Cell Biology (wellcome) PhD Projects, Programmes & Scholarships

We have 18 Cell Biology (wellcome) PhD Projects, Programmes & Scholarships

The use of life course epidemiology to support the experimental characterisation of genetic variation

University of Bristol Bristol Medical School

Project Background. There has been a rapid expansion in the generation of genetic sequence data over the last decade. Understanding the potential relevance of genetic mutations to human health remains challenging. Read more

Supervisors: Prof N Timpson, Dr L Corbin, Dr BL Lam

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Identifying causal risk factors and outcomes of atopic dermatitis

University of Bristol Bristol Medical School

Rationale. Several traits such as cardiovascular disease[1] and mental health disorders[2] have been reported to be observationally associated with atopic dermatitis (AD). Read more

Supervisors: Dr A Budu-Aggrey, Dr L Paternoster

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Investigating the genetic architecture of orofacial cleft: A genome-wide association study using trio data and an investigation of parent of origin and mother-children interaction effects.

University of Bristol Bristol Medical School

Rationale. Orofacial clefts (OFCs) are the most prevalent craniofacial congenital disabilities globally, occurring at a frequency of 1 out of 700 newborns. Read more

Supervisors: Dr S Lewis, Dr E Stergiakouli, Prof H Cordell

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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An investigation of the causal relationship and genetic overlap between sleep traits and physical and mental health using Mendelian randomization

University of Bristol Bristol Medical School

Rationale. Sleep has long been known to play a role in physical and mental wellbeing and sleep disruption has been observed to co-occur with a number of health conditions including. Read more

Supervisors: Dr S Lewis, Dr MR Renteria, Dr HJ Jones

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Identifying causal risk factors for disease progression

University of Bristol Bristol Medical School

Rationale. Typical epidemiological studies aim to identify causal risk factors for onset of disease by comparing diseased cases with disease free controls. Read more

Supervisors: Dr L Paternoster, Prof G Davey-Smith, Dr A Hartley

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Causal risk factors and biological mechanisms for colorectal cancer risk

University of Bristol Bristol Medical School

Rationale. Diet and lifestyle are likely to play an important role in colorectal cancer risk; obesity, low levels of physical activity, red and process meat consumption and low intake of dietary fibre have all been shown to predict colorectal cancer risk. Read more

Supervisors: Dr S Lewis, Dr KT Tsilidis

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Identifying metabolic drivers of cancer development

University of Bristol Bristol Medical School

Rationale. Growing evidence suggests that cell extrinsic factors are key in modulating tumor progression. Metabolites are small molecules that act as sources of fuel and building blocks essential for cells and tissues when present at normal levels. Read more

Supervisors: Dr E Vincent, Dr CB Bull, Prof N Timpson

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Mendelian Randomisation for mediation analysis with multiple mediators: theory and applications

University of Bristol Bristol Medical School

Rationale. Many of an individual’s traits are observationally associated with their health outcomes. Understanding the relationships between these factors is critical to effective public health intervention. Read more

Supervisors: Dr E Sanderson, Dr R Daniel, Dr L Howe

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Evaluating the role of circulating proteins in cancer risk and progression using genetic and observational approaches

University of Bristol Bristol Medical School

Rationale. Circulating proteins play fundamental roles in biology and disease aetiology, including development of cancer, and are the direct targets of many drugs (1). Read more

Supervisors: Prof R Martin, Dr JY Yarmolinsky, Dr P Haycock

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Harnessing genetics of DNA methylation to elucidate molecular mechanisms underlying human phenotypes.

University of Bristol Bristol Medical School

Rationale. GWAS studies have discovered many genetic associations for traits and diseases, but it has been difficult to elucidate the functional consequences of these variants. Read more

Supervisors: Dr J Min, Prof C Relton, Prof J MIll, Dr E Hannon, Dr G Hemani, Prof T Gaunt, Dr B Heijmans, Dr J Bell

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Establishing and orienting causal relationships between sleep characteristics and reproductive function

University of Bristol Bristol Medical School

Rationale. A large body of literature from animal studies has highlighted the role of core clock genes in relation to reproductive function [1]. Read more

Supervisors: Dr R Richmond, Dr G Sharp, Prof D Lawlor

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Breastfeeding and big babies - lifecourse and genomics epidemiological approaches to disentangle cause and effect.

University of Bristol Bristol Medical School

Rationale. The World Health Organisation recommends exclusively breastfeeding for 6 months, but in the UK, only 1% of infants meet the guidelines (1). Read more

Supervisors: Dr L Zuccolo, Dr LJ Johnson, Dr L Howe, Dr C Borges

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Identifying causal pathways to disease using DNA methylation predicted blood traits.

University of Bristol Bristol Medical School

Project Background. Blood cell types have been implicated in pathogenesis of chronic diseases. Genome wide association studies have identified thousands of variants associated with blood trait variation. Read more

Supervisors: Dr J Min, Dr E Hannon, Prof J MIll

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Investigating the role of dietary fructose in the development of early-onset colorectal cancer

University of Bristol Bristol Medical School

Project Background. This project will investigate the role of fructose in the development of early-onset colorectal cancer (EOCRC) in adults <50 years. Read more

Supervisors: Dr E Vincent, Dr A Chambers, Dr R Richmond, Dr NM Murphy

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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Metabolomic characterisation of adiposity across the life course

University of Bristol Bristol Medical School

Project Background. There is evidence that adiposity, measured by body mass index (BMI), causally influences a range of health outcomes, but little understanding of the mechanisms driving BMI effects. Read more

Supervisors: Dr L Corbin, Prof N Timpson, Dr RT Tsang

Year round applications PhD Research Project Funded PhD Project (Students Worldwide)

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We have 18 Cell Biology (wellcome) PhD Projects, Programmes & Scholarships

Cell Biology (wellcome) PhD Projects, Programmes & Scholarships

We have 18 Cell Biology (wellcome) PhD Projects, Programmes & Scholarships

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