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We have 10 Cell Biology (peptides) PhD Projects, Programmes & Scholarships

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Cell Biology (peptides) PhD Projects, Programmes & Scholarships

We have 10 Cell Biology (peptides) PhD Projects, Programmes & Scholarships

Unravelling the Intricacies of Stress Hormone Regulation

Project Overview. The proopiomelanocortin (POMC) pathway is a crucial signaling cascade involved in regulating various physiological processes, including our response to stress, metabolism, immune function, and pigmentation. Read more

An Interdisciplinary Approach to Developing of Macrocyclic Inhibitors of the MAPK Pathway

Supervisory Team: Prof Ali Tavassoli . Project Description. We are seekign an outstanding chemistry student with an interest in chemical biology to work on a project to develop cyclic peptide inhibitors of a protein-protein interaction that is heavily implicated in the development and growth of tumours. . Read more

Peptide-mediated nanocarrier drug delivery for enhanced brain targeting and treatment of inflammation

This project involves the study of nanoparticles and drug delivery to the brain. The student would be required to make and characterise novel nanoparticles from special lipid molecules of various compositions more suitable for blood-brain barrier (BBB) targeting. Read more

How does the dynamic intra-membrane aggregation of phage lysis proteins kill bacterial pathogens?

This is an interdisciplinary project. It will provide a unique opportunity to obtain training in a wide range of interdisciplinary skills, including protein engineering techniques, protein purification, atomic force microscopy, neutron reflection and scattering as well as molecular dynamics simulations. Read more

Using chemical-genetics to inhibit and characterise “undruggable” enzymes

The ability to inhibit kinases with small molecule drugs has transformed our understanding of signalling networks. It has allowed us to define the substrates and processes that each kinase controls, and to map how these enzymes cooperate within signalling pathways. Read more

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

Engineering extracellular vesicles/exosomes for the treatment of ocular disease

Extracellular vesicles, also referred to as exosomes, are membrane‐bound particles containing huge numbers of proteins as well as genetic material in the form of RNA (mRNA and miRNA). Read more

Development of novel lipid nanoparticles (LNPs) for targeted gene delivery to cancer cells

Applications are invited for a self-funded, 3 year full-time PhD project. The PhD will be based in the School of Pharmacy and Biomedical Science and will be supervised by Dr Roja Hadianamrei and Dr Sassan Hafizi. Read more
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