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Cancer / Oncology (metabolism) PhD Projects, Programs & Scholarships

We have 29 Cancer / Oncology (metabolism) PhD Projects, Programs & Scholarships

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  Targeting steroid metabolism to block colorectal cancer proliferation
  Dr P Foster, Dr L Cox
Applications accepted all year round

Funding Type

PhD Type

Our group is a world leader in targeting specific aspects of steroid metabolism to block cancer growth. Our research has been instrumental in the successful pre-clinical and clinical development of various novel anti-cancer compounds.
  Development of a novel 3D gut-microbiota model for the assessment of absorption and metabolism of health supplements and therapeutic drugs
  Dr P Ragazzon
Application Deadline: 10 December 2019

Funding Type

PhD Type

The gut epithelium is a complex setting of intestinal cells and epithelial cells filled with transporters, enzymes and channels; these cells are then populated by bacteria (microbiota) that help with the metabolism of nutrients and transport into the blood stream.
  Fishing for metabolic clues: Role of the Hippo/Yap pathway in reprogramming metabolism in liver cancer
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

The Hippo/Yap pathway is an evolutionarily conserved cascade that plays a fundamental role in governing organ size control, stem cell homeostasis and cancer.
  How does amino acid metabolism affect tumour growth?
  Dr L. Cheng
Applications accepted all year round

Funding Type

PhD Type

The effect of diet on tumour growth is hotly debated but poorly characterized. Due to the heterogeneous nature of the tumours, dietary studies in patients with varied genetic background often led to inconclusive outcome.
  Metabolic rewiring in liver cancer: Role of oxidative stress and the Nrf2 pathway
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Many of the major risks factors for developing liver cancer such as alcohol, obesity, smoking and toxin exposure share in common a role for oxidative stress.
  Development of novel artificial intelligence algorithms for network wide metabolic flux analysis with stable isotope tracers
  Dr C Ludwig, Dr S He
Applications accepted all year round

Funding Type

PhD Type

The efficient function of the metabolic network in eukaryotic cells relies on its separation into a number of closely-linked but metabolically distinct compartments.
  Metabolic control of T cell function
  Dr S Dimeloe
Applications accepted all year round

Funding Type

PhD Type

Current research interests in Sarah Dimeloe’s lab focus on the metabolism and interlinked immune function of T lymphocytes in health and disease.
  Cutting off the fuel supply to starve cancer: Identifying metabolic vulnerabilities in cancer
  Dr K Brown, Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

A universal characteristic of all cancer cells is the reprogramming of cell metabolism to provide the energy and building blocks necessary to support proliferation and survival.
  Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
  Dr S Papa
Applications accepted all year round

Funding Type

PhD Type

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow.
  Non-invasive Mapping of Oxygen Extraction Fraction in Patients with Breast Cancer: Development of Novel Multi-Parametric Relaxometry Magnetic Resonance Imaging (MRI) Methods
  Dr J He, Dr Y Masannat, Prof D Lurie
Applications accepted all year round

Funding Type

PhD Type

This project aims to translate, optimise and extend quantitative oxygen extraction fraction mapping based on oxygen enriched air inspiration and magnetic resonance (MR) relaxometric imaging for human application.
  Metabolic Reprogramming in Liver Cancer: delineating the role of reactive oxygen species (ROS) in tumour development
  Prof T. Tiganis
Applications accepted all year round

Funding Type

PhD Type

The Tiganis Laboratory is seeking a highly enthusiastic student to conduct research in cancer metabolism and obesity-associated liver cancer.
  Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Prof P Loadman
Applications accepted all year round

Funding Type

PhD Type

Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis.
  An intelligent scheme to identify novel drug targets through analysing the DNA repairome in drug resistant cancer?
  Research Group: Biomedical Research Group
  Prof C Parris
Applications accepted all year round

Funding Type

PhD Type

Research Group. Biomedical Research Group. https://www.anglia.ac.uk/science-and-engineering/research/institutes-and-groups/biomedical.
  Stimulating the sirtuin family in the treatment of cancer.
  Dr P Ragazzon
Applications accepted all year round

