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We have 15 Cell Biology PhD Projects, Programmes & Scholarships in Cardiff
Cell Biology PhD Projects, Programmes & Scholarships in Cardiff
We have 15 Cell Biology PhD Projects, Programmes & Scholarships in Cardiff
Last chance to apply
Understanding the dynamics of NFkappaB complex formation using combined in situ and in silico approaches.
Protein-protein interactions (PPIs) play crucial roles in many biological processes with ~20,000 proteins making ~650,000 interactions in humans alone. Read more
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Role of cholesterol and cholesterol metabolites in brain development
Cholesterol is known to be vital in the developing brain, both as a membrane component and signalling molecule. It is a major constituent of myelin, is needed to form synapses, and is critical for signalling via Sonic Hedgehog, which controls how, where and when different parts of the brain are formed. Read more
Molecular mechanisms of iron related tumourigenesis and cachexia
Hamaratoglu Lab studies cell-cell signalling in development and tumourigenesis. We take advantage of outstanding genetic tools in Drosophila, and use larval imaginal discs as model epithelial organs. Read more
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Investigating regulation of lysosomal proteolysis by Kunitz domain proteins and their role in healthy ageing.
Kunitz domains are a large group of small active domains found within proteins throughout the natural world known to function as protease inhibitors. Read more
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Drosophila models for mechanistic analysis of Huntingtin function in neurodegeneration
Background. Huntington’s Disease (HD) is a devastating neurodegenerative disorder caused by expansion of the "CAG repeat" in the Huntingtin (HTT) gene, which produces a mutant form of the Huntingtin protein (mHTT). Read more
Determining molecular mechanisms of action of anti-obesity medications in neural stem cells and neurons
medications in neural stem cells and neurons. Project Description. (Max 700 words). Project Overview Due to the increasing prevalence of obesity, Anti-Obesity Medications (AOMs) are among the most frequently prescribed drugs in human medicine. Read more
Sperm derived factors involved in egg activation.
At the fertilization in mammals the sperm initiates a series of Ca2+ oscillations by introducing PLCzeta into the egg. These Ca2+ oscillations activate embryo development. Read more
Molecular mechanisms underlying the anti-atherogenic actions of natural products
Atherosclerosis, the underlying cause of myocardial infarction, stroke and peripheral vascular disease, is responsible for most deaths in the western world with mortality increasing at a marked rate in developing. Read more
Drug discovery leading to novel therapeutic avenues for the treatment of acute pancreatitis and pancreatic cancer
Acute pancreatitis is often a fatal human disease. The risk of developing pancreatic cancer is significantly increased in patients with chronic pancreatitis. Read more
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Endocytic profiling tools for complex in vitro 3D cell models to improve nanotherapeutic delivery.
The last three decades has witnessed the spending of billions of pounds on attempts to develop peptides and nucleotides into clinically effective therapeutics. Read more
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The curious case of Turritopsisdohrni jellyfish – elucidating epigenetic principles of immortality
This project aims to explore the molecular mechanisms behind the biological immortality of Turritopsis dohrnii, commonly known as the 'immortal jellyfish.'… Read more
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Maintaining human lung - the role of fibroblasts and lipids in alveolar regeneration
The human lung is built by more than 50 cell types, which cooperate to create a beautiful organ essential for us to breathe. Critically, lack of regenerative capacity is a key feature of many chronic lung diseases and ageing. Read more
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Developing methods for differential mRNA secondary structure analysis
RNA is not a simple intermediate molecule between DNA and protein, but can play an important role in regulating cellular processes. Read more
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Investigating the structure, function and dynamics of the P2X7 receptor ballast domain
P2X7 receptors are ATP-activated cation channels predominantly expressed in immune cells. Read more
Develop Cutting-Edge Peptide Therapies to Fight Antimicrobial Resistance in Eye Infections'
. The cornea, a dome-shaped, transparent tissue at the front of the eye, is crucial for vision. Corneal infections, such as bacterial keratitis (BK), are among the leading causes of unilateral blindness worldwide. Read more
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