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Cancer / Oncology PhD Projects, Programs & Scholarships

We have 289 Cancer / Oncology PhD Projects, Programs & Scholarships

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  LaNts and laminins in breast cancer
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

The laminins are a family of proteins that make up part of specialised regions of extracellular matrix termed basement membranes.
  LaNts in wound repair, stem cell activation and squamous cell carcinoma
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

The Laminin N terminus proteins (LaNts) are a relatively unstudied protein family that are related to netrins and laminins. To date there are only two publications and one preprint about the LaNt proteins in the literature which means there is a massive potential to do novel, ground breaking research in this area.
  Taking control of cancer-associated splicing switches
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

In cancer, numerous changes to protein expression occur. Some of these are the result of changes to gene transcription or mRNA degradation rates, however, it has increasingly apparent that changes to alternative splicing profile are a key driver of cancer progression.
  Characterization and functional analysis of a novel cancer-associated gene
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

In order to identify new candidate cancer-related genes, our lab developed a bioinformatics “guilt-by-association” method to identify and rank genes that are co-expressed with known cancer-related genes.
  Targeting ageing: Genes and compounds with pro-longevity, health-preserving effects
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

Ageing is arguably the major biomedical challenge of the 21st century. In model organisms, the process of ageing can be manipulated by both genetic manipulations and dietary interventions.
  Exploring the role of meiotic proteins in cancer
  Dr U McClurg
Applications accepted all year round

Funding Type

PhD Type

Cancer is one of the main causes of death worldwide. The main challenge is the development of treatments specifically targeting cancers without killing healthy cells.
  Molecular analysis of the dynamic sulfotyrosine proteome
  Prof C E Eyers, Prof P Eyers, Dr A R Jones
Applications accepted all year round

Funding Type

PhD Type

The survival of an organism depends upon the ability of different cell types to communicate with each other by assembling the correct complexes of proteins at the correct time in the correct place.
  Biomolecular Science and Medicinal Chemistry Division PhD project: Proteases in the ubiquitin system – from molecular mechanisms to the development of novel inhibitors
  Dr I Dreveny
Applications accepted all year round

Funding Type

PhD Type

Ubiquitin is a posttranslational modifier that tags substrate proteins for degradation and regulates virtually all known cellular processes.
  Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes
  Dr G S Winkler
Applications accepted all year round

Funding Type

PhD Type

Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease.
  Gene Regulation by the KAT6A/MOZ Histone Acetyltransferase
  Prof D Heery
Applications accepted all year round

Funding Type

PhD Type

The human KAT6A and KAT6B genes encode the nuclear proteins MOZ and MORF, which are key gene regulators in development of blood, brain and other tissues.
  Role of BTG1 and BTG2 in acute lymphocytic leukaemia and diffuse large B-cell lymphoma
  Dr G S Winkler
Applications accepted all year round

Funding Type

PhD Type

Acute lymphocytic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) is often associated with small deletions of or point mutations in the highly related BTG1 or BTG2 genes.
  Structure and function of enzyme complexes involved in post-transcriptional gene regulation
  Dr G S Winkler
Applications accepted all year round

Funding Type

PhD Type

Many proteins in human cells function as part of high molecular weight multi-subunit assemblies. The structure and function of such large molecular machines is often difficult to characterise due to their complexity, low abundance and structural dynamics.
  Targeting anticancer drugs to the intestinal lymphatic system for improved treatment of cancer
  Dr P Gershkovich
Applications accepted all year round

Funding Type

PhD Type

The lymphatic system plays an important role in the pathophysiology of cancer as it can be both a site for the primary cancer and the major route of metastasis.
  Targeting cannabinoids to the gut-associated lymphoid tissue (GALT) for improved treatment of autoimmune diseases
  Dr P Gershkovich
Applications accepted all year round

Funding Type

PhD Type

Autoimmune diseases are conditions that are triggered by the immune system initiating an attack on the body’s own molecules. The causes of such attacks in most cases are unknown, but a number of studies suggest that they are associated with factors such as genetics, infections and environment.
  Understanding genome regulation via DNA methylation and enhancer interactions in cancer
  Dr M Parry, Dr A Chatterjee
Applications accepted all year round

Funding Type

PhD Type

Gene expression changes are likely in cancer patients, as well as methylation changes. However, there is a paucity of enhancer data for cancer patients.
  EPSRC Centre for Doctoral Training in Sustainable Approaches to Biomedical Science: Responsible and Reproducible Research - SABS

Funding Type

PhD Type

Good degree in the Physical or Life Sciences? Interested in biological or medical research? We offer fully-funded PhD places across the Oxford Doctoral Training Centre programmes.
  Artificial intelligence and machine learning for clinical prediction: Evaluating design, conduct, reporting and 'spin' #NDORMS-2020/3
  Prof G Collins, Dr M Schlussel, Dr P Dhiman, Dr J de Beyer
Application Deadline: 10 January 2020

