Sepsis is a major health care burden with unacceptably high rates of mortality. The underlying pathogenic mechanisms are multifactorial involving dysfunctional immune and metabolic responses to infection.
Outstanding graduate scientists are invited to apply for a PhD Studentship to study the molecular mechanisms that cause detrimental pulmonary vascular remodelling in babies born with univentricular hearts, and to develop treatments that will prevent this problem and protect the infant lungs through childhood.
Background. Cardiac arrhythmias are a leading cause of mortality and long-term morbidity worldwide. Over 25% of these originate in the heart’s electrically-autonomous (pacemaking) cells without a detectable heart attack.
Giant cell arteritis (GCA) is the commonest primary systemic vasculitis, occurring exclusively after 50yrs. Irreversible ischaemic complications, including blindness, occur in 19% of UK patients, despite prompt treatment.
Dr M Cross, Prof J Schneider, Prof H Poptani, Dr B Wilm
21 January 2019
Cardiovascular disease (CVD) is the leading cause of death in the western world. The incidence and prevalence of CVD is highest among the elderly due to the deleterious effects of advancing age on the heart and blood vessels1.
Prof P Murray, Prof J Schneider, Prof H Poptani, Dr B Wilm
21 January 2019
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). The strong association between CKD and CVD has been recognised for many years, but the mechanisms by which CKD causes CVD are largely unknown.