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Cancer / Oncology (knowledge) PhD Projects, Programs & Scholarships

We have 64 Cancer / Oncology (knowledge) PhD Projects, Programs & Scholarships

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  Cutting off the fuel supply to starve cancer: Identifying metabolic vulnerabilities in cancer
  Dr K Brown, Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

A universal characteristic of all cancer cells is the reprogramming of cell metabolism to provide the energy and building blocks necessary to support proliferation and survival.
  Defining the role of p53 in cancer immunotherapy
  Prof Y. Haupt, Dr S. Haupt, Dr P. Neeson
Applications accepted all year round

Funding Type

PhD Type

Despite clear evidence of an association between the tumour suppressor p53 and immunity, a gap in knowledge exists regarding its role in modulating immune responses, or its value in predicting patient responses to immunotherapy.
  Elucidating the protein interaction network of serum- and glucocorticoid-regulated kinase 1 (SGK1)
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

The phosphoinositide 3-kinase (PI3K) pathway is a master regulator of numerous cellular phenotypes associated with cancer including cell survival, proliferation, growth, altered metabolism and malignant transformation.
  How does amino acid metabolism affect tumour growth?
  Dr L. Cheng
Applications accepted all year round

Funding Type

PhD Type

The effect of diet on tumour growth is hotly debated but poorly characterized. Due to the heterogeneous nature of the tumours, dietary studies in patients with varied genetic background often led to inconclusive outcome.
  Metabolic reprogramming and chemotherapy resistance in triple-negative breast cancer
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

Treatment options for the triple-negative breast cancer (TNBC) subtype of breast cancer are limited to conventional chemotherapy agents.
  The endosomal network in health and disease
  Prof P J Cullen
Applications accepted all year round

Funding Type

PhD Type

Approximately 25% of the human genome encodes for integral membrane proteins (around 5,500 proteins). Efficient intracellular transport of these proteins, and associated proteins and lipids (together termed ‘cargos’), is essential for organelle biogenesis, maintenance, and quality control.
  EPSRC Centre for Doctoral Training in Sustainable Approaches to Biomedical Science: Responsible and Reproducible Research - SABS

Funding Type

PhD Type

Good degree in the Physical or Life Sciences? Interested in biological or medical research? We offer fully-funded PhD places across the Oxford Doctoral Training Centre programmes.
  Understanding the role of HoxA9 in chemotherapy resistance of Acute Myeloid Leukaemia (AML)
  Dr M Esposito
Applications accepted all year round

Funding Type

PhD Type

Acute Myeloid Leukaemia (AML) is a rare but yet deadly form of blood cancer. Genome-wide expression arrays and RNA sequencing have contributed to unravelling the leukaemia signature genes.
  PhD Project related to Spatial Proteomics of Protein quality control or Single Cell Gene Expression Dynamics
  Prof M Knop
Application Deadline: 30 July 2019

Funding Type

PhD Type

Project topic. Protein homeostasis involves control over spatio-temporal distribution of each individual protein species inside a cell.
  Patient experience of the Mesothelioma Stratified Therapy Trial (MiST): a qualitative study
  Prof A Tod, Dr B Taylor
Application Deadline: 3 July 2019

Funding Type

PhD Type

This PhD provides a unique opportunity for a student to conduct a qualitative patient experience health services research study within a complex stratified clinical trial for people with malignant mesothelioma (MM), the Mesothelioma Stratified Therapy Trial (MiST).
  Combining melatonin and omega-3 fatty acids to manage chemotherapy-induced peripheral neuropathy and spinal injury-induced neuropathic pain.
  Prof H Galley, Dr W Huang
Application Deadline: 28 June 2019

Funding Type

PhD Type

Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating complication during cancer treatment, which can lead to chemotherapy drug dose reduction or treatment cessation.
  Understanding the biology of male breast cancer to identify more precise ways to inform clinical decision making for personalised treatment strategies.
  Prof V Speirs, Dr R Abu Eid
Application Deadline: 28 June 2019

Funding Type

PhD Type

Breast cancer (BC) affects both genders but remains understudied in men. This is a concern; research from our and other laboratories show a rise in the number of men receiving a breast cancer diagnosis over the last 3 decades.
  How do cancer cells manipulate protein production rates using different levels of gene expression to deliver proliferative or secretory phenotypes?
  Dr C Miller
Application Deadline: 24 June 2019

Funding Type

PhD Type

The Cancer Research UK Beatson Institute in Glasgow is one of the world-leading centres for cancer research. The Institute provides an outstanding research environment, underpinned by state-of-the-art core services and advanced technologies with special emphasis on imaging, metabolomics and in vivo models of cancer.
  Microscopic Evaluation of Novel Light Activated Molecular Nanomachines
  Dr R Pal
Application Deadline: 31 August 2019

Funding Type

PhD Type

Project Background. An important need for future bio-medical research and fundamental cell biology is the targeted in vivo destruction of selected cells and cell types.
  Doctor of Engineering (EngD): Biomedical imaging and signal processing for the intra-operative detection of cancerous tissue (Lightpoint Medical)
  Prof D Reid, Prof R Thomson
Application Deadline: 30 July 2019

