Alzheimer’s disease is one of the greatest healthcare challenges facing 21st century society. AD is associated with formation of fibrils and plaques in brain tissue that impair proper functioning of neurons.
The PhD will be based within the Cardiff Catalysis Institute (CCI) (www.cf.ac.uk/cci) which is one of the leading centres for catalyst research focussed on improving the understanding of catalysis, developing new catalytic processes with industry and promoting the use of catalysis as a sustainable 21st century technology.
Metal-organic frameworks (MOFs) are a class of microporous crystalline materials made of organic ligands linked to metal nodes, self-assembled to form infinite frameworks with nanoscale pore and channels.
Background. Mitochondrial Thymidine Kinase 2 (TK2) catalyses transfer of a γ-phosphate group from ATP to the 5′-hydroxyl group of thymidine, deoxycytidine, or deoxyuridine to form their 5’-mono-phosphates.