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University of Manchester Cancer / Oncology PhD Projects, Programs & Scholarships

We have 17 University of Manchester Cancer / Oncology PhD Projects, Programs & Scholarships

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Showing 1 to 10 of 17
  (BBSRC DTP CASE) Development of novel peptide hydrogel therapies for endometriosis and endometrial cancer
  Prof K Marshall, Prof A Miller, Dr D Fischer
Application Deadline: 31 January 2019
Background. Endometrial cancer and endometriosis are common gynaecological disorders, which arise from the uterine lining. Cancer develops by glandular cell differentiation, whilst implantation and growth of endometrial-like tissue in endometriosis induces a chronic inflammatory reaction causing pain and infertility.
  (BBSRC DTP) Morphological control of cell fate, behaviour and function
  Dr S Herbert, Prof N Papalopulu, Dr M Baron
Application Deadline: 31 January 2019
Tissue formation critically depends on the appropriate assignment of specialised cell fates and behaviours. The traditional perspective of these competitive decisions is that cells first perceive extrinsic signalling cues, decide their fate and then act appropriately (i.e.
  (BBSRC DTP) Probing Regulatory Networks setting Notch signalling levels in vivo in Drosophila and Zebrafish.
  Dr M Baron, Dr S Herbert, Prof S Hubbard
Application Deadline: 31 January 2019
Development of organisms and maintenance of healthy tissues depends on proper control of cell to cell communication networks that control cell fate and behaviour.
  A functional proteomic approach to reveal how receptor tyrosine kinases trafficking specifies cancer cell responses
  Dr C Francavilla, Prof S Hubbard
Applications accepted all year round
Background and goals. Cells respond appropriately to their surroundings by activating plasma membrane spanning receptors like Receptor Tyrosine Kinases (RTKs) and thereby adapting long-term outputs (e.g.
  Analysis of the role of microRNAs in the regulation of NF-kappaB dynamics and function
  Prof M White, Dr A P Gilmore
Applications accepted all year round
NF-κB is one of most important cell signalling systems in the body and controls inflammation and cell fate. NF-κB signalling involves complex dynamics involving oscillations of the NF-κB complex between the nucleus and cytoplasm in activated cells.
  Developing Blood Cell Production Platforms for Therapeutic Applications
  Prof G Lacaud, Prof A J Dickson
Applications accepted all year round
Generation and modification of blood cells ex vivo or in vitro harbours a huge potential in cell based therapies and regenerative medicine.
  Developing preclinical models for cancer therapeutics using biomaterials and omics technologies
  Prof A Nicolaou, Dr A Tirella
Applications accepted all year round
Hydrogels are biomaterials used to prepare in vitro models used to study many biological processes. These materials can be selectively modified to present different physical, chemical and mechanical properties to mimic the ones of the extracellular matrix present in different tissues.
  ERK5 drives immune suppression in cancer
  Dr C Tournier, Dr K Finegan
Applications accepted all year round
The inflammatory microenvironment is arguably one of the most influential components of most, if not all, tumours (1).
  How an IFNγ target gene mediates resistance to immunotherapy
  Dr A Hurlstone, Prof K Williams, Dr J Bruce
Applications accepted all year round
Metastatic melanoma, a highly aggressive form of skin cancer, can respond well to immunotherapy with immune checkpoint inhibitors, but there are still a significant proportion of patients not benefitting or for whom benefits are not durable.
  Linear Poisson Modelling Independent Component Analysis of DESI Mass Spectral Tissue Images
  Dr A McMahon, Dr N Thacker
Applications accepted all year round
Desorption Electrospray Ionisation - Mass Spectrometry Imaging (DESI – IMS) allows mass spectra to be acquired from an. array of.
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