The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more
Natural products have emerged as a key standard in novel and safe delivery of anticancer bioactive compounds. Apart from their ease of administration and delivery, natural/phytochemicals still face several hurdles, due to their physiochemical and pharmacokinetic properties. Read more
The cancer incidence in UK has risen by 39% over the last decade and advanced disease (metastasis) has poor overall five-year survival rate (5%). Read more
PARP7, an ADP-ribosyltransferase, modulates protein function by adding an ADP-ribose moiety to target proteins. It is involved in many physiological and pathophysiological processes such as neural development, maintenance of stem cells, immunity, xenobiotic metabolism, immunity and cancers. Read more
Pulmonary hypertension (PAH) is debilitating condition characterized by thick and stiff blood vessels that are unable to expand resulting in an increased pressure in the blood vessels supplying the lungs. Read more
Schizophrenia is a psychiatric disorder which severely impairs the individual’s ability to function in society. The most recognised symptoms are delusions and hallucinations, but patients also suffer from memory and attention problems. Read more
Air pollution is a critical global issue with severe consequences for the environment, economy, and human health. 99% of the world’s population lives in areas where air pollution exceeds WHO guidelines, leading to accelerated ageing, increased mortality, and decreased health span [1,2,3]. . Read more
This PhD project is focused on understanding the mechanisms of epidermal growth factor receptor (EGFR) signaling and its role in cellular processes such as proliferation, differentiation, and survival. Read more
Two cancer types that affect opposite ends of the age spectrum, pediatric medulloblastoma and basal cell carcinoma of the skin, are caused by mutations that cause hyperactivation of the Hedgehog signalling pathway. Read more
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