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Cell Biology / Development (cell therapy) PhD Projects, Programs & Scholarships

We have 71 Cell Biology / Development (cell therapy) PhD Projects, Programs & Scholarships

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We have 71 Cell Biology / Development (cell therapy) PhD Projects, Programs & Scholarships

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A10 dopamine neurons: the missing link in cell therapeutics for Parkinson's disease?

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease and degeneration of the nigral dopamine neurons is a key pathological feature of the condition. Read more

Identification of novel cortical interneuron regulators implicated in neuropsychiatric disorders

Despite representing only ~20% of the entire neuronal population in the neocortex, the GABAergic (Gamma-Aminobutyric Acid) inhibitory interneurons play a pivotal role in most cortical functions. Read more

Cutting off the fuel supply to calcium pumps in pancreatic cancer: a novel therapeutic strategy

Background and Rationale. Pancreatic ductal adenocarcinoma (PDAC) has the poorest survival and limited treatment options. Therefore, the search for novel therapeutic targets and drugs designed to selectively kill PDAC cells must remain a central research strategy. Read more

Macrophage driven therapy resistance in AML: from macrophage subset characterisation to therapeutic targeting.

  Research Group: Molecular Mechanisms and Long Term Conditions
Reference. SHLS20065. Background. Acute Myeloid Leukaemia (AML) is a common blood cancer in adults; with its incidence increasing with age, AML cases are predicted to double by 2030. Read more

Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer

  Research Group: Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more

Assessing the impact of hormone therapy on bone cell function to better understand prostate cancer’s distinct tropism to the bone

Prostate cancer shows distinct tropism to the bone and 90% of men with metastatic prostate cancer have secondary bone tumours. Hormone therapy is the standard of care in advanced prostate cancer and reduces circulating androgen levels, to restrict tumour growth. Read more

Unravelling mechanisms of disease progression in Myeloproliferative Neoplasms

The Haematopoietic Stem Cell Biology (HSCB) Laboratory is focused on understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignancies. Read more

Unravelling mechanisms of disease progression in Myeloproliferative Neoplasms

The Haematopoietic Stem Cell Biology (HSCB) Laboratory is focused on understanding how the normal haematopoietic stem/progenitor hierarchy is disrupted during the development of myeloid malignancies. Read more

Regulation of asymmetric cell division in brain cancer stem cells

Glioblastoma is the most lethal brain cancer in adults. Its poor prognosis is a result of aggressive tumour growth, therapeutic resistance, and tumour heterogeneity at the cellular and genetic level. Read more

Cancer therapy endocytosis

This is a project which aims to investigate how tumours and normal tissue internalise drugs such as cancer therapy antibodies in real in vivo models and in patients. Read more

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