We have 29 Genetics PhD Projects, Programmes & Scholarships in Bristol

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Genetics PhD Projects, Programmes & Scholarships in Bristol

We have 29 Genetics PhD Projects, Programmes & Scholarships in Bristol

University of Bristol

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Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

University of Bristol Bristol Medical School
Project Background. Genome wide association studies (GWAS) have discovered many genetic associations with health outcomes. However, most GWAS signals reside in non-coding regions and it is likely that GWAS variants confer their effects through a regulatory mechanism. Read more
 Supervisors: Dr J Min, Dr E Hannon, Prof J MIll, Dr GL Leyden
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

University of Bristol Bristol Medical School
Genome wide association studies (GWAS) have discovered many genetic associations for traits and diseases. However, most GWAS signals reside in non-coding regions (outside genes), and it is likely that GWAS variants confer their effects through modulating regulatory mechanism. Read more
 Supervisor: Dr J Min
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Understanding psychiatric outcomes in children born with cleft lip and/or palate using genetics

University of Bristol Bristol Medical School
Rationale. Cleft of the lip and/or palate is a common birth defect worldwide and occurs at a rate of one in 650 live births in the UK. Read more
 Supervisors: Dr E Stergiakouli, Dr S Lewis, Prof M J Owen, Dr M van den Bree
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The genetics of human scarring – cross-cutting approaches to the understanding of human wound repair.

University of Bristol Bristol Medical School
Rationale. Repair of adult tissues involves a complex interplay of several key cell lineages and inevitably leads to formation of a fibrotic collagenous scar. Read more
 Supervisors: Prof N Timpson, Prof P Martin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Harnessing genetics of DNA methylation to elucidate molecular mechanisms underlying human phenotypes.

University of Bristol Bristol Medical School
Rationale. GWAS studies have discovered many genetic associations for traits and diseases, but it has been difficult to elucidate the functional consequences of these variants. Read more
 Supervisors: Dr J Min, Prof C Relton, Prof J MIll, Dr E Hannon, Dr G Hemani, Prof T Gaunt, Dr B Heijmans, Dr J Bell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Younger, happier and more productive plants: using developmental genetics to improve herb yields and quality

University of Bristol School of Biological Sciences
If you’ve ever grown coriander at home you’ll have noticed that once the plant flowers it no longer produces the leaves used for seasoning. Read more
 Supervisor: Dr J Fouracre
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The genetic map of human molecular phenotypes

University of Bristol Bristol Medical School
Rationale. Genome wide associations studies (GWASs) have discovered many genetic associations with a large range of human traits, but the functional consequences of GWAS signals often remain elusive, as most GWAS signals reside in non-coding genomic regions. Read more
 Supervisors: Dr J Min, Dr G Hemani, Dr JH Hawe
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Identifying causal pathways to disease using DNA methylation predicted blood traits.

University of Bristol Bristol Medical School
Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more
 Supervisors: Dr J Min, Dr E Hannon, Prof J MIll
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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An investigation of the causal relationship and genetic overlap between sleep traits and physical and mental health using Mendelian randomization

University of Bristol Bristol Medical School
Rationale. Sleep has long been known to play a role in physical and mental wellbeing and sleep disruption has been observed to co-occur with a number of health conditions including. Read more
 Supervisors: Dr S Lewis, Dr MR Renteria, Dr HJ Jones
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Understanding and curing genetic kidney disease

University of Bristol Bristol Medical School
Steroid Resistant Nephrotic syndrome (SRNS) is a rare kidney condition which causes excess fluid to be retained in the body which causes swelling (oedema). Read more
 Supervisors: Prof M Saleem, Prof G Welsh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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A study of the natural history of joint hypermobility using a population-based birth cohort

University of Bristol Bristol Medical School
People with generalised joint hypermobility (GJH) are described as being ‘double-jointed’ because their joints are more flexible and bendy than other people’s. Read more
 Supervisors: Dr E Clark, Prof A Judge, Prof S Palmer
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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The use of life course epidemiology to support the experimental characterisation of genetic variation

University of Bristol Bristol Medical School
Project Background. There has been a rapid expansion in the generation of genetic sequence data over the last decade. Understanding the potential relevance of genetic mutations to human health remains challenging. Read more
 Supervisors: Prof N Timpson, Dr L Corbin, Dr BL Lam
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Prospectively mapping the development of liver disease amongst young adults. Who is developing it early and why?

University of Bristol Bristol Medical School
Rationale. Historically, cirrhosis (irreversible liver scarring), often due to alcohol-related liver disease (ARLD) and non-alcoholic fatty liver disease (NAFLD), presents in the 5th and 6th decade. Read more
 Supervisors: Dr KA Abeysekera, Prof M Hickman, Prof N Timpson
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Prenatal and pre-conception effects on neurodevelopmental disorders.

University of Bristol Bristol Medical School
Rationale. There is growing concern that paternal exposures before conception have been greatly neglected. Studying how these impact on future generations’ health could open new avenues for prevention-prospective fathers are not generally advised to change their behaviour. Read more
 Supervisors: Dr L Zuccolo, Dr G Sharp, Dr D Caramaschi, Prof A Thapar
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Mendelian Randomisation for mediation analysis with multiple mediators: theory and applications

University of Bristol Bristol Medical School
Rationale. Many of an individual’s traits are observationally associated with their health outcomes. Understanding the relationships between these factors is critical to effective public health intervention. Read more
 Supervisors: Dr E Sanderson, Dr R Daniel, Dr L Howe
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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