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We have 9 Cancer Biology (histone) PhD Projects, Programmes & Scholarships

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Cancer Biology (histone) PhD Projects, Programmes & Scholarships

We have 9 Cancer Biology (histone) PhD Projects, Programmes & Scholarships

Biological pathways supporting the formation and function of chromatin (Scholarship)

Every cell in our body contains the same DNA yet each cell expresses a different set of genes. These changes in gene expression are heavily influenced by histone proteins, their role in packaging DNA into chromatin and the “epigenetic” information they carry. Read more

Understanding gene regulation by HDAC1 complexes in development and cancer

Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more

Cellular mechanisms of equal chromosome segregation and genome stability

The PhD project will investigate how chromosomes segregate equally in each cell division through epigenetic regulation of the centromere, and how cells respond in stress conditions to maintain genome instability. Read more

Investigating intrinsic and extrinsic mechanisms driving plasticity in colorectal cancer metastasis

This CRUK-funded project will commence in September 2024 and has funding for 4 years. The successful candidate will be based at Barts Cancer Institute, Faculty of Medicine and Dentistry (FMD), Charterhouse Square in the City of London. Read more

Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis

Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development. Read more

Mechanisms controlling gene expression in hypoxia and inflammation

Oxygen is one of the most important molecules for life. Every member of the animal kingdom depends on oxygen to help metabolize its food and drive many critical processes in metabolism. Read more

Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy

It is well-established that the molecular mechanisms controlling gene expression are disrupted in cancer cells and work in this area has laid the foundations for targeted cancer therapies. We are interested in the regulatory pathways that control cell proliferation and cell migration and the events that disrupt this control in multiple types of cancer. Read more
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