University of Bristol’s Cabot Institute for the Environment and Elizabeth Blackwell Institute for Health Research are looking to recruit a PhD student in the area of Climate Change and Health. Read more
A major factor influencing the cost of drugs is the high rate of failure during clinical trials due to inefficacy (failure to have the desired effect) or safety issues (adverse effects). Read more
Our ability to remember ‘where I put my car keys today’ as opposed to ‘where I put them yesterday’ depends on a computational process known as pattern separation. Read more
Population health science requires understanding a large and increasing amount of complex data, from complete human genomes and causal networks of the aetiology of disease, to open and unstructured data about community response to rapidly changing public health challenges. Read more
International efforts to eliminate HIV/AIDS by 2030 are failing high-risk populations, particularly people who inject drugs (PWID), who frequently have high HIV prevalence[1]. Read more
In the adult brain, new neurons are continuously generated in the hippocampal dentate gyrus (DG). This neurogenesis process is highly regulated and consists of cell proliferation, neuronal differentiation, neuronal maturation and survival. Read more
White matter impairments are a major component of various neurodegenerative diseases, including Alzheimer’s disease(1,2). White matter is composed of neuronal axons and their encasing myelin; a lipid-rich material produced by the oligodendroglia. Read more
Half of all women, and 20% of men, aged over 50 years will sustain a fracture in their remaining lifetime. However, people with Parkinson’s disease (PwP) are particularly predisposed towards excess fall and fracture risk and subsequent hospital admission. Read more
Prostate cancer is the UK’s commonest male cancer and represents a significant public health challenge. The UK National Screening Committee currently does not recommend prostate cancer screening1. Read more
Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organs. Read more
The 2022 Avian Influenza outbreak in the UK is largest on record and the first time farm-to-farm transmission and animal-to-human transmission has been identified[1]. Read more
Prostate Cancer (PCa) is a leading cause of male mortality, with 336,000 deaths worldwide each year (1). Although most PCa cases are indolent, slow-growing, and tend not to progress, a subset of cases are aggressive and progress to metastases, treatment resistance and death. Read more
Over 700,000 people die by suicide annually and 80% of these deaths occurring in low and middle-income countries (LMICs). Suicide by pesticide ingestion is the second most common means of suicide globally - 10-20% of all suicide deaths are by pesticide self-poisoning. Read more
Congenital heart defects (CHD) are the primary cause of infant deaths in Europe and North America. The primary treatment for CHD is surgery but the major problem with surgery for such defects is the lack of living replacement materials with the capacity of growth and regeneration. Read more
Supervisors. Vito Domenico Bruno (primary supervisor), Raimondo Ascione. Background. Millions of patients globally are still suffering with severe cardiovascular disease leading to death or debilitating complications such as myocardial infarction, heart failure, stroke, and limb amputation (1-2). Read more
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