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We have 11 Cancer Biology (electron microscopy) PhD Projects, Programmes & Scholarships

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Cancer Biology (electron microscopy) PhD Projects, Programmes & Scholarships

We have 11 Cancer Biology (electron microscopy) PhD Projects, Programmes & Scholarships

Obtaining insights into how a signalling hub protein Ras activates multiple effectors

The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. They are highly conserved from yeast to humans, highlighting their fundamental biological roles. Read more

Molecular characterization of Sam68-driven cytoskeletal reorganization

The cytoskeleton is a complex network of various fibres (microtubules, actin, …) that is essential for cells to maintain their shape and internal organization and for their migration. Read more

MSc by Research: Regulation and mechanics in polarized trafficking

Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. Read more

Obtaining an integrated understanding of oncogenic RAS signalling

The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. The physiological importance of RAS signalling is evident as about 25% of all human cancers harbour mutations in ras genes, where kras is most frequently mutated (about 18%) (COSMIC, v94). Read more

Structure and function of enzyme complexes involved in post-transcriptional gene regulation

Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more

Structural and functional characterisation of MALT1 ubiquitination to aid in the development of novel anti-cancer therapies

Nuclear factor-kappa B (NF-kB) is a family of transcription factors that play a crucial role in regulating various cellular processes; primarily related to immune responses, inflammation, and cell survival. Read more
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