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We have 30 Cell Biology (cardiovascular disease) PhD Projects, Programmes & Scholarships

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Cell Biology (cardiovascular disease) PhD Projects, Programmes & Scholarships

We have 30 Cell Biology (cardiovascular disease) PhD Projects, Programmes & Scholarships

Application and development of bioinformatics and network theory methods in cardiovascular disease research and pharmacovigilance

To be able to discover novel drug targets we aim to develop software based on network theoretic approaches that are capable to identify mediators and pathways involved in the pathomechanism of various cardiovascular diseases by the analysis of datasets assessed with high throughput molecular biological techniques (e.g. Read more

Examining the mechanisms that cause cardiovascular disease by studying the heart or adipose tissue

Heart failure has a serious impact on our society and once diagnosed has a poor survival rate. In the United Kingdom, there are about 1.5 million people living with the after-effects of a heart attack. Read more

NIHR Leeds BRC: Force sensing mechanisms of haemostasis in heart failure and diabetes

Since the original identification of the role of PIEZO1 in vascular integrity and endothelial cell biology by our group in Leeds in 2014, there have been many publications on the role of PIEZO1 in endothelial function and its role in processes such as atherosclerosis, hypertension, cell-cell junctions, vascular permeability and leukocyte diapedesis. Read more

Platelets in health, ageing and disease: new diagnostics and treatments

Platelets are small blood cells that play a vital role in the chronic and acute progression of Cardiovascular Disease (CVD), and also have roles in immunity, inflammation, cancer metastasis, Alzheimer's disease and a range of infections, such as dengue, HIV-1, malaria, and COVID-19. Read more

Extracellular vesicles in health and disease

Endothelial dysfunction (ED) is associated with classical and emerging risk factors of cardiovascular disease (CVD), correlates with disease progression and is an independent predictor of the risk of future cardiovascular events. Read more

Cardiovascular and Neuromuscular Functions around the Clock: Harnessing Protective Endogenous Mechanisms towards Smarter Design of Novel Therapies and Interventions

Optimal tissue and organ is essential for long-term health and quality of life. One such important regulator within the body is related to circadian rhythms, which control ~24h cycles in many physiological processes such as sleep/wake cycles, physical activity/rest cycles, drug metabolism and hormones. Read more

Circadian mechanisms in psoriasis: therapeutic opportunities

Hallmark features of psoriasis symptoms vary through time, suggesting an important role for circadian circuits in driving disease expression, and offering the potential of chronotherapy. Read more

The INDICO-II Study – Effects of Body Composition and Dietary Improvement on Cell Membrane Dynamics and their Relationship with the Aetiology of Type II Diabetes

The InDiCo Study (Inflammation, Diets, body Composition) is a pre-clinical study conducted at the University of Worcester. The InDiCo Study is currently unravelling links between diets that favour a pro-inflammatory environment with biomarkers of cell function and body composition. Read more

Using CRISPR in iPS cells to modify platelet function

Project Overview. Platelets are the small cells in the blood whose job it is to prevent bleeding. Under normal conditions, when they encounter a damaged blood vessel they become activated and form a thrombus. Read more

Systems level analysis of platelet signalling

We are interested in how intracellular signal transduction networks bring about complex biological behaviours in cells. We do this by combining computational biology with wet laboratory experimentation. Read more

The BCAT1 CXXC Motif and Oncogenesis in Acute Myeloid Leukaemia

The BCAT1 gene is implicated in the pathogenesis of many cancer types, including acute myeloid leukaemia (AML)1–4. Recently, our group identified a novel antioxidant role for BCAT1 in AML cells5. Read more

Interdisciplinary investigation of the role of amino acids in immunometabolic responses to metformin in human cells

There is overwhelming evidence that inflammation contributes to the development of cardiovascular disease (CVD) but counterbalancing this is evidence from meta-analysis of randomised control trials that many existing anti-inflammatory drugs, such as COX2 inhibitors and anti-TNF drugs, tend if anything to exacerbate risk of CVD. Read more

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