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We have 22 Neuroscience PhD Projects, Programmes & Scholarships in Cambridge
Neuroscience PhD Projects, Programmes & Scholarships in Cambridge
We have 22 Neuroscience PhD Projects, Programmes & Scholarships in Cambridge
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Ultra-High Field (7T) Magnetic Resonance Imaging (MRI) Development
I lead the 7T MRI physics group in Cambridge. We create new methods to studying the human brain and body using Cambridge’s state-of-the-art Siemens Terra 7T MRI scanner. Read more
Understanding the contribution of sleep dysfunction to the clinical features and pathogenesis of Huntington’s Disease
Sleep dysfunction is prevalent across the spectrum of neurodegenerative disease, and growing evidence suggests that this may exacerbate both the clinical features and pathobiology of these conditions. Read more
Tissue-Specific Vulnerability to Mitochondrial Disease
Mitochondrial diseases are caused by defects in genes required for energy production and oxidative phosphorylation (OxPhos). We find it intriguing that some patients with mitochondrial disease present late in life, with very tissue-specific phenotypes. Read more
Preclinical Development of Corticotroph Releasing Factor-1 (CRF1) Receptor PET Radioligands to Detect ACTH Producing Pituitary Adenomas
Pituitary adenomas are benign tumours which are challenging to detect and localise with conventional imaging methods. Positron Emission Tomography (PET) with amino acid transport tracers is being utilised to improve lesion detection and characterisation. Read more
Metabolic Control of Microglia Regulating Neuronal Functions
Background. Chronic, low grade, inflammation plays a critical role in inflammatory and degenerative central nervous system (CNS) disorders characterised by an irreversible decline of cognitive functions. Read more
Management of Mild Traumatic Brain Injury
(co-supervised with Professor Peter Hutchinson). Although mild Traumatic Brain Injury (concussion) is the commonest form of brain injury, patient pathways are poorly defined, and patients sometimes lack the support required to deal with post-traumatic symptoms. Read more
Investigating gut-immune interactions in Parkinson’s disease
It is now well established that both gastrointestinal dysfunction and immune activation occur in early Parkinson’s disease, and emerging evidence indicates that these processes are linked to faster disease progression. Read more
Integrated Multimodal Analysis for Gaining Enhanced Understanding and Characterization of Dementia
Dementia encompasses various subtypes such as Alzheimer’s disease, vascular dementia, and frontotemporal dementia, each affecting different aspect of brain structure and function. Read more
Inflammation in Frontotemporal Lobar Degeneration: A Multimodal Approach towards New Therapeutics
Neuroinflammation is an important driving mechanism in all diseases caused by frontotemporal lobar degeneration, and predicts clinical progression. Read more
Identifying Novel Genes and Developing Treatments for Children with Inherited Neuromuscular Diseases
Inherited neuromuscular disorders are disabling, progressive, often fatal conditions, representing an enormous unmet medical need with devastating impacts on affected families, the healthcare system, and the economy. Read more
Functional MRI Imaging in Traumatic Brain Injury
CENTER-TBI is a large European project that aims to improve the care for patients with Traumatic Brain Injury (TBI). The work undertaken in Cambridge will examine the role of MRI in routine TBI imaging and this project will focus on the role of resting state functional MRI in TBI imaging. Read more
Exploring Disease Mechanism in Cerebral Small Vessel Disease Ultrahigh Resolution using 7T MRI
Cerebral small vessel disease (SVD), is a major cause of both stroke and vascular dementia. It describes a process where the small arteries and arterioles in the brain become abnormal, and this leads to both acute and chronic ischaemic damage in the brain. Read more
Endoplasmic Reticulum Transport and Morphoregulation in Neuron (Patho) Physiology
The Endoplasmic Reticulum (ER) is a multifunctional organelle, shaped as a contiguous network of membranous pipes extending throughout the cell periphery. Read more
Development of PET Radiotracers of AMPA
Our aim is to develop novel Positron Emission Tomography (PET) radiotracers for imaging the brain. PET is a non-invasive molecular imaging technique which enables visualization and quantification of various biological targets in vivo (e.g., receptor, enzyme). Read more
Assessing the Disease Severity in CADASIL using Patients iPSC-derived Models of the Neurovascular Unit
CADASIL is a hereditary cerebral small vessel disease caused by mutations in the NOTCH3 gene. Small vessel diseases affect the small penetrating arteries and brain capillaries and patients often suffer of migraine, ischaemic stroke, and cognitive decline. Read more
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