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We have 13 University of Cambridge, Cambridge Stem Cell Institute PhD Projects, Programmes & Scholarships
University of Cambridge, Cambridge Stem Cell Institute PhD Projects, Programmes & Scholarships
We have 13 University of Cambridge, Cambridge Stem Cell Institute PhD Projects, Programmes & Scholarships
Using human organoids to unravel epigenetic mechanisms in health and Inflammatory Bowel Diseases
Project Overview. The intestinal epithelium provides a critical barrier that contributes towards the establishment of a finely tuned homeostasis in the human gut. Read more
Mechanisms regulating blood stem cell self-renewal and differentiation
Project Overview. The Wilkinson research group focuses on the biology and translational applications of blood-forming haematopoietic stem cells (HSCs). Read more
Cancer-associated sensitisation mechanisms to selective RNA methyltransferase inhibition
Project Overview. Epitranscriptomics, the modulation of RNA function via its chemical modification, has emerged as a pervasive new mechanism of gene regulation. Read more
Multiomics to decipher T cell development in the thymus
Project Overview. Ongoing projects in the Teichmann team are generating scRNA-seq and chromatin accessibility profiles of thymic cells using the 10X multiome kit, combined with multiplex protein staining. Read more
Unravelling The Parallels Between Regeneration & Tumorigenesis
Project Overview. Some organisms, such as salamanders, retain a remarkable capacity for regeneration in various organs, which occurs through the process of epimorphic regeneration. Read more
Patient outcomes and new therapies in aortic aneurysm using iPSC ‘disease-in-a-dish’ models
Project Overview. We have pioneered the use of induced pluripotent stem cells from patients with genetically mediated aortic aneurysms (such as Marfan and Loeys-Dietz syndromes) to set up ‘disease-in-a-dish’ in vitro models (PMIDs. Read more
Understanding the stress biology underlying human haematopoietic stem cell adaptation to clinically-relevant ex vivo culture
Project Overview. Haematopoietic Stem Cell (HSC) Gene Therapy (GT) is the only curative option for many monogenic inherited disorders. Read more
The tipping point: what drives the progression of breast precancer cells
Project Overview. Understanding the molecular and cellular mechanisms of how epithelial tissues maintain a homeostatic state throughout the lifespan of mammals is a major challenge for developmental and stem cell biology. Read more
Rethinking the human proteome: bioactive microproteins in non-Hodgkin lymphoma
Project Overview. The human genome is believed to contain approximately 20,000 protein-coding genes. These were originally annotated based on criteria for predicting synthesis of stable proteins, including an arbitrary size threshold of 100 amino acids. Read more
Studying the impact of parasitic worm infections on intestinal stem cell fate and differentiation
Project Overview. Whipworms infect hundreds of millions of people and cause trichuriasis, a major neglected disease. These large metazoan parasites inhabit a multi-intracellular niche within their host gut lining, where they can remain for years. Read more
Functional interrogation of human gastrulation in bioprinted embryo models
Project Overview. Functional interrogation of human gastrulation in bioprinted embryo models. How do complex body patterns emerge in the early embryo? The first signs of the human body axis can be traced back to the second week of gestation. Read more
Mapping a blueprint of ageing across tissue scales
Project Overview. Despite decades of intense research, modern medicine still faces a critically unresolved question. Read more
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