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We have 8 Cancer Biology (nottingham) PhD Projects, Programmes & Scholarships

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Cancer Biology (nottingham) PhD Projects, Programmes & Scholarships

We have 8 Cancer Biology (nottingham) PhD Projects, Programmes & Scholarships

Understanding transcription factor complexes controlling endothelial cell quiescence and escape from quiescence

Endothelial cell proliferation and lymphatic cell proliferation is initiated during angiogenesis and lymphangiogenesis respectively and are both regulated by the VEGF signalling pathway. With some exceptions, endothelial and lymphatic cells in healthy individuals are quiescent and do not proliferate. Read more

PhD Machine Learning for Medical Imaging

  Research Group: Applied Optics
We are offering a fully funded PhD studentship in the application of machine learning to medical imaging, especially imaging of cancer. Read more

Investigating the communication between cancer cells and cells in the tumour microenvironment to improve our understanding of epigenetic regulatory mechanisms and identify new targets for cancer therapy

It is well-established that the molecular mechanisms controlling gene expression are disrupted in cancer cells and work in this area has laid the foundations for targeted cancer therapies. We are interested in the regulatory pathways that control cell proliferation and cell migration and the events that disrupt this control in multiple types of cancer. Read more

Towards the development of an effective vaccine for advanced prostate cancer

Prostate cancer is the second most frequent cancer in men. Patients with a localised disease are treated with local therapies such as prostatectomy or radiation therapy, whereas patients with metastatic disease are treated with androgen deprivation therapies (ADT). Read more

Structure and function of enzyme complexes involved in post-transcriptional gene regulation

Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics. Read more

Role of BTG1 and BTG2 in acute lymphocytic leukaemia and diffuse large B-cell lymphoma

Acute lymphocytic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) is often associated with small deletions of or point mutations in the highly related BTG1 or BTG2 genes. Read more

Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more
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