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Cell Biology / Development (php) PhD Projects, Programs & Scholarships

We have 39 Cell Biology / Development (php) PhD Projects, Programs & Scholarships

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  An improved C. elegans model of Alzheimer’s Disease to monitor neuronal signalling activity
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr P van Oosten-Hawle, Prof N Cohen, Dr S Clapcote
Application Deadline: 31 January 2020

Funding Type

PhD Type

Alzheimer’s Disease (AD) is one of the most common form of neurodegenerative diseases known today, affecting approximately 50 million people worldwide.
  Understanding amyloid aggregation mechanisms of alpha- and gamma synuclein in vitro and in vivo
  Research Group: BBSRC White Rose DTP
  Dr P van Oosten-Hawle, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

A key pathological hallmark of synucleopathies, including Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS), is the formation of cytotoxic alpha-synuclein and gamma-synuclein aggregates respectively, that lead to neuronal cell death.
  A 3D in vitro model of wound healing incorporating skin, nerves and immune cells
  Dr A M Rajnicek, Prof H M Wilson
Applications accepted all year round

Funding Type

PhD Type

Diabetes, paralysis, being bed ridden and other conditions can result in chronic wounds that fail to heal, with significant personal consequences for patients and an annual cost of £4.5-5.1 billion annually (Guest et al., 2015) to the National Health Service.
  Development of ex vivo tissue culture models for developing next-generation biomaterial scaffolds for acellular regenerative medicine.
  Prof I Gibson, Prof N Vargesson
Applications accepted all year round

Funding Type

PhD Type

Bone repair and regeneration can be influenced by various guidance cues, including pharmacological cues, hypoxia environment and chemical cues released from scaffolds [1-3].
  Using CRISPR genome editing to determine the effects of obesity and hypertension associated polymorphisms
  Dr A MacKenzie, Prof M Delibegovic
Applications accepted all year round

Funding Type

PhD Type

Introduction. There is now little doubt that morbid conditions such as obesity, cardiovascular disease and diabetes are mechanistically linked.
  Investigating how the levels of queuine, a novel micronutrient, are associated with human ageing and brain health
  Dr B Green, Prof G Hardiman
Application Deadline: 16 December 2019

Funding Type

PhD Type

Project details. Queuine is the only micronutrient that directly affects translation efficiency and accuracy in eukaryotes, with roles in metabolism and healthy-aging of the brain.
  Rewiring of host cell protein complexes by pathogen effectors - mass spectrometry-based methods and applications in infection biology
  Dr B Collins, Prof J Bengoechea, Dr G Schroeder
Application Deadline: 16 December 2019

Funding Type

PhD Type

Project details. Bacterial pathogens, such as Klebsiella pneumoniae and Legionella pneumophila, residing inside host immune cells such as macrophages, must subvert host cell defences in order to avoid destruction.
  Understanding Biofilm Formation in the Domain Archaea
  Dr J Megaw, Prof B Gilmore
Application Deadline: 16 December 2019

Funding Type

PhD Type

Project details. Biofilms - structured and organised microbial communities - represent one of the most successful forms of life.
  Interneuron Development in the Zebrafish Spinal Cord
  Dr K Lewis
Applications accepted all year round

Funding Type

PhD Type

The Lewis Lab moved to Syracuse University from Cambridge University in the UK in 2010.
  EASTBIO - An integrative approach to understanding the mechanobiology of liver regeneration
  Dr M Bernabeu, Prof N Henderson
Application Deadline: 5 January 2020

Funding Type

PhD Type

The liver has a unique ability to regenerate [1], however in many cases of chronic liver disease this regenerative capacity is overwhelmed.
  Precision Medicine DTP - Analyzing network formation during brain tumour initiation
  Dr D Sieger, Prof P Uhlén
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. High grade brain tumours (HGBTs) represent a complex and devastating disease and are posing an unmet clinical need. These tumours resist multi-modal therapies and survival times are only 15 months on average.
  Precision Medicine DTP - Comprehensive study of miRNAs biogenesis in human cancer
  Dr G Michlewski, Dr C Kutter
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. MicroRNAs (miRNAs) are short non-coding RNAs ~22 nt in length that function as important regulators of gene expression1.
  Precision Medicine DTP - Dissecting the biophysics of ocular transcription factors in vivo
  Research Group: MRC Human Genetics Unit
  Dr D Papadopoulos, Prof W Bickmore, Prof V Vukojevic
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Of the ~1,600 human TF genes, up to ~25% (~400 genes) are expected to be haploinsufficient with a plethora of them leading to developmental disorders1, underlining that transcription factor (TF) abundance (dosage) plays a major role during cell and tissue specification.
  Precision Medicine DTP - Harnessing plasticity to repair spinal cord injury
  Dr T Becker, Prof C G Becker, Prof A El Manira
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. After a spinal cord injury in the zebrafish, lost neurons are replaced and axonal connections re-established (Tsarouchas et al., 2018).
  Precision Medicine DTP - How do IFITM proteins regulate the Interferon Related DNA-damage Resistance Signature (IRDS) and clinical outcomes in cancers of high unmet clinical need?
  Dr R Sloan, Prof K Ball, Dr S Wilson
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Interferon Induced Transmembrane proteins (IFITMs) are a family of innate immune membrane proteins that can inhibit viral infection at cell entry (e.g.
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