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We have 80 Cancer Biology (drug) PhD Projects, Programmes & Scholarships

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Cancer Biology (drug) PhD Projects, Programmes & Scholarships

We have 80 Cancer Biology (drug) PhD Projects, Programmes & Scholarships

Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

  Research Group: Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more

AI-based Identification of New Drug Targets for Personalised Oncology

A fully funded PhD Studentship is available to work with Professor Francesca Ciccarelli, Lead of the Centre for Cancer Genomics and Computational Biology, Bart's Cancer Institute at Queen Mary University of London. Read more

Fully funded PhD studentship in mechanisms of cancer heterogeneity and drug sensitivity

Treatment of cancer with drugs that cause DNA damage often leads to development of the drug tolerance. Recently, we uncovered a novel mechanism of such an adaptation that associates with active generation of hundreds of thousand mutations in chromosomes that prevent drug-triggered DNA damage. Read more

Investigating how dormant senescent cells can drive drug-resistance following chemotherapy

Most anti-cancer chemotherapeutics work by inducing DNA damage and arresting the cell cycle in either G1 or G2 phase. A frequent outcome of this arrest is that cells exit the cell cycle into a state known as senescence. Read more

The role of vitamin D3 in treating skin cancer and preventing drug resistance

  Research Group: Chemistry and Biosciences
During the last decade numerous studies have alluded to vitamin D. 3. playing a role in the prevention of cancer. Recent clinical trials looking at the potential role of vitamin D. Read more

Defining the molecular mechanisms of leukaemia chemotherapies

Chemotherapies are usually the backbone of cancer treatment for either curative or palliative patient care. Multiple therapies can be used for the same disease, with the choice of drug dependent on parameters such as the patient’s age and fitness. Read more

(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more

Vascularisation of tumour organoids for mechanistic and drug development

Gliomas such as are the most common form of brain tumour, a subset Glioblastoma (GBM) are devastating adult brain cancer with high rates of recurrence and treatment resistance. Read more

Development of antibody-drug conjugates (ADCs) for oncology indications

  Research Group: Institute of Cancer Therapeutics
A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells but are not harmful to normal tissue. Read more

Combining CRISPR-screens and AI to Identify Novel Therapeutic Strategies to Target Cancer-Stroma Interactions

A fully funded PhD Studentship is available to work with Dr Angus Cameron, Reader in Cell Signalling and Tumour Cell Biology, Barts Cancer Institute at Queen Mary University London, Dr Otto Morris, Senior Biological Data Scientist at Exscientia, and Professor Pedro Cutillas, Professor of Cell Signalling and Proteomics, QMUL, Barts Cancer Institute at Queen Mary University London. Read more

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

Transcriptome biomarkers and mechanisms of chemoresistance

Project Summary. This project aims to identify biomarkers linked to the most potent multimodal anticancer therapy with the least toxicity to counteract hemoresistance in head and neck squamous cell carcinoma (HNSCC). Read more

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