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We have 34 Cell Biology (transcription) PhD Projects, Programmes & Scholarships

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Cell Biology (transcription) PhD Projects, Programmes & Scholarships

We have 34 Cell Biology (transcription) PhD Projects, Programmes & Scholarships

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Chromatin regulation of oncogenic transcription and replication stress: mechanism and functional implications in acute myeloid leukemia

University of Liverpool Institute of Systems, Molecular and Integrative Biology
This project focuses on the molecular mechanisms promoting acute myeloid leukaemia (AML), a disease of great unmet need. AML is an aggressive blood and bone marrow cancer characterized by abnormal proliferation and differentiation of myeloid cells. Read more
 Supervisors: Dr M Papamichos Chronakis, Prof D MacEwan, Dr A Kanhere
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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ROLE OF FOXO1 TRANSCRIPTION FACTOR IN B-CELL MALIGNANCIES

Masaryk University Faculty of Medicine
The project is focused on FoxO1 transcription factor and its role in the pathophysiology of chronic lymphocytic leukemia (CLL). Although the therapy of CLL has made several remarkable improvements, the disease still remains incurable. Read more
 Supervisor: Assoc Prof Marek Mraz
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis

Masaryk University Faculty of Medicine
Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. Read more
 Supervisor: Dr D Blažek
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Human Genetics, Genomics and Disease: Integrating fusion-proteins molecular signatures for advancing sarcoma diagnosis and therapy

University of Edinburgh College of Medicine and Veterinary Medicine
  Research Group: MRC Human Genetics Unit
Location. MRC Human Genetics Unit, University of Edinburgh, UK & Max Delbrück Center, Berlin, Germany. Supervisors. Dr Nezha Benabdallah, Dr Daria Bunina. Read more
 Supervisor: Dr NB Benabdallah
 19 May 2024  PhD Research Project  Competition Funded PhD Project (Students Worldwide)
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Transcriptional kinases in cancer and developmental disorders

University of Leicester Molecular and Cell Biology
Cyclin-dependent kinases (CDKs) are protein kinases performing essential functions in regulation of cell cycle and transcription. Read more
 Supervisor: Dr MT Tellier
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic mechanisms causing malignant transformation of B cells and plasma cells

University of Leeds Faculty of Medicine and Health
Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Read more
 Supervisor: Prof U Klein
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Nuclear and transcriptional dysregulations during cellular senescence

University of Leicester Molecular and Cell Biology
Cellular senescence, which is characterised by a proliferation arrest, is a driver of ageing (1). Several stresses can induce cellular senescence, including persistent DNA damage, telomere dysfunction, and oncogene activation. Read more
 Supervisors: Dr MT Tellier, Dr Y Markaki
 23 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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PhD studentship - Defining the mechanisms underpinning HIF-1 and HIF-2 dependent transcriptional specificity in hypoxia.

Newcastle University Biosciences Institute
Award summary. 100% of home tuition fees paid and annual living expenses of £18,622. Overview. The cellular response to low oxygen levels (hypoxia), is crucial for cell survival and identity. Read more
 Supervisor: Dr B Ortmann
 14 June 2024  PhD Research Project  Funded PhD Project (European/UK Students Only)
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Molecular mechanism of vimentin induced epithelial mesenchymal transition (EMT) and stemness in cancer cells

Queen Mary University of London Institute of Dentistry
Background. Most cancers are epithelial in origin and arise from a single progenitor cell, similar to an embryo, to become a clone of cells. Read more
 Supervisors: Prof A Waseem, Dr H Tummala, Dr F Flores-Borja
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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(MRC DTP CASE) Multiomic evaluation of differential drug response in metastatic breast cancers

The University of Manchester Faculty of Biology, Medicine and Health
Breast cancers are the most common cancers in women. Estrogen Receptor (ER) plays a major role in breast cancer growth. To stop the cancer from growing further, clinically successful ER-targeting therapies like Fulvestrant, etc were developed. Read more
 Supervisors: Dr S Nagarajan, Dr HH Harrison, Prof R Clarke, Dr I Iqbal
 13 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Investigating the role of RNA dependent DNA repair in childhood cancer

University of Dundee School of Medicine
Damage to our genetic material DNA is responsible for a wide range of human diseases including neurodegenerative diseases, haematological diseases, immune deficiencies, early ageing and cancers. Read more
 Supervisor: Prof K Hiom
 30 June 2024  PhD Research Project  Self-Funded PhD Students Only
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Cell-biological mechanisms mediating primary cilium mediated interpretation of Shh signalling during vertebrate neuronal differentiation

The University of Manchester Faculty of Biology, Medicine and Health
Newborn neurons undergo extensive morphological changes as they polarise to extend axons. In the developing spinal cord, newborn neurons extend axons towards their targets in response to cues from the surrounding tissues. Read more
 Supervisors: Dr R Das, Dr S Herbert
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and tumorigenesis

Masaryk University Faculty of Medicine
Doctoral study program. Life Sciences. Research area. RNA/nucleic acids research in health, cancer biology. CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development. Read more
 Supervisor: Dr D Blažek
 Year round applications  PhD Research Project  Funded PhD Project (Students Worldwide)
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Circadian mechanisms in psoriasis: therapeutic opportunities

The University of Manchester Faculty of Biology, Medicine and Health
Hallmark features of psoriasis symptoms vary through time, suggesting an important role for circadian circuits in driving disease expression, and offering the potential of chronotherapy. Read more
 Supervisors: Dr H Young, Dr I Iqbal, Prof D Ray
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Investigating intrinsic and extrinsic mechanisms driving plasticity in colorectal cancer metastasis

Queen Mary University of London Barts and The London School of Medicine and Dentistry
This CRUK-funded project will commence in September 2024 and has funding for 4 years. The successful candidate will be based at Barts Cancer Institute, Faculty of Medicine and Dentistry (FMD), Charterhouse Square in the City of London. Read more
 Supervisors: Dr M Efremova, Dr G Ficz
 24 May 2024  PhD Research Project  Funded PhD Project (Students Worldwide)
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