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Cancer / Oncology (transcription) PhD Projects, Programs & Scholarships

We have 39 Cancer / Oncology (transcription) PhD Projects, Programs & Scholarships

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  Selective control of tRNA gene transcription by steroid receptors and BRCA1.
  Prof R J White, Dr W Brackenbury
Application Deadline: 5 January 2020

Funding Type

PhD Type

BRCA1 is an important tumour suppressor protein with roles in DNA repair. and transcription. BRCA1 binds many tRNA genes, but its role there is.
  (BBSRC DTP) Development of anti-cancer agents and biomarkers that target intrinsically disordered regions of transcription factors and protein kinases
  Prof J Waltho, Dr A Almond
Application Deadline: 31 January 2020

Funding Type

PhD Type

The controlled manipulation of transcription factors, protein kinases and protein phosphatases is central to improving our understanding of cellular processes and, importantly, in the development of next-generation therapeutics for a variety of cancers.
  The role of cyclin-dependent kinases (CDKs) in transcription and cell cycle control.
  Prof C Norbury, Prof S Murphy
Application Deadline: 10 January 2020

Funding Type

PhD Type

Cyclin-dependent kinases (CDKs), including CDK1, 2, 4 and 6, act as master regulators of the cell cycle through phosphorylation of numerous protein targets (1).
  Kinase regulation of HOX transcription factors – a potential target in cancer?
  Research Group: Institute of Cancer Therapeutics
  Prof R Morgan, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

The HOX genes are a family of transcription factors that have a number of important functions in cancer, including cell survival and metastasis.
  Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
  Prof A Sharrocks, Prof M Rattray
Applications accepted all year round

Funding Type

PhD Type

Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity.
  Identifying genomic and epigenetic factors in different subtypes of pancreatic cancer
  Prof J Carroll
Application Deadline: 15 November 2019

Funding Type

PhD Type

Despite recent advances in the treatment of pancreatic adenocarcinoma (PDAC), the median survival remains. Epigenetic pathway alterations are an emerging mechanism for PDA progression.
  Hypoxia links the unfolded proteim response with the DNA damage response
  Prof E Hammond, Prof A Giaccia
Application Deadline: 10 January 2020

Funding Type

PhD Type

THE PROJECT. Regions of hypoxia (insufficient oxygen) occur in most if not all solid tumours and are clinically relevant as they correlate with poor patient prognosis and therapy resistance.
  Transcriptome Pattern Recognition in Pre-Cancer Cells
  Dr M T Teh, Dr L Lacasa
Applications accepted all year round

Funding Type

PhD Type

Background. All cellular processes are tightly regulated by a complex network of interacting biomolecules. Given that mRNA transcription precedes protein translation, change in gene expression levels often precedes visible pathological manifestation.
  (MCRC Non-Clinical) A synthetic lethal strategy to target cell viability to different levels of Notch activity
  Dr M Baron, Dr R Clarke, Prof K R Brennan, Prof S Hubbard
Application Deadline: 1 December 2019

Funding Type

PhD Type

Project summary. Notch is a transmembrane localised signalling receptor utilised both in development and adult stem cell regulation and whose misregulation is frequently involved in different human cancers.
  Actin regulation of nuclear mechanics during DNA repair
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

In eukaryotic cells, the nucleus houses the genomic material and transcription machinery that allows the cell to develop and perform its role.
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