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Cell Biology / Development (processing) PhD Projects, Programs & Scholarships

We have 32 Cell Biology / Development (processing) PhD Projects, Programs & Scholarships

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  Investigation of molecular mechanisms of Intellectual disability using human-brain organoids
  Dr E Kang, Dr D Berg
Application Deadline: 13 March 2020

Funding Type

PhD Type

Intellectual disability (ID) is a condition characterized by significant limitation in cognitive ability and adaptive behaviours with a disease onset before adulthood.
  RNA metabolism in response to cellular stress
  Dr P Grzechnik, Dr S Brogna
Application Deadline: 31 January 2020

Funding Type

PhD Type

The aim of the project is to understand roles for mRNA processing during the stress response in eukaryotic cells. Exposure to acute stress reduces cell viability or fitness and therefore immediate adaption is crucial for cell survival.
  Regulation of mitochondrial gene expression (On the University’s application portal, please select "PhD in Medical Science at the MRC Mitochondrial Biology Unit").
  Dr M Minczuk
Application Deadline: 30 June 2020

Funding Type

PhD Type

MRC Mitochondrial Biology Unit. The key objective of this PhD project is to study nuclear-encoded proteins involved in mitochondrial (mt-) RNA metabolism, in order to understand how their dysfunction is linked to human mitochondrial pathologies.
  (BBSRC DTP) Optimisation of heteromeric protein complex formation via co-ordinated mRNA localisation
  Prof M Ashe, Dr M Pool, Prof C M Grant
Application Deadline: 31 January 2020

Funding Type

PhD Type

RNA granules play key roles in cells controlling many aspects of mRNA fate. For instance, in response to stress the relocalisation of mRNAs to mRNA processing bodies (P-bodies) and stress granules facilitates the degradation or storage of unwanted or valuable mRNAs, respectively.
  LaNts in wound repair, stem cell activation and squamous cell carcinoma
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

The Laminin N terminus proteins (LaNts) are a relatively unstudied protein family that are related to netrins and laminins. To date there are only two publications and one preprint about the LaNt proteins in the literature which means there is a massive potential to do novel, ground breaking research in this area.
  Translating epigenetic control into novel cancer therapeutics
  Prof N La Thangue, Prof D Kerr
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. The retinoblastoma protein pRb is a key tumour suppressor that governs fundamental mechanisms in the G1 to S phase transition of the cell cycle.
  A novel silk biomaterial-based combinational approach to enhance axonal regrowth after spinal cord injury
  Dr W Huang, Prof C McCaig, Dr P Seib
Application Deadline: 13 March 2020

Funding Type

PhD Type

Spinal cord injury causes permanent and incurable functional impairment below the injure site. No single therapy has ever been successful, so a combined approach is much more likely to succeed.
  Determination of the function of inherited refractive error risk factor genes in the embryonic development of the eye.
  Prof L Erskine, Prof N Vargesson, Prof M Collinson
Application Deadline: 13 March 2020

Funding Type

PhD Type

Refractive errors, such as short-sightedness (myopia) and long-sightedness (hyperopia), are becoming epidemic, and in parts of southeast Asia around 80% of people have short-sight.
  Do rural-dwellers develop more aggressive breast and prostate cancer than those living in the city?
  Prof P Murchie, Dr Z Miedzybrodzka, Prof V Speirs, Dr R Vieira
Application Deadline: 13 March 2020

Funding Type

PhD Type

BACKGROUND.
  Identifying the determinants of tumour susceptibility to replication-inhibiting chemotherapy
  Prof A Donaldson, Dr S R Dundas
Application Deadline: 17 February 2020

Funding Type

PhD Type

Chromosome replication and maintenance are central for cell division, and derailment of these processes is a major cause of cancer.
  Impact of the immune landscape on androgen ablation therapy and progression to therapy-resistant disease
  Prof I McEwan, Prof H M Wilson, Dr S R Dundas
Application Deadline: 17 February 2020

Funding Type

PhD Type

Prostate cancer is the most commonly diagnosed cancer in men and is a leading cause of cancer related death. The androgen receptor is important for the development and function of the prostate gland and is a driver of prostate cancer progression and metastasis.
  Investigating a parasite-specific gene expression mechanism for the identification of novel anthelmintic drug targets
  Dr B Mueller, Dr J Pettitt, Dr B Connolly
Application Deadline: 13 March 2020

Funding Type

PhD Type

Nematode parasites remain a major cause of neglected human disease and make significant global impacts on the health of agriculturally important animals and plants.
  New approaches to treating metastatic bone disease in breast and prostate cancer
  Dr A Riemen, Prof V Speirs, Prof A Johnstone
Application Deadline: 17 February 2020

Funding Type

PhD Type

Bone is a common metastatic site for breast and prostate cancers. Once metastasised to bones, one-year survival for prostate cancer is 29% (4) compared with 59% for breast cancer.
  Telomere integrity: How do Replication Factor C-like complexes maintain telomere length?
  Dr T Kubota, Prof A Donaldson
Application Deadline: 13 March 2020

Funding Type

PhD Type

Telomeres, the ends of eukaryotic chromosomes, play an essential role in protecting linear DNA from degradation. Derailed telomere regulation causes genome instability and has been implicated in increased rates of cellular senescence and many diseases, including cancer.
  The effect of anaesthetic neurotoxicity on the development of adult neural stem cells
  Dr D Berg, Dr E Kang
Application Deadline: 13 March 2020

Funding Type

PhD Type

Although most neurons in the mammalian brain are generated during development, certain areas possess the capacity to generate new neurons throughout life.
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