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Molecular Biology PhD Projects, Programs & Scholarships in Bristol

We have 31 Molecular Biology PhD Projects, Programs & Scholarships in Bristol

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Bristol  United Kingdom

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We have 31 Molecular Biology PhD Projects, Programs & Scholarships in Bristol

Mechanisms of molecular recognition by the prokaryotic argonautes

The discovery of CRISPR-Cas has been one of the most important scientific breakthroughs of the 21st century. The programmable sequence-specific interactions between Cas enzymes, such as Cas9, and DNA have been harnessed to produce revolutionary tools for gene editing and diagnostics. Read more

Simulation-led investigation and engineering of enzymes involved in abyssomicin antibiotic biosynthesis

Enzymes are remarkable biocatalysts that allow rapid, selective and efficient catalysis under mild conditions. Biotechnology exploits the outstanding rate-enhancing properties of these natural biocatalysts to manufacture high added-value products. Read more

Exploring the similarities between neointimal formation after vascular injury and tumour growth

Rationale. Vascular smooth muscle cell (VSMC) proliferation leads to intimal thickening, which causes reoccurrence of symptoms (restenosis) in 30-50% of coronary artery disease patients receiving saphenous vein grafts and individual receiving stent implantation. Read more

Alpha-synuclein and microRNA function in human dopamine neurons

Rationale. Parkinson’s is a neurodegenerative disorder that is characterised by the loss of dopamine neurons in the substantia nigra, leading to impairment of the motor system and other non-motor symptoms such as loss of smell, cognitive and sleep disorders. Read more

SELF-FUNDING MSc BY RESEARCH PROJECT: Underlying mechanism of thrombogenesis in patients with severe coronavirus disease 19 (COVID-19)

Severe coronavirus disease 19 (COVID-19) is a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Patients with COVID-19 are at significantly increased risk of thrombosis, which can be a challenge to manage and is associated with elevated mortality and morbidity. Read more

Effects of transcription on genome stability

Transcription-coupled DNA repair (TCR) pathways prioritise the repair of certain lesions in "active" genes. These pathways help maintain genome integrity throughout the lifetime of multi-cellular organisms, and thus help prevent the occurrence of mutation that might cause cancer or other disorders. Read more

Structural analysis of the inter-membrane bacterial secretosome

Protein secretion is essential for life. Bacteria secrete proteins for a wide range of membrane and extracellular activities, including envelope biogenesis, pathogenicity and degradation of antibiotics. Read more

Assessing neuroinflammation and vascular dementia in association with atherosclerosis and aneurysm risk

Rationale. There is now substantial data demonstrating an association between high morbidity and mortality cardiovascular diseases (such as atherosclerosis and aortic aneurysms) with the onset of neurodegenerative diseases, particularly vascular dementia. Read more

Discovery and validation of clinically useful biomarkers for osteoarthritis

Project Description. Osteoarthritis (OA) is one of the most common chronic diseases affecting the adult population. Currently, definitive diagnosis of OA is usually made using plain x-rays at relatively advanced stages of the disease when there is irreparable damage to the joint(s). Read more

Does ultrasound-mediated neuromodulation restore cellular function in Alzheimer’s disease?

Rationale. A key feature of Alzheimer’s disease – the leading form of dementia - is diminished neural activity in various brain regions, including those important for memory function such as the hippocampus (Herholz et al., 2007; O’Brien et al., 2010). Read more

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