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Biochemistry PhD Projects, Programs & Scholarships in Cambridge

We have 20 Biochemistry PhD Projects, Programs & Scholarships in Cambridge

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Discipline

Chemical Sciences

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Location

Cambridge  United Kingdom

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We have 20 Biochemistry PhD Projects, Programs & Scholarships in Cambridge

NMR spectroscopy in structural biology

1.) NMR method development. NMR is a versatile technique that is used to study structure, dynamics and various functional aspects of proteins and their complexes with their interaction partners. Read more

Regulation of virulence and biofilm formation by quorum sensing and the "stress alarmone" ppGpp in gram-negative pathogenic bacteria.

We are investigating the complex interplay between cell-cell signalling (quorum sensing), microbial lifestyle (i.e., free-living planktonic cultures vs sessile biofilm communities), growth phase and virulence in gram-negative bacteria. Read more

Structure, regulation and dynamics of small G proteins and their interactions with membranes and effector proteins

Our lab are interested in cell signalling via small G proteins of the Ras superfamily. We use a range of biochemical, biophysical and structural approaches to understand these fascinating proteins, which are involved in multiple cellular processes and are often deregulated in diseases such as cancer. Read more

Structural and functional analysis of DNA double strand break repair.

Eukaryotic cells have evolved complex molecular systems in order to detect and repair double-strand breaks (DSBs) of the DNA helix, which can arise from exposure to genotoxic agents or during normal nucleic acid metabolism. Read more

Genome-wide translational responses to stress

We are interested in gene regulation in responses to stress, using both simple model organisms, human and plant pathogens. Cells respond to stress conditions by launching complex programs of gene expression, both transcriptional and posttranscriptional, and which are often closely linked with each other. Read more

Organisational and regulatory roles of disordered proteins

Proteins are often depicted as visually compelling three-dimensional arrangements of alpha helices and beta sheets that recognise their biological partners via structurally complementary surfaces, like the pieces of a jigsaw puzzle. Read more

Exploring the Molecular Mechanism of Novel Mitochondrial Toxic Drugs identified through a Machine Learning Approach

In drug development, mitochondrial inhibition is an important ‘OFF-target’ mechanism of drug-induced toxicity in the clinic, contributing to drug attrition in clinical trials as well as drug withdrawal following approval due to severe adverse events (Will & Dykens, 2014). Read more

How do evolutionary changes in innate immune genes influence the carriage of zoonotic pathogens

Zoonotic pathogens, such as COVID-19, reside in animal hosts before jumping species to infect humans. How diversity in host immune genes across species impact upon pathogen carriage are poorly understood. Read more

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