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We have 13 Cell Biology (medicinal) PhD Projects, Programmes & Scholarships

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Cell Biology (medicinal) PhD Projects, Programmes & Scholarships

We have 13 Cell Biology (medicinal) PhD Projects, Programmes & Scholarships

An Interdisciplinary Approach to Developing of Macrocyclic Inhibitors of the MAPK Pathway

Supervisory Team: Prof Ali Tavassoli . Project Description. We are seekign an outstanding chemistry student with an interest in chemical biology to work on a project to develop cyclic peptide inhibitors of a protein-protein interaction that is heavily implicated in the development and growth of tumours. . Read more

Structural-guided PROTAC targeting of BMX to modulate apoptotic sensitivity in disease

What determines at the molecular level whether a cell lives or dies? Regulation of the cellular life–death switch is essential in healthy cells for normal foetal development and for the clearance of damaged cells. Read more

How to regulate plasticity in the brain

The Kwok Lab at the School of Biomedical Science invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Polysialyltransferases as a target in metastatic cancer

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more

Development of chemical tools and bioactive compounds to explore the importance of enzyme activity in cancer diseases

Diversity-oriented synthesis (DOS) is a modern chemical methodology, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression. Read more

Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more

Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more

MSc by Research: Glueing proteins together with small molecules

Recent advances from the Ciulli Lab and others have contributed to the establishment of a game-changing new modality of chemical intervention into biological system – one that moves beyond the state-of-the-art. Read more
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