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Biological & Medical Sciences PhD Projects, Programs & Scholarships in Cambridge
We have 190 Biological & Medical Sciences PhD Projects, Programs & Scholarships in Cambridge
We have 190 Biological & Medical Sciences PhD Projects, Programs & Scholarships in Cambridge
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Nanometer scale mapping as a tool to analyse adverse outcome pathways
Super-resolution fluorescence microscopy has revolutionized the understanding of cellular organization by allowing quantitative analysis of protein assemblies architecture, in situ, at the nanoscale (Sydor et al. Read more
Characterization of novel airway in vitro models for discovery toxicology
The cellular and molecular mechanisms of human lung development are only recently beginning to emerge. This knowledge gap has been mainly determined by the paucity of ex vivo material for research studies and the lack of adequate animal models recapitulating human lung development (Nikolic et al. Read more
EPSRC Centre for Doctoral Training in Sensor Technologies for a Healthy and Sustainable Future (Sensor CDT)
The EPSRC Centre for Doctoral Training in Sensor Technologies for a Healthy and Sustainable Future (Sensor CDT), at the University of Cambridge, is looking for aspirational, enthusiastic and open-minded students to join its vibrant environment. Read more
Characterisation of 3D liver models for discovery toxicology and pathology
Human cells endure a lifetime of exposure to endogenous and exogenous toxicants. For example, the gastrointestinal tract, including the liver, is exposed to a vast array of dietary metabolites, drugs, and other xenobiotics, as well as commensal and pathogenic organisms. Read more
Exploring the Molecular Architecture of FADD:Caspase-8 Signalling Platforms and how this determines cell fate
Following exposure to drugs or environmental agents, several large multi-protein signalling platforms play a key role in determining cell death or survival. Caspase-8, a key regulator of cell fate, is recruited/activated within these complexes; for example, the Death-Inducing Signalling Complex (DISC), Necrosome and Ripoptosome. Read more
Exploring the Molecular Mechanism of Novel Mitochondrial Neurotoxins identified through a Machine Learning Approach
Mitochondrial inhibition is an important ‘OFF-target’ mechanism of drug-induced toxicity in the clinic, contributing to drug attrition in clinical trials and drug withdrawal following approval because of severe adverse events (Will & Dykens, 2014). Read more
Understanding the molecular mechanisms of drug-induced autoimmunity and immunosuppression
Several drugs can affect the immune system, leading to either autoimmunity or immunosuppression. Whilst in some cases, the mechanisms of this are well-described and dose-dependent (e.g. Read more
Epigenomic impact of cancer therapeutics
Cancer drugs frequently target the cellular epigenome leading to changes in transcription by impacting the three RNA polymerases. Read more
Toxicity differences between animal models and humans: the role of the gut microbiota
Animal models are widely used in assessing toxicity of drugs and other xenobiotics (e.g., plant secondary metabolites). Read more
To assess how the mitochondrial tRNAome responds to Toxic Injury and reprogrammes mitochondrial translation
Disruption of mitochondrial function is a common cause of adverse drug reactions (ADR) and mitochondrial toxicity is thought to be responsible for up to 50% of post-market drug withdrawals. Read more
Risky play in UK Preschoolers: understanding the influences to improve children’s health and development
The University of Cambridge ESRC Doctoral Training Partnership [DTP] is pleased to offer an interdisciplinary studentship available for admission in October 2022. Read more
Saskia Jones Memorial Scholarship : “The politics of rape”
On the 29th November 2019, Saskia Jones was murdered in the London Bridge attack at Fishmonger’s Hall. Just two years before her murder, Saskia graduated from ARU with a Criminology and Psychology Honours degree. Read more
Phase transitions underlying viral replication: understanding the selectivity of viral replication factories through the lens of biomolecular condensates
There is an urgent need for new drugs to combat pathogenic viruses. Most existing antivirals inhibit virus attachment/entry or target key enzymes, and new antiviral targets are needed to develop novel treatments and counter antiviral resistance. Read more
Cambridge MRC Doctoral Training Programme – iCASE PhD Studentships
We are offering 5 fully funded MRC Industry Partner (iCASE) PhD studentships commencing in October 2022. Details of the available projects can be found here. Read more
Mapping the conformational signalling landscape of G protein-coupled receptors (GPCRs)
As a research group we are interested in the role that G protein-coupled receptors (GPCRs) play in cellular signalling. We aim at understanding how these membrane embedded receptors function and what external factors influence their behaviour as sensors of the cell. Read more