Funding Type

PhD Type

Every year, thousands of people face cancer diagnosis. Survival rates are high, but many face devastating disabilities and long-term side effects resulting from currently treatments.
  PhD program in Molecular Inflammation, Molecular Medicine and Advanced Medical Biomarker Research

Funding Type

PhD Type

Projects starting March 1, 2020. Application deadline. September 15, 2019.
  Elucidating the protein interaction network of serum- and glucocorticoid-regulated kinase 1 (SGK1)
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

The phosphoinositide 3-kinase (PI3K) pathway is a master regulator of numerous cellular phenotypes associated with cancer including cell survival, proliferation, growth, altered metabolism and malignant transformation.
  Metabolic reprogramming and chemotherapy resistance in triple-negative breast cancer
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

Treatment options for the triple-negative breast cancer (TNBC) subtype of breast cancer are limited to conventional chemotherapy agents.
  Using T cells to eradicate cancer
  Prof T. Tiganis
Applications accepted all year round

Funding Type

PhD Type

The Tiganis Laboratory is seeking a highly enthusiastic student to conduct research in immuno-oncology and the development of novel immunotherapeutic approaches for the treatment of cancer.
  Activity based proteomic probes for profiling CYP2W1 in cancer tissues
  Research Group: Institute of Cancer Therapeutics
  Dr C Sutton, Dr K Pors
Applications accepted all year round

Funding Type

PhD Type

Cytochromes P450 (CYPs) are a superfamily of mixed function oxidases of which CYP1-4 subfamily members are unique in their ability to oxidise drugs.
  Understanding drug-resistance in myeloid cancer
  Dr P Laslo
Applications accepted all year round

Funding Type

PhD Type

Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory.
  Actin regulation of nuclear mechanics during DNA repair
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

In eukaryotic cells, the nucleus houses the genomic material and transcription machinery that allows the cell to develop and perform its role.
  HDAC inhibitors: a potential therapy for breast cancer?
  Dr C Staton, Dr B Corfe
Applications accepted all year round

Funding Type

PhD Type

Radiation resistance, due to hypoxia, remains a major cause of mortality in the treatment of breast cancer.
  High-throughput mechanobiology
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

Cancer research has traditionally focused upon extra- or intra-cellular biochemical signals, and their relation to cancer development and metastasis.
  Treating cancer by targeting the mechanical properties of cells
  Dr A Gad
Applications accepted all year round

Funding Type

PhD Type

Cancer development is marked by massive increase of matrix fibres around tumor cells, which changes the mechanical properties of the tissue and is used to diagnose tumours by manual palpation.
  Determining the translational potential of the highly phosphorylated proto-oncogene PBF
  Dr V Smith
Applications accepted all year round

Funding Type

PhD Type

In order to translate the many molecular alterations now detectable in human tumours into effective clinical management we need to fully understand their impact on tumour biology.
  Polo-like kinase inhibitors for targeted therapy in adrenocortical carcinoma
  Dr C L Ronchi, Dr P Foster
Applications accepted all year round

Funding Type

PhD Type

Adrenocortical carcinoma (ACC) is a rare cancer with a generally poor prognosis and partially unknown pathogenesis.
  Repairing DNA Damage in Response to BRAF Mutation
  Dr C McCabe, Prof G Stewart
Applications accepted all year round

Funding Type

PhD Type

We are the leading thyroid cancer research group in the UK; we work on other neoplasias as well, including breast and head and neck etc.
  Novel bone-targeted therapy for treatment against dormant myeloma cells
  Dr M Lawson, Dr A Chantry
Application Deadline: 1 September 2019

Funding Type

PhD Type

Multiple myeloma is a cancer of differentiated B-lymphocytes (plasma cells) that grow in the bone marrow. Despite the development and use of more effective drugs in the treatment of myeloma it remains an incurable disease, given that current treatment regimens are not able to eradicate all tumour cells.
  Novel niclosamide-bisphosphonate vectors as bone-targeted therapy for multiple myeloma
  Dr M Lawson, Dr A Chantry
Application Deadline: 1 September 2019

Funding Type

PhD Type

Myeloma remains an incurable cancer despite improvements in survival outcomes over the last few years, due to the development of better therapies.
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