Funding Type

PhD Type

The EngD is an alternative to a traditional PhD aimed at students wanting a career in industry. Students spend about 75% of their time working directly with a company in addition to receiving advanced-level training from a broad portfolio of technical and business courses.
  PhD: Fluorescence imaging, diagnosis, and photodynamic therapy for brain tumours (Laser Research and Therapy Fund) - University of St Andrews
  Prof D Reid, Dr K Wood
Application Deadline: 30 July 2019

Funding Type

PhD Type

Glioblastoma multiforme (GBM) is an aggressive malignant brain tumour with a median survival for adults of only 11 – 15 months. Published studies have shown that prognosis can be improved if near-complete removal of the tumour can be achieved in surgery [do we need to put references?].
  PhD: Fluorescence imaging, diagnosis, and photodynamic therapy for brain tumours (University of St Andrews)
  Prof A Kemp, Prof M Dunn, Prof D Reid
Applications accepted all year round

Funding Type

PhD Type

Glioblastoma multiforme (GBM) is an aggressive malignant brain tumour with a median survival for adults of only 11 – 15 months. Published studies have shown that prognosis can be improved if near-complete removal of the tumour can be achieved in surgery [do we need to put references?].
  The regulation of signalling pathways in cancer initiation by Rho GTPases and the Cytoskeleton
  Dr A Elbediwy, Dr M Stolinski, Mr P Waller, Dr H Ashrafi
Applications accepted all year round

Funding Type

PhD Type

What is the reason why cells can suddenly switch to uncontrolled cellular growth? What causes the normal formation of cellular contacts and organs to stop growing when reaching their normal size to ignore normal signals and multiply uncontrollably?.
  The role of isothiocyanates-derived from natural sources in uveal melanoma chemoprevention (ref: SF18/APP/McDermott)
  Prof A McDermott, Prof M Panagiotidis, Dr G Koutsidis
Applications accepted all year round

Funding Type

PhD Type

Uveal melanoma is the most frequent primary intraocular tumor, in Caucasian adults, and one that is very difficult to treat once it becomes metastatic.
  Activation of targeted DNA Damage Response as a novel therapy for Ovarian Cancer
  Dr E. Sanij, Prof R. Pearson
Applications accepted all year round

Funding Type

PhD Type

High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer and accounts for 70% of all ovarian cancer deaths.
  Analytic methods for detecting and making sense of somatic genomic rearrangements
  Prof A Papenfuss
Applications accepted all year round

Funding Type

PhD Type

Bioinformatics is the application of mathematics, statistics and computational methods to the analysis of molecular biology data.
  Characterize the role of Treacle (TCOF1) in AKT-regulated ribosome biogenesis
  Prof R. Pearson, Dr J Kang
Applications accepted all year round

Funding Type

PhD Type

Ribosomes are essential for cell growth and proliferation, and their biogenesis requires exquisite regulation.
  Clinical cancer bioinformatics: developing new bioinformatics methods for improved analysis of cancer gene hybridisation capture panels
  Prof A Papenfuss
Applications accepted all year round

Funding Type

PhD Type

Bioinformatics is the application of mathematics, statistics and computational methods to the analysis of molecular biology data.
  Control of tissue growth and cancer by the Hippo pathway
  Dr K. Harvey, Dr C Poon
Applications accepted all year round

Funding Type

PhD Type

A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have drawn conclusions about gene function using indirect techniques that only allow us to infer what a gene normally does, without actually watching it work.
  Development of targeted therapy for acute myeloid leukaemia with mutations in isocitrate dehysdrogenase
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

Acute Myeloid Leukaemia (AML) is an aggressive disease with poor prognosis and development of novel treatment options is urgently needed.
  Exploration of novel approaches to anti-cancer treatment: manipulation of mutant p53
  Prof Y. Haupt, Dr S. Haupt
Applications accepted all year round

Funding Type

PhD Type

P53 is the most mutated gene in human cancer, affecting about half the cases of human cancer. We have recently identified novel regulators of mutant p53 using sophisticated loss of function whole genome high through put screen (image 1).
  Finding a therapy for triple negative breast cancer patients
  Dr K. Britt
Applications accepted all year round

Funding Type

PhD Type

Triple negative breast cancers are a poor prognosis breast cancer with limited therapeutic options as they do not express estrogen receptors, progesterone receptors or Her2.
  Fishing for metabolic clues: Role of the Hippo/Yap pathway in reprogramming metabolism in liver cancer
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

The Hippo/Yap pathway is an evolutionarily conserved cascade that plays a fundamental role in governing organ size control, stem cell homeostasis and cancer.
  How is fate determined during T cell development, leukemogenesis and responses?
  Dr S. Russell
Applications accepted all year round

Funding Type

PhD Type

Understanding how cell fate programming works will lead to improved diagnostic and therapeutic opportunities for leukemia, and to improved immunotherapies for cancer and infectious disease.
  Immunostaging for melanoma to accurately predict the risk of relapse after surgery
  Prof A Papenfuss
Applications accepted all year round

Funding Type

PhD Type

This project will utilise a large biobank of clinically annotated samples from patients with melanoma at high risk of relapse after surgery to develop a signature that predicts risk of relapse.
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