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University of Leeds Cancer / Oncology PhD Projects, Programs & Scholarships

We have 15 University of Leeds Cancer / Oncology PhD Projects, Programs & Scholarships

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  A ‘Metastasis-On-A-Chip’ Microphysiological Model of Cancer Metastasis to Bone
  Dr M Amer, Dr V Pensabene, Prof F Meldrum
Application Deadline: 1 July 2020

Funding Type

PhD Type

Bone is a frequent site of cancer metastases and usually indicates poor clinical prognosis. Metastasis of tumour cells in the bone marrow is a dynamic process, and cell behaviour is regulated by three-dimensional (3D) cell-cell and cell-matrix interactions with its microenvironment.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Application Deadline: 1 June 2020

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Epigenetics and Cancer: Development of Novel Tools to Determine how Aberrant V(D)J Recombination Reactions Cause Leukaemia
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Applications accepted all year round

Funding Type

PhD Type

V(D)J recombination generates a highly diverse set of immunoglobulin and T cell receptor genes to enable vertebrates to fight a vast range of infections.
  Structural insights into ligand binding and channel gating in ATP-gated P2X7 receptor
  Research Group: School of Biomedical Sciences
  Dr L H Jiang, Dr S Muench
Applications accepted all year round

Funding Type

PhD Type

P2X7 receptor, belonging to the ATP-gated ion channel P2X receptor family, exhibits distinct functional and pharmacological properties that are crucial for its role in innate immunity and inflammatory diseases and cancers (Jiang et al., 2013; Caseley et al., 2014; Roger et al., 2014; Wei et al., 2018).
  Using AI to combine genomic with pathology images to improve lymphoma diagnosis
  Research Group: School of Molecular and Cellular Biology
  Prof D R Westhead, Dr R Tooze
Application Deadline: 15 June 2020

Funding Type

PhD Type

Primary Supervisor. Prof David Westhead, Faculty of Biological Sciences (https://biologicalsciences.leeds.ac.uk/molecular-and-cellular-biology/staff/154/professor-david-r-westhead).
  Enhancing Oncolytic Virus-induced Immunotherapy using Eicosapentaenoic Acid (EPA)
  Dr F Errington-Mais, Dr MA Volpato
Applications accepted all year round

Funding Type

PhD Type

Breast cancer is the most commonly diagnosed cancer in women with triple-negative breast cancer (TNBC) having the worst prognosis, highest death rate and lowest overall survival.
  Epigenetic therapy using ultrasound-mediated microbubble drug delivery for cancer treatment
  Dr E Valleley, Dr L Coletta
Applications accepted all year round

Funding Type

PhD Type

The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (such as DNA methyltransferase inhibitors), as a potential combination therapy for colorectal cancer (CRC).
  Gastroesophageal reflux in respiratory disease: pathogenic role and improved management
  Prof L Houghton
Applications accepted all year round

Funding Type

PhD Type

Gastroesophageal reflux (GER) is associated with many lung diseases, including but not limited to idiopathic pulmonary fibrosis (IPF), non-IPF interstitial lung disease (ILD), chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), non-CF bronchiectasis, asthma and idiopathic chronic cough.
  Identification and functional characterisation of BRIT1/MCPH1 synthetic lethal genes to treat breast and ovarian cancer
  Dr S Bell, Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Women who have undergone surgery for breast and ovarian cancer often have additional chemotherapy to kill residual cancer cells and prevent recurrence.
  International PhD Academy: Medical Research

Funding Type

PhD Type

Our vision is to impact locally, nationally and globally on biomedical and clinical research with a primary emphasis on health outcomes.
  Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
  Dr S Papa
Applications accepted all year round

Funding Type

PhD Type

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow.
  Oncogenic mechanisms causing malignant transformation of lymphoid cells
  Prof U Klein
Applications accepted all year round

Funding Type

PhD Type

Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy.
  The functional characterization of the tumour suppressor gene CSMD1 in breast cancer
  Dr S Bell
Applications accepted all year round

Funding Type

PhD Type

CUB and Sushi multiple domains protein 1 (CSMD1) maps to 8p23, a region deleted in many cancers including breast cancer. Our previous work has established that CSMD1 is an independent prognostic marker in ductal breast cancer, with reduced expression associated with high tumour grade and poor survival1.
  Oncogenic reprogramming of immune cells, a novel mechanism of drug-resistance.
  Dr P Laslo
Applications accepted all year round

Funding Type

PhD Type

Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory.
  New approaches for studying and understanding Cancer
  Research Group: Molecular and Nanoscale Phsyics
  Prof SD Evans
Applications accepted all year round

Funding Type

PhD Type

One of the key questions in cancer research is what drives cells to switch from a normal healthy state to a cancerous one, in which they continually divide and reproduce.
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