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University of Bristol, Bristol Medical School PhD Projects, Programmes & Scholarships

We have 32 University of Bristol, Bristol Medical School PhD Projects, Programmes & Scholarships

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Bristol Medical School  University of Bristol

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We have 32 University of Bristol, Bristol Medical School PhD Projects, Programmes & Scholarships

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Predicting efficacy and safety of drugs using genetic and population data

A major factor influencing the cost of drugs is the high rate of failure during clinical trials due to inefficacy (failure to have the desired effect) or safety issues (adverse effects). Read more

Realising the potential of data games to keep humans in the loop for the analysis of large and complex data sets in population health sciences

Population health science requires understanding a large and increasing amount of complex data, from complete human genomes and causal networks of the aetiology of disease, to open and unstructured data about community response to rapidly changing public health challenges. Read more

Epigenetic control of transcription factor regulation of adult neurogenesis in the dentate gyrus

In the adult brain, new neurons are continuously generated in the hippocampal dentate gyrus (DG). This neurogenesis process is highly regulated and consists of cell proliferation, neuronal differentiation, neuronal maturation and survival. Read more

Can transcranial ultrasound be used to change the course of neurodegenerative disease?

White matter impairments are a major component of various neurodegenerative diseases, including Alzheimer’s disease(1,2). White matter is composed of neuronal axons and their encasing myelin; a lipid-rich material produced by the oligodendroglia. Read more

Tackling falls and fracture in Parkinson’s

Half of all women, and 20% of men, aged over 50 years will sustain a fracture in their remaining lifetime. However, people with Parkinson’s disease (PwP) are particularly predisposed towards excess fall and fracture risk and subsequent hospital admission. Read more

Vascular endothelial glycocalyx dysfunction as a therapeutic target in sepsis-associated acute kidney injury

Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organs. Read more

Understanding barriers and facilitators of dietary and lifestyle interventions to reduce side effects of treatment and improve outcomes in South Asian men with prostate cancer

Prostate Cancer (PCa) is a leading cause of male mortality, with 336,000 deaths worldwide each year (1). Although most PCa cases are indolent, slow-growing, and tend not to progress, a subset of cases are aggressive and progress to metastases, treatment resistance and death. Read more

The cost of highly hazardous pesticide self-poisoning in India

Over 700,000 people die by suicide annually and 80% of these deaths occurring in low and middle-income countries (LMICs). Suicide by pesticide ingestion is the second most common means of suicide globally - 10-20% of all suicide deaths are by pesticide self-poisoning. Read more

Tissue-engineering constructs suitable for reconstructive cardiac surgery in patients with congenital heart defect

Congenital heart defects (CHD) are the primary cause of infant deaths in Europe and North America. The primary treatment for CHD is surgery but the major problem with surgery for such defects is the lack of living replacement materials with the capacity of growth and regeneration. Read more

Respiratory and anaesthetic characterisation, animal well-being, and refinement of advanced cardiovascular research models in large animal

Supervisors. Vito Domenico Bruno (primary supervisor), Raimondo Ascione. Background. Millions of patients globally are still suffering with severe cardiovascular disease leading to death or debilitating complications such as myocardial infarction, heart failure, stroke, and limb amputation (1-2). Read more

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