Background. Hydrogen Induced Cracking (HIC) / Stress Oriented Hydrogen Induced Cracking (SOHIC) is the process of hydrogen forming metals becoming brittle as a result of the diffusion mechanisms of hydrogen into the microstructure of steel structures.
Herpesviruses are highly successful pathogens that cause disease in animals and humans. In particular, the alphaherpesvirus subfamily includes significant veterinary pathogens many of which are designated notifiable diseases by the Department for Environment, Food and Rural Affairs.
Understanding host responses to pathogen infection is critical for guiding the development of intervention strategies. Changes in gene expression are commonly observed upon infection, as exemplified by numerous transcriptomic studies.
Vaccinia virus is the live vaccine that was used to eradicate smallpox. After smallpox eradication, VACV has been exploited to build vaccines against other diseases and continues to be studied to better understand virus interactions with the host cell and the immune system.