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Cancer / Oncology (structural) PhD Projects, Programs & Scholarships

We have 22 Cancer / Oncology (structural) PhD Projects, Programs & Scholarships

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We have 22 Cancer / Oncology (structural) PhD Projects, Programs & Scholarships

Exploiting rare polymorphisms, structural variation, and germline-somatic mutation interactions to explain missing heritability in cancer development.

Understanding cancer heritability has an enormous impact on disease prevention, early detection and tailored treatment. GWAS based on single nucleotide polymorphisms only explain a modest fraction (2-15%) of heritable variation in cancer risk (McCarroll, 2008). Read more

Structural biology of the Ccr4-Not nuclease complex using electron paramagnetic resonance (EPR) spectroscopy and integrative modelling

The ultimate goal in molecular biology is to understand normal physiology and disease processes at atomic resolution. Methods such as x-ray crystallography and NMR spectroscopy have been phenomenally successful in the past decades and continue to be the workhorses of structural biology. Read more

Structural and functional analysis of DNA double strand break repair.

Eukaryotic cells have evolved complex molecular systems in order to detect and repair double-strand breaks (DSBs) of the DNA helix, which can arise from exposure to genotoxic agents or during normal nucleic acid metabolism. Read more

MSc by Research programme - Bringing proteins together with small molecules

Recent advances from the Ciulli Lab and others have contributed to the establishment of a game-changing new modality of chemical intervention into biological system – one that goes significantly beyond the state-of-the-art. Read more

Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

  Research Group: School of Molecular and Cellular Biology
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more

Structure, regulation and dynamics of small G proteins and their interactions with membranes and effector proteins

Our lab are interested in cell signalling via small G proteins of the Ras superfamily. We use a range of biochemical, biophysical and structural approaches to understand these fascinating proteins, which are involved in multiple cellular processes and are often deregulated in diseases such as cancer. Read more

Call for Applications to 10 PhD programmes at the University of Brescia, Italy

Call for Applications to 10 PhD programmes at the University of Brescia, Italy. The Call for Applications to the XXXVII cycle of PhD programmes (duration of 3 years starting on 1st of November 2021) at the University of Brescia is now open until the closing deadline of 4th of August, 2021. Read more

MSc by Research programme - Regulation and mechanics in polarity

Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. Read more

An intelligent scheme to identify novel drug targets through analysing the DNA repairome in drug resistant cancer?

  Research Group: Biomedical Research Group
Research Group. Biomedical Research Group. Proposed supervisory team. Prof Christopher Parris. Theme. Cancer Cell Biology. Summary of the research project. Read more

Elucidating eukaryotic Topoisomerase III activity in homologous recombination

  Research Group: Genome
DNA topoisomerases are a family of enzymes that mediate topological transformations of genomic DNA across all domains of life—facilitating transcription, replication, the dissolution of homologous recombination intermediates, and the segregation of chromosomes in mitosis and meiosis. Read more

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