chemical tool, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression.
  Electrophysiological changes in ion channels in human haploid and diploid (spermatozoa and lymphocytes) after nanoparticle exposure
  Research Group: Chemistry and Biosciences
  Dr L Shang, Dr M H Brinkworth, Prof D Anderson
Applications accepted all year round

Funding Type

PhD Type

Nanomaterial-mediated delivery represents a promising technique for repro- and geno- toxicology with a potential to improve the safety and efficacy of existing methodologies, including experimental gene therapy and sperm-mediated gene transfer.
  Ion channel gating kinetics and structure implication for drug delivery
  Research Group: Chemistry and Biosciences
  Dr L Shang, Dr Z Hughes
Applications accepted all year round

Funding Type

PhD Type

Ion channels are proteins which sit in the membrane of every cell in the body and control the flow of positively charged ions such as sodium and potassium into and out of the cell.
  Therapeutic resolution of pulmonary arterial hypertension (PAH) by natural products
  Research Group: Pharmacology and Experimental Therapeutics
  Dr T Nasim, Prof C Wright
Applications accepted all year round

Funding Type

PhD Type

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death.
  Targeting addiction to a breast cancer metastasis survival pathway by inhibition of RAN GTPase
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Prof M El-Tanani, Dr S Betmouni
Applications accepted all year round

Funding Type

PhD Type

Metastatic cancer is a major global health burden. Each year, eleven million new cases of cancer are diagnosed worldwide, including 5 million cases in industrialized countries.
  Ran GTPase as a potential novel therapeutic target in EMT transdifferentiation and breast cancer stem cell (BCSC) survival during metastatic development
  Research Group: Institute of Cancer Therapeutics
  Prof R Morgan, Prof M El-Tanani, Dr M Isreb, Dr M Najafzadeh
Applications accepted all year round

Funding Type

PhD Type

Breast cancer is the leading cause of cancer death in women worldwide. Accumulating evidence suggests that local disease recurrence and metastatic lesions, the major causes of patient mortality, are due to a subset of aggressive cells termed cancer stem cells (CSCs).
  Re-purposing established drugs for the resolution of pulmonary arterial hypertension (PAH)
  Research Group: Pharmacology and Experimental Therapeutics
  Dr T Nasim
Applications accepted all year round

Funding Type

PhD Type

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder which, if left untreated, leads to heart failure and death.
  Impact of RhoA deregulation on smooth muscle cell phenotypic dysfunction in Type 2 diabetes
  Research Group: Chemistry and Biosciences
  Dr K Riches-Suman
Applications accepted all year round

Funding Type

PhD Type

Type 2 diabetes (T2D) is an escalating healthcare burden. It inflicts significant physical and emotional distress on patients and their carers, and treatment of T2D and its complications accounts for ~10% of the entire NHS budget.
  Pharmaceutical cocrystallisation for improved medicines
  Research Group: Medicines Development and Pharmaceutical Sciences
  Dr V Vangala, Prof A Paradkar
Applications accepted all year round

Funding Type

PhD Type

Active pharmaceutical ingredients (APIs) are frequently delivered to the patients in the solid-state formulation. Yet, therapeutic effectiveness of a dosage form depends on the bioavailability, stability and also on the manufacturability of the dosage form.
  Exploration of 5-fluorouracil resistance mechanisms in colorectal cancer using 5-FU-resistant xenograft models
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Dr C Sutton
Applications accepted all year round

Funding Type

PhD Type

Despite therapeutic advances, colorectal cancer (CRC) still has a 45% mortality rate, and one of the major problems is the development of acquired resistance to treatment with anticancer drugs.
  The effects of androgenetic alopecia development on immune function
  Research Group: Centre for Skin Sciences
  Prof K McElwee, Dr M J Thornton
Applications accepted all year round

Funding Type

PhD Type

Androgen hormones can have significant effects on hair follicles in androgen sensitive regions of the scalp, beard, and other areas of skin.
  Defining active immunoprotection and regulatory T cell promotion in hair follicles
  Research Group: Centre for Skin Sciences
  Prof K McElwee, Dr N Botchkareva
Applications accepted all year round

Funding Type

PhD Type

In the non-scarring inflammatory hair loss disease Alopecia areata (AA) lymphocytes specifically target hair follicles (HFs) and disrupt hair growth.
  Biodegradable composite materials (Bio-PolyMOFs) for applications in targeted delivery of drugs to improve healthcare and reduce antimicrobial resistance in developing countries and worldwide
  Research Group: Chemistry and Biosciences
  Dr S Nayak, Dr A L Kelly, Dr M Katsikogianni
Applications accepted all year round

Funding Type

PhD Type

Growing antimicrobial resistance (AMR) is one of the major global challenges and is linked to the use of unnecessarily high doses of orally administered antibiotics following medical surgery and infections.
  Investigating the mechanism of action of dual antiangiogenic/ antineoplastic drugs using organotypic co-culture of fibroblasts and endothelial cells
  Research Group: Institute of Cancer Therapeutics
  Dr J Elies Gomez, Dr K Pors
Applications accepted all year round

Funding Type

PhD Type

An important feature of many types of cancer is the ability to develop abnormal angiogenesis (blood vessel formation); this allows cancer cells to gain access to nutrients and favours metastasis.
  Therapeutic resolution of Myodysplastic Syndrome (MDS)
  Research Group: Pharmacology and Experimental Therapeutics
  Dr T Nasim, Dr K Pors
Applications accepted all year round

Funding Type

PhD Type

Myelodysplastic syndromes (MDS) are the most common adult myeloid malignancy in the UK and it has been estimated that around 8,000 and 40,000 new cases are diagnosed each year in the UK and USA, respectively.
  Discovery of chemical and biological tools to probe hypoxic solid tumours
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr J Elies Gomez
Applications accepted all year round

Funding Type

PhD Type

A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells. One avenue towards the development of more selective cancer therapies is to exploit the unique physiological properties of solid tumours using prodrug approaches.
  Development and characterisation of synthetic ion channel binding proteins.
  Research Group: School of Biomedical Sciences
  Dr J D Lippiat, Dr D Tomlinson
Applications accepted all year round

Funding Type

PhD Type

We are developing methods to identify novel proteins, Affimers, that recognise extracellular domains of ion channels. These have applications in various aspects of biology, from tools to visualise the location and distribution of ion channels in native tissue, to novel modulators of ion channel function.
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