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We have 68 Medicine PhD Projects, Programmes & Scholarships in Bristol

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Medicine

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Bristol  United Kingdom

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Medicine PhD Projects, Programmes & Scholarships in Bristol

We have 68 Medicine PhD Projects, Programmes & Scholarships in Bristol

Understanding the role of adiponectin in kidney disease development at a population level

Reduced circulating adiponectin levels are associated with poor outcome in patients with diabetic kidney disease (DKD) (1). Adiponectin has been shown to be protective against the development of DKD in Type 2 diabetic models (2, 3, 4). Read more

Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease

Genome wide association studies (GWAS) have discovered many genetic associations for traits and diseases. However, most GWAS signals reside in non-coding regions (outside genes), and it is likely that GWAS variants confer their effects through modulating regulatory mechanism. Read more

Endothelial glycocalyx damage as a therapeutic target in sepsis-associated Acute Kidney Injury

Sepsis is the leading cause of acute kidney injury (sAKI), associated with high morbidity and mortality.1,2 Unfortunately, there is no treatment for sAKI, current therapies are nonspecific and supportive of the vital organ systems in the hope the kidney will recover. Read more

Creating patient-specific retinal organoids from human induced pluripotent stem cells for in vitro simulation of uveitis

Uveitis, although uncommon, is a notable cause of visual impairment and blindness. Uveitis encompasses a range of conditions driven by both innate autoinflammatory and adaptive autoimmune CD4 T-cell responses. Read more

What outcomes are important to patients with osteoarthritis? Development of a core outcome set

Osteoarthritis is the most common musculoskeletal condition worldwide and is the leading cause of disability in the UK. In our recent study to identify research priorities in osteoarthritis, the highest priority question to patients was “What outcomes are important to patients?”[1]. Read more

Epilepsy and the ageing brain

Our ability to remember ‘where I put my car keys today’ instead of ‘where I put them yesterday’ depends on a computational process called pattern separation. Read more

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