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Cell Biology / Development (transgenic) PhD Projects, Programs & Scholarships

We have 29 Cell Biology / Development (transgenic) PhD Projects, Programs & Scholarships

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  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Applications accepted all year round

Funding Type

PhD Type

Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  LaNts in wound repair, stem cell activation and squamous cell carcinoma
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

The Laminin N terminus proteins (LaNts) are a relatively unstudied protein family that are related to netrins and laminins. To date there are only two publications and one preprint about the LaNt proteins in the literature which means there is a massive potential to do novel, ground breaking research in this area.
  EASTBIO: Resistance in Crop Roots: Functional Analysis of the H2-Meditated Response to Nematodes
  Dr S Mantelin, Prof J Jones
Application Deadline: 5 January 2020

Funding Type

PhD Type

Resistance genes provide plants with protection against a range of pathogens. Despite their use in crop breeding programmes, our knowledge of how plant resistance genes function is still sketchy and mainly based on studies in leaves rather than roots.
  Dynamic Patterning Underlying Grass Organ Shape
  Research Group: Institute of Molecular Plant Sciences
  Dr A Richardson, Dr S Spoel
Application Deadline: 5 January 2020

Funding Type

PhD Type

Leaf and floral organ shape are intricately linked to plant productivity. In grass crops such as barley, this relationship between shape and productivity directly impacts on grain yield.
  Reprogramming stomatal behaviour to reduce water use in crops
  Prof L Sweetlove, Prof R G Ratcliffe
Application Deadline: 24 January 2020

Funding Type

PhD Type

Future food security will depend on developing crop plants that are as efficient as possible in their utilisation of finite resources such as water.
  Egr2 and 3 mediated T cell tolerance in cancer and their impact in immune checkpoint therapy
  Dr S Li
Applications accepted all year round

Funding Type

PhD Type

Tumour infiltrated lymphocytes (TILs) contain tumour reactive T cells and have been used as adoptive cell transfer therapy in patients which can mediate cancer regression.
  Investigating the role of MCL-1 in breast cancer stem cells
  Dr K Blyth, Dr K Campbell
Application Deadline: 3 January 2020

Funding Type

PhD Type

Annually, breast cancer accounts for over 11,000 deaths in the UK. We have found that high levels of MCL-1 (a pro-survival BCL-2 family member) at diagnosis predicts poor prognosis in breast cancer.
  Can improved genetic understanding of grain weight help feed the world? (UAUYJ20DTP)
  Dr C Uauy
Application Deadline: 25 November 2019

Funding Type

PhD Type

Wheat provides 20% of the calories and protein consumed by humans. The world population will reach 9 billion by 2050, which requires food production to more than double.
  Cellular cross-talk at the perivascular niche and the blood brain barrier
  Prof B Hogan
Applications accepted all year round

Funding Type

PhD Type

Much research on vasculature has focussed on the endothelial cells that line functional vessels, however the milieu of cells that surround vessels (mural cells) play important and under-appreciated roles in homeostasis and disease.
  The Hippo pathway and Yap1 in vascular growth control in development and disease
  Prof B Hogan, Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Lymphatic vessels play roles in the drainage of tissue fluid, trafficking of immune cells and the metastatic spread of cancer.
  Development of gene therapies for muscular dystrophies
  Dr L Popplewell
Applications accepted all year round

Funding Type

PhD Type

The activities in the Popplewell lab focus on the development of pre-clinical gene therapies for neuromuscular diseases, in particular muscular dystrophies based on gene replacement, endonuclease-mediated gene editing, antisense oligonucleotide (AO)-induced exon skipping and gene sliencing.
  Interneuron Development in the Zebrafish Spinal Cord
  Dr K Lewis
Applications accepted all year round

Funding Type

PhD Type

The Lewis Lab moved to Syracuse University from Cambridge University in the UK in 2010.
  (BBSRC DTP) Understanding the role of RNA binding proteins in the regulation of NF-kappa B dynamics, inflammation and cell death
  Prof M White, Dr A P Gilmore, Prof S Griffiths-Jones, Dr M Muldoon
Application Deadline: 31 January 2020

Funding Type

PhD Type

NF-kB is a key signalling system that controls inflammation and cell fate, dysregulation of which can lead to inflammatory disease or cancer.
  Function of miRNAs in formation and regeneration of human hair follicles
  Dr S Kurinna, Dr S Herrick, Prof R Paus
Applications accepted all year round

Funding Type

PhD Type

Recent advances in treating a severe skin condition with autologous transgenic keratinocyte cultures emphasises the importance of molecular mechanisms in selecting subpopulations of skin cells for cutaneous repair [1].
  Regulation of autophagy in human embryonic stem cells and its therapeutic application in induced pluripotent stem cell-based disease models
  Dr S Sarkar
Applications accepted all year round

Funding Type

PhD Type

Project background. Regulation of proteostasis is critical for maintaining tissue homeostasis. Autophagy, a major intracellular degradation pathway essential for cellular and energy homeostasis, functions in the clearance of aggregation-prone proteins and damaged organelles.
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