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We have 22 Pathology PhD Projects, Programmes & Scholarships in Bristol
Pathology PhD Projects, Programmes & Scholarships in Bristol
We have 22 Pathology PhD Projects, Programmes & Scholarships in Bristol
Investigating associations between the brain renin angiotensin system and Traumatic Brain Injury
In the last decade the involvement of the brain Renin Angiotensin System (RAS) in neurodegenerative disease, particularly Alzheimer’s disease (AD) has come to the fore. Read more
Studies of brain renin angiotensin system changes in Parkinson’s disease to find new treatments
Parkinson’s disease (PD) is the second most common forms of neurodegenerative disease and affects people from the ages of 50years and above. Read more
How can we use transcranial ultrasound brain stimulation to restore cellular function in Alzheimer’s disease?
A key feature of Alzheimer’s disease – the leading form of dementia - is diminished neural activity in various brain regions, including those important for memory function such as the hippocampus (Herholz et al., 2007; O’Brien et al., 2010). Read more
Does the brain renin angiotensin system influence the occurrence of depression in Alzheimer’s disease?
In the last decade the involvement of imbalance in counterbalancing arms of the brain Renin Angiotensin System (RAS) has been found to be a significant factor in Alzheimer’s disease (AD). Read more
Exploring the similarities between neointimal formation after vascular injury and tumour growth
Vascular smooth muscle cell (VSMC) proliferation leads to intimal thickening, which causes reoccurrence of symptoms (restenosis) in 30-50% of coronary artery disease patients receiving saphenous vein grafts and individual receiving stent implantation. Read more
Targeting acute inflammation to reduce coronary artery vein graft failure using bioengineering
The long saphenous vein (LSV) is the most commonly used conduit in cardiac surgery to treat patients with coronary artery disease; however, its use is complicated by high failure rates due to the development of vascular inflammation, intimal hyperplasia (IH) and accelerated atherosclerosis. Read more
The effect of age on arterial remodelling: relevance to atherosclerotic plaque progression and aneurysm formation
Atherosclerosis is an inflammatory vascular disease involving plaques composed of lipid-dense cores filled with activated, apoptotic and necrotic inflammatory and vascular cells coated with a fibrous cap. Read more
Evaluation of novel therapies for human coronary artery bypass graft disease
Vascular smooth muscle cell (VSMC) proliferation leads to intimal thickening, which causes reoccurrence of symptoms (restenosis) in 30-50% of coronary artery disease patients receiving saphenous vein grafts [1-2]. Read more
Prospectively mapping the development of liver disease amongst young adults. Who is developing it early and why?
Rationale. Historically, cirrhosis (irreversible liver scarring), often due to alcohol-related liver disease (ARLD) and non-alcoholic fatty liver disease (NAFLD), presents in the 5th and 6th decade. Read more
Mendelian Randomisation for mediation analysis with multiple mediators: theory and applications
Rationale. Many of an individual’s traits are observationally associated with their health outcomes. Understanding the relationships between these factors is critical to effective public health intervention. Read more
Linking multivariable Mendelian randomization with lifecourse epidemiology: developing the methodology and application to a contemporary exemplar
Rationale. Mendelian randomization (MR) uses genetic variants as instrumental variables to estimate the causal effect of an exposure on an outcome, free from bias due to unobserved confounding. Read more
Integration of transactional and Ecological Momentary Assessment data for cancer risk factor prediction
Rationale. Shopping history records, collected via purchases tracked on loyalty cards, can provide a new perspective on lifestyle choices and behaviours and how these relate to health outcomes such as cancer. Read more
Identifying DNA methylation signatures of prostate cancer progression and mortality among patients with clinically confirmed, localised disease at baseline in a large prospective clinical trial
Rationale. Prostate Cancer (PCa) is a leading cause of male mortality, with 336,000 deaths worldwide each year (1). Although most PCa cases are indolent, slow-growing, and tend not to progress, a subset of PCa cases are more aggressive and will progress to metastases, treatment resistance and death. Read more
Identifying causal risk factors for disease progression
Rationale. Typical epidemiological studies aim to identify causal risk factors for onset of disease by comparing diseased cases with disease free controls. Read more
Identifying causal risk factors and outcomes of atopic dermatitis
Rationale. Several traits such as cardiovascular disease[1] and mental health disorders[2] have been reported to be observationally associated with atopic dermatitis (AD). Read more
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