Human Genetics PhD Projects, Programmes & Scholarships in Bristol

We have 25 Human Genetics PhD Projects, Programmes & Scholarships in Bristol

The genetics of human scarring – cross-cutting approaches to the understanding of human wound repair.

University of Bristol Bristol Medical School

Rationale. Repair of adult tissues involves a complex interplay of several key cell lineages and inevitably leads to formation of a fibrotic collagenous scar. Read more

Supervisors: Prof N Timpson, Prof P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Harnessing genetics of DNA methylation to elucidate molecular mechanisms underlying human phenotypes.

University of Bristol Bristol Medical School

Rationale. GWAS studies have discovered many genetic associations for traits and diseases, but it has been difficult to elucidate the functional consequences of these variants. Read more

Supervisors: Dr J Min, Prof C Relton, Prof J MIll, Dr E Hannon, Dr G Hemani, Prof T Gaunt, Dr B Heijmans, Dr J Bell

Year round applications PhD Research Project Self-Funded PhD Students Only

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The genetic map of human molecular phenotypes

University of Bristol Bristol Medical School

Rationale. Genome wide associations studies (GWASs) have discovered many genetic associations with a large range of human traits, but the functional consequences of GWAS signals often remain elusive, as most GWAS signals reside in non-coding genomic regions. Read more

Supervisors: Dr J Min, Dr G Hemani, Dr JH Hawe

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding psychiatric outcomes in children born with cleft lip and/or palate using genetics

University of Bristol Bristol Medical School

Rationale. Cleft of the lip and/or palate is a common birth defect worldwide and occurs at a rate of one in 650 live births in the UK. Read more

Supervisors: Dr E Stergiakouli, Dr S Lewis, Prof M J Owen, Prof MVDB van den Bree

Year round applications PhD Research Project Self-Funded PhD Students Only

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The use of life course epidemiology to support the experimental characterisation of genetic variation

University of Bristol Bristol Medical School

Project Background. There has been a rapid expansion in the generation of genetic sequence data over the last decade. Understanding the potential relevance of genetic mutations to human health remains challenging. Read more

Supervisors: Prof N Timpson, Dr L Corbin, Dr BL Lam

Year round applications PhD Research Project Self-Funded PhD Students Only

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Prospectively mapping the development of liver disease amongst young adults. Who is developing it early and why?

University of Bristol Bristol Medical School

Rationale. Historically, cirrhosis (irreversible liver scarring), often due to alcohol-related liver disease (ARLD) and non-alcoholic fatty liver disease (NAFLD), presents in the 5th and 6th decade. Read more

Supervisors: Dr KA Abeysekera, Prof M Hickman, Prof N Timpson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Prenatal and pre-conception effects on neurodevelopmental disorders.

University of Bristol Bristol Medical School

Rationale. There is growing concern that paternal exposures before conception have been greatly neglected. Studying how these impact on future generations’ health could open new avenues for prevention-prospective fathers are not generally advised to change their behaviour. Read more

Supervisors: Dr L Zuccolo, Dr G Sharp, Dr D Caramaschi, Prof A Thapar

Year round applications PhD Research Project Self-Funded PhD Students Only

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Mendelian Randomisation for mediation analysis with multiple mediators: theory and applications

University of Bristol Bristol Medical School

Rationale. Many of an individual’s traits are observationally associated with their health outcomes. Understanding the relationships between these factors is critical to effective public health intervention. Read more

Supervisors: Dr E Sanderson, Dr R Daniel, Dr L Howe

Year round applications PhD Research Project Self-Funded PhD Students Only

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Linking multivariable Mendelian randomization with lifecourse epidemiology: developing the methodology and application to a contemporary exemplar

University of Bristol Bristol Medical School

Rationale. Mendelian randomization (MR) uses genetic variants as instrumental variables to estimate the causal effect of an exposure on an outcome, free from bias due to unobserved confounding. Read more

Supervisors: Dr E Sanderson, Prof K Tilling, Prof G Davey-Smith

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the genetic architecture of orofacial cleft: A genome-wide association study using trio data and an investigation of parent of origin and mother-children interaction effects.

University of Bristol Bristol Medical School

Rationale. Orofacial clefts (OFCs) are the most prevalent craniofacial congenital disabilities globally, occurring at a frequency of 1 out of 700 newborns. Read more

Supervisors: Dr S Lewis, Dr E Stergiakouli, Prof H Cordell

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating causal effects of neurodevelopmental and mental health problems in childhood on adult physical health

University of Bristol Bristol Medical School

Rationale. Neurodevelopmental and mental health problems in childhood have been linked to adverse physical health outcomes in both childhood and adult life. Read more

Supervisors: Dr E Stergiakouli, Dr L Howe, Dr RB Blakey, Ms CD Dardani

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying metabolic drivers of cancer development

University of Bristol Bristol Medical School

Rationale. Growing evidence suggests that cell extrinsic factors are key in modulating tumor progression. Metabolites are small molecules that act as sources of fuel and building blocks essential for cells and tissues when present at normal levels. Read more

Supervisors: Dr E Vincent, Dr CB Bull, Prof N Timpson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying DNA methylation signatures of prostate cancer progression and mortality among patients with clinically confirmed, localised disease at baseline in a large prospective clinical trial

University of Bristol Bristol Medical School

Rationale. Prostate Cancer (PCa) is a leading cause of male mortality, with 336,000 deaths worldwide each year (1). Although most PCa cases are indolent, slow-growing, and tend not to progress, a subset of PCa cases are more aggressive and will progress to metastases, treatment resistance and death. Read more

Supervisors: Dr P Yousefi, Prof R Martin, Dr M Suderman, Dr A Lane, Dr SM Merriel

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying causal risk factors for disease progression

University of Bristol Bristol Medical School

Rationale. Typical epidemiological studies aim to identify causal risk factors for onset of disease by comparing diseased cases with disease free controls. Read more

Supervisors: Dr L Paternoster, Prof G Davey-Smith, Dr A Hartley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identifying causal pathways to disease using DNA methylation predicted blood traits.

University of Bristol Bristol Medical School

Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more

Supervisors: Dr J Min, Dr E Hannon, Prof J MIll

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 25 Human Genetics PhD Projects, Programmes & Scholarships in Bristol

Human Genetics PhD Projects, Programmes & Scholarships in Bristol

We have 25 Human Genetics PhD Projects, Programmes & Scholarships in Bristol

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