Funding Type

PhD Type

1. Professor Gary Collins. 2. Dr Michael Schlussel. 3. Dr Paula Dhiman. 4. Dr Jennifer de Beyer. Artificial intelligence (AI) and machine learning (ML) are increasingly seen as solutions to many healthcare problems (e.g., for risk prediction, imaging), and the pace of development is showing no signs abating.
  Molecular mechanisms regulating the developmental plasticity of pancreatic cancer cells #NDORMS-2020/6
  Dr S Pauklin
Application Deadline: 10 January 2020

Funding Type

PhD Type

Pancreatic cancers are among the most lethal malignancies in human due to highly metastatic characteristics and the poor responsiveness to currently used cancer therapeutics.
  A molecular analysis of centrioles, centrosomes and cilia
  Prof J Raff
Application Deadline: 10 January 2020

Funding Type

PhD Type

Centrioles are barrel-shaped structures that organise the assembly of two crucial cell organelles. centrosomes and cilia.
  Development and validation of new tools to dissect the molecular functions of caspases in non-apoptotic scenarios.
  Dr L A Baena-López
Application Deadline: 10 January 2020

Funding Type

PhD Type

The apoptotic function of caspases has overshadowed other important roles linked to these evolutionary conserved enzymes during many years.
  Homologous recombination: when, where and how does it act?
  Dr F Esashi
Application Deadline: 10 January 2020

Funding Type

PhD Type

Our genomic DNA is constantly challenged by numerous environmental stresses, such as radiation and genotoxic drugs, as well as those arising from normal processes of cell growth, including DNA replication and transcription.
  Intronic gene silencing: new mechanism of gene expression regulation and its relevance to cancer
  Dr M Gullerova
Application Deadline: 10 January 2020

Funding Type

PhD Type

Mammalian cells employ small RNAs (sRNAs) molecules to regulate gene expression in a pathway known as RNA interference (RNAi). Transfer RNAs (tRNAs) are essential for translation but also serve as a source for tRNA-derived small RNAs (tsRNAs).
  Molecular mechanisms of genome stability and cancer
  Dr D Ahel
Application Deadline: 10 January 2020

Funding Type

PhD Type

The maintenance of complete and undamaged genome is critical for survival. However, DNA is a fragile structure susceptible to DNA damage.
  Regulation of genome stability and human disease
  Dr I Ahel
Application Deadline: 10 January 2020

Funding Type

PhD Type

Poly(ADP-ribose) polymerases (PARPs) are the major family of enzymes that synthesize an abundant posttranslational protein modification called ADP-ribosylation.
  Safe-guarding genome integrity during mammalian cell division
  Dr U Gruneberg
Application Deadline: 10 January 2020

Funding Type

PhD Type

The key goal of cell division is the correct segregation of the genetic material over multiple generations. Failure of this process can result in cell death or trigger tumorigenesis.
  The role of cyclin-dependent kinases (CDKs) in transcription and cell cycle control.
  Prof C Norbury, Prof S Murphy
Application Deadline: 10 January 2020

Funding Type

PhD Type

Cyclin-dependent kinases (CDKs), including CDK1, 2, 4 and 6, act as master regulators of the cell cycle through phosphorylation of numerous protein targets (1).
  Unusual RNA/DNA structures in health and disease
  Dr N Gromak
Application Deadline: 10 January 2020

Funding Type

PhD Type

Unusual RNA/DNA structures (R-loops) are formed when the RNA hybridizes to a complementary DNA strand, displacing the other DNA strand in this process.
  Designing novel composite polysaccharide nanoparticles for combined diagnosis and treatment of cancers
  Dr E Barbu, Dr A Lalatsa
Applications accepted all year round

Funding Type

PhD Type

Cancer continues to impose a vast burden with regard to financial costs as well as human suffering but the progress in its treatment is hindered by the limited selectivity and significant side-effects that the current chemotherapy demonstrates, representing a major challenge for modern drug delivery.
  Targeting the Gas6-TAM receptor signalling pathway in cancer
  Dr S Hafizi
Applications accepted all year round

Funding Type

PhD Type

Applications are invited for a self-funded 3 year full-time PhD project, to commence in October 2019 or February 2020. The PhD will be based in the School of Pharmacy and Biomedical Sciences and will be supervised by Dr Sassan Hafizi.
  Neuropeptide Research - PhD Opportunity at a World Class Institution
  Assoc Prof M Muttenthaler, Assoc Prof C Schroeder, Assoc Prof I Vetter
Applications accepted all year round

Funding Type

PhD Type

We are seeking talented and highly motivated PhD candidates for the following multidisciplinary project. Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases.
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