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We have 9 Molecular Genetics PhD Projects, Programmes & Scholarships in Bristol
Molecular Genetics PhD Projects, Programmes & Scholarships in Bristol
We have 9 Molecular Genetics PhD Projects, Programmes & Scholarships in Bristol
The genetic map of human molecular phenotypes
Rationale. Genome wide associations studies (GWASs) have discovered many genetic associations with a large range of human traits, but the functional consequences of GWAS signals often remain elusive, as most GWAS signals reside in non-coding genomic regions. Read more
Harnessing genetics of DNA methylation to elucidate molecular mechanisms underlying human phenotypes.
Rationale. GWAS studies have discovered many genetic associations for traits and diseases, but it has been difficult to elucidate the functional consequences of these variants. Read more
Younger, happier and more productive plants: using developmental genetics to improve herb yields and quality
If you’ve ever grown coriander at home you’ll have noticed that once the plant flowers it no longer produces the leaves used for seasoning. Read more
Understanding psychiatric outcomes in children born with cleft lip and/or palate using genetics
Rationale. Cleft of the lip and/or palate is a common birth defect worldwide and occurs at a rate of one in 650 live births in the UK. Read more
The use of life course epidemiology to support the experimental characterisation of genetic variation
Project Background. There has been a rapid expansion in the generation of genetic sequence data over the last decade. Understanding the potential relevance of genetic mutations to human health remains challenging. Read more
Identifying causal pathways to disease using DNA methylation predicted blood traits.
Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more
Harnessing the genetics of DNA methylation to understand context-specific gene regulation in disease
Project Background. Genome wide association studies (GWAS) have discovered many genetic associations with health outcomes. However, most GWAS signals reside in non-coding regions and it is likely that GWAS variants confer their effects through a regulatory mechanism. Read more
Evaluating the role of circulating proteins in cancer risk and progression using genetic and observational approaches
Rationale. Circulating proteins play fundamental roles in biology and disease aetiology, including development of cancer, and are the direct targets of many drugs (1). Read more
Self-funded PhD- Understanding the molecular mechanism of a bacterial genome defence system and its synergy with CRISPR-Cas
Prokaryotes have evolved over billions of years alongside their viruses, the bacteriophages, or “phages”. To prevent viral infection, prokaryotes have evolved rudimentary immune mechanisms, the most widespread and well-studied of which are the Restriction-Modification and the CRISPR-Cas enzymes. Read more
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