Cell Biology (inhibitor) PhD Projects, Programmes & Scholarships

We have 17 Cell Biology (inhibitor) PhD Projects, Programmes & Scholarships

Identifying Mechanisms of Tyrosine Kinase Inhibitor Resistance in Breast/Cervical Cancer (with emphasis on FGFR)

Kingston University Faculty of Health, Science, Social Care and Education

FGF signalling is implicated in cancer (e.g., breast and cervical cancer) susceptibility and progression, suggesting that this powerful developmental pathway is co-opted by cancer cells. Read more

Supervisor: Dr A Chioni

Year round applications PhD Research Project Competition Funded PhD Project (Students Worldwide)

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The role of vitamin D3 in treating skin cancer and preventing drug resistance

University of Bradford Faculty of Life Sciences

Research Group: Chemistry and Biosciences

During the last decade numerous studies have alluded to vitamin D. 3. playing a role in the prevention of cancer. Recent clinical trials looking at the potential role of vitamin D. Read more

Supervisors: Dr M Sutherland, Dr H Sheldrake, Dr S Kauser

Year round applications PhD Research Project Self-Funded PhD Students Only

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Preclinical testing of collagen synthesis inhibitors for fibrotic disease

University of Liverpool Institute of Ageing and Chronic Disease Department of Musculoskeletal Biology

Fibrotic disease is characterised by an excessive accumulation of collagen within tissues, which then impedes tissue function. Organ fibrosis specifically kidney fibrosis, liver fibrosis, cardiac fibrosis and lung fibrosis have limited treatment options, pose a huge clinical burden and are life-limiting diseases. Read more

Supervisor: Dr EG Laird

Year round applications PhD Research Project Self-Funded PhD Students Only

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Urokinase-plasminogen activator as a target to block osteoarthritic cartilage destruction

University of Liverpool Institute of Life Course and Medical Sciences

Osteoarthritis (OA) is one of the major causes of disability globally, which is particularly significant in an ageing population. Read more

Supervisor: Dr D Wilkinson

Year round applications PhD Research Project Self-Funded PhD Students Only

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Role of mechanical signals in a 3D human model of alveolar differentiation

Great Ormond Street Hospital for Children NHS Trust BRC Translational Research (Non-Clinical) PhD Studentships

Alveolar epithelial type I (AT1) and type II (AT2) cells are essential for normal lung function following birth. Abnormal differentiation of AT1 and AT2 cells during development results in pulmonary pathology with associated neonatal mortality and long-term morbidity. Read more

Supervisors: Dr S Loukogeorgakis, Dr F Michielin, Prof P De Coppi

15 May 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Investigation of novel protease-antiprotease imbalances associated with cystic fibrosis and the effect of CFTR correction.

Queen’s University Belfast School of Pharmacy

Cystic fibrosis (CF) is a progressive life-limiting airways disease that affects over 162,000 people worldwide. Read more

Supervisor: Prof L Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Selective targeting of furin for the treatment of fibrotic lung disease.

Queen’s University Belfast School of Pharmacy

Furin, a proprotein convertase has been established as a therapeutic target across several disease areas to include chronic airways diseases and infectious disease, such as COVID-19 (reviewed in our recent publication, Douglas et al, 2023). Read more

Supervisor: Prof L Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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Molecular Glues as Novel Tools for Tackling Big Challenges in Human Health

University of Leicester Department of Chemistry

Background. The need for new medicines is greater than ever because of an ageing population and the complex clinical challenges brought about by drug resistance and/or side effects. Read more

Supervisors: Dr RD Doveston, Prof S Macip

23 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

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Deciphering the effect of antibody-dependent cell phagocytosis and cytotoxicity (ADCC/ADCP) in the regulation of cross-presentation and antigen spreading in liver cancer.

University of Oxford Nuffield Department of Medicine

Primary liver cancers (hepatocellular carcinoma [HCC] and intrahepatic cholangiocarcinoma) are the fourth leading cause of malignancy-related mortality worldwide. Read more

Supervisors: Dr F Galvez-Cancino, Prof I Melero Bermejo

6 May 2024 PhD Research Project Funded PhD Project (Students Worldwide)

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Exploring the multi-organ benefits of Rapamune in relation to ageing physiology

University of Nottingham School of Life Sciences

PhD Description. Drug repurposing is an emerging avenue of research in the field of Geroscience; a field whose stated aim is to “accelerate research into the basic mechanisms driving ageing which could lead to improved clinical interventions”. Read more

Supervisor: Prof P Atherton

22 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

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Gaining mechanistic insights into Atrial Fibrillation: Bench to bedside approaches

University of Liverpool Department of Pharmacology and Therapeutics

Atrial fibrillation (AF) is a common arrhythmia with symptoms like irregular heart rate, palpitations, shortness of breath, tiredness, and dizziness. Read more

Supervisor: Dr RB Burton

1 July 2024 PhD Research Project Self-Funded PhD Students Only

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Is there a Role for Activated Akt in Palatogenesis?

University of Dundee Dental School

Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more

Supervisors: Dr S. J. Jones, Dr M Islam

30 June 2024 PhD Research Project Self-Funded PhD Students Only

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MSc by Research: Deciphering the role(s) of Cdk1 during oocyte meiosis

University of Dundee School of Life Sciences

Meiosis is a specialised type of cell division that produces haploid daughter cells known as gametes that are important for sexual reproduction. Read more

Supervisor: Dr F G Pelisch

Year round applications PhD Research Project Self-Funded PhD Students Only

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Short and long-distance communication in cancer: Feedback regulation of Ras signalling in tumourigenesis and cachexia

Cardiff University Cardiff School of Biosciences

Hamaratoglu Lab studies cell-cell signalling in development and tumourigenesis. We take advantage of outstanding genetic tools in Drosophila, and use larval imaginal discs as model epithelial organs. Read more

Supervisors: Dr F Hamaratoglu, Dr C Hogan

Year round applications PhD Research Project Self-Funded PhD Students Only

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Obtaining an integrated understanding of oncogenic RAS signalling

University of Leicester Molecular and Cell Biology

The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. The physiological importance of RAS signalling is evident as about 25% of all human cancers harbour mutations in ras genes, where kras is most frequently mutated (about 18%) (COSMIC, v94). Read more

Supervisor: Dr K Tanaka

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 17 Cell Biology (inhibitor) PhD Projects, Programmes & Scholarships

Cell Biology (inhibitor) PhD Projects, Programmes & Scholarships

We have 17 Cell Biology (inhibitor) PhD Projects, Programmes & Scholarships

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