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Cancer / Oncology (structural biology) PhD Projects, Programs & Scholarships

We have 45 Cancer / Oncology (structural biology) PhD Projects, Programs & Scholarships

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  Harnessing Computational and Structural Biology Platforms for Drug Discovery
  Dr D Cole, Dr N Tatum, Dr E Pohl
Application Deadline: 6 March 2020

Funding Type

PhD Type

The spread of low-cost computing and development of data analysis techniques, such as machine learning, promise to improve our understanding of biological disease mechanisms and the design and prioritisation of new pharmaceutical molecules.
  PhD in Structural biology/Protein biochemistry – The role of protein amyloid fibrils in disease
  Dr V Morris
Application Deadline: 14 March 2020

Funding Type

PhD Type

The Morris lab at the University of Canterbury, New Zealand, is seeking a motivated student to carry out investigations of protein aggregation.
  Baculovirus P10 and microtubules; the role of P10 in virus-induced nuclear lysis with possible applications for novel anti-cancer therapies
  Prof L A King, Dr V Bolanos-Garcia
Application Deadline: 20 March 2020

Funding Type

PhD Type

Oxford Brookes University. Faculty of Health and Life Sciences,. Department of Biological and Medical Sciences. 3.5 year, full-time PhD iCASE studentship.
  PhD in Chemical Biology -- Neuropeptide Research -- University of Vienna
  Prof M Muttenthaler
Applications accepted all year round

Funding Type

PhD Type

Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Application Deadline: 1 April 2020

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Fostering development of ‘smart’, responsive therapeutics against cancer-related microRNAs.
  Dr E Bichenkova, Prof D Clarke, Dr H Aojula
Applications accepted all year round

Funding Type

PhD Type

Short functional non-coding microRNAs are implicated in many types of cancer, and thus can be used as biological targets for development of more selective and powerful anticancer therapies.
  Mechanisms of Cancer Stem Cell Survival, Metastasis Formation and Immune Evasion in Cancer
  Dr D Widera
Applications accepted all year round

Funding Type

PhD Type

Recent research suggests that cancer cells within a tumour represent a highly heterogeneous cell population. In particular many tumours contain small percentage of cells that share several characteristics with stem cells.
  CRISPR Screen Multiplexing for Uncharacterised Region Function (SMURF)
  Dr L Prendergast, Dr M Martin, Prof S Wedge
Application Deadline: 6 March 2020

Funding Type

PhD Type

CRISPR-Cas9 screening utilising tiling-sgRNA design across genes, permits functional evaluation of protein domains and precise mapping of critical amino acids.
  Molecular mechanisms of herpesviral infection
  Dr A Golovanov
Applications accepted all year round

Funding Type

PhD Type

Herpes viruses are known to cause a wide range of human diseases, ranging from simple cold sores to cancer, Kaposi Sarcoma. Kaposi Sarcoma, for example, is a type of cancer which affects immunocompromised patients and is endemic in Africa, where it is linked with the spread of HIV infection and AIDS.
  MSc by Research Programme: Deciphering the ubiquitin codes that regulate protein degradation
  Dr Y Kulathu
Application Deadline: 16 July 2020

Funding Type

PhD Type

This course allows you to work alongside our world renowned experts from the School of Life Sciences and gain a ’real research’ experience.
  Targeting DNA repair to overcome cancer therapy resistance
  Prof P McHugh, Prof T Brown
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. DNA cross-linking drugs and radiotherapy (RT) are used to treat a range of tumours including many hard-to-treat cancers (e.g.
  Harnessing Reactive Phosphorylating Agents for Peptide Bioconjugations
  Dr D Hodgson, Prof I Hickson, Prof M Noble
Application Deadline: 6 March 2020

Funding Type

PhD Type

Protein-protein interactions (PPIs) are central to signalling processes associated with many diseases. Disruption of PPI-mediated pathways offers new therapeutic targets, with great potential for selective, potent inhibition because they can mimic native protein structures.
  Structural insights into ligand binding and channel gating in ATP-gated P2X7 receptor
  Research Group: School of Biomedical Sciences
  Dr L H Jiang, Dr S Muench
Applications accepted all year round

Funding Type

PhD Type

P2X7 receptor, belonging to the ATP-gated ion channel P2X receptor family, exhibits distinct functional and pharmacological properties that are crucial for its role in innate immunity and inflammatory diseases and cancers (Jiang et al., 2013; Caseley et al., 2014; Roger et al., 2014; Wei et al., 2018).
  Molecular analysis of the dynamic sulfotyrosine proteome
  Prof C E Eyers, Prof P Eyers, Dr A R Jones
Applications accepted all year round

Funding Type

PhD Type

The survival of an organism depends upon the ability of different cell types to communicate with each other by assembling the correct complexes of proteins at the correct time in the correct place.
  Multi-omics investigations for enhanced understanding of NF-κB mediated drug resistance
  Prof R Goodacre, Prof N Perkins, Prof C E Eyers, Dr A R Jones
Application Deadline: 1 June 2020

Funding Type

PhD Type

We have an established system that can be used to investigate the role of NF-κB signalling in the cancer cell response to DNA replication stress and have generated cell lines which are resistant to treatment with a highly selective and specific CHK1 inhibitor (CCT244747).
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