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Cell Biology / Development (3d) PhD Projects, Programs & Scholarships

We have 46 Cell Biology / Development (3d) PhD Projects, Programs & Scholarships

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Showing 1 to 30 of 46
  3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modelling and drug discovery
  Dr Y Y Lin, Dr J Connelly
Application Deadline: 29 February 2020

Funding Type

PhD Type

Applications are invited from highly motivated graduates with a BSc (First or Upper Second) or MSc (Distinction or Merit) from disciplines related to biomedical engineering, stem cell biology and regenerative medicine.
  Uncovering 3D genome architecture in annelid worms
  Dr JM Martin
Applications accepted all year round

Funding Type

PhD Type

The School of Biological and Chemical Sciences at Queen Mary is one of the UK’s elite research centres, according to the 2014 Research Excellence Framework (REF).
  Overcoming the barriers to brain delivery; bioengineering 3D printed microfluidic chips to continuous manufacture targeted nanoparticles and elucidate their nose to brain permeability
  Dr A Lalatsa, Prof A Butt, Dr A Bucchi
Application Deadline: 23 February 2020

Funding Type

PhD Type

Applications are invited for a fully-funded three-year PhD to commence in October 2020. This PhD studentship is1 of 6 PhD studentships funded by the University of Portsmouth in the area of biomaterials and bioengineering.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Creating 3D models of ARVC disease with light-induced tuneable severity in stem cell-derived cardiomyocytes
  Dr V GEORGE
Application Deadline: 27 February 2020

Funding Type

PhD Type

Applications are invited for a 3 year Non-Clinical BHF PhD studentship to work on the above project in Keele University, in the group of Dr.
  Using a novel 3D co-culture model to define metabolic flux maps of different cancer cell types in response to physical activity
  Dr M Morris, Dr A Islam, Prof M.P. Lewis
Applications accepted all year round

Funding Type

PhD Type

During exercise, and in the presence of sufficient oxygen, glucose is metabolised by muscle cells to produce pyruvate, a metabolic intermediate which is fed into the Kreb’s cycle in the mitochondria to produce large amounts of energy.
  A functional proteomic approach to reveal how receptor tyrosine kinases trafficking specifies cancer cell responses
  Dr C Francavilla, Prof S Hubbard
Applications accepted all year round

Funding Type

PhD Type

Background and goals. Cells respond appropriately to their surroundings by activating plasma membrane spanning receptors like Receptor Tyrosine Kinases (RTKs) and thereby adapting long-term outputs (e.g.
  Microtubule motors in cell migration and integrin trafficking
  Prof V Allan, Prof P Woodman, Dr P Caswell
Applications accepted all year round

Funding Type

PhD Type

Cell migration is vital for the development and health of multicellular organisms. However, enhanced cell migration is also a hallmark of cancer cells, and contributes greatly to metastasis.
  Tackling neurovascular dysfunction in dementia: a cell biology and biomaterials approach
  Prof N Hooper, Dr M Domingos, Dr T Wang
Applications accepted all year round

Funding Type

PhD Type

Neurovascular dysfunction is a central process in the pathogenesis of Alzheimer’s disease and other dementias. In the brain, vascular and neuronal structures are tightly integrated forming the multicellular neurovascular unit comprising endothelial cells, pericytes, astrocytes, microglia and neurons.
  Understanding and minimizing radiation damage in breast tissues
  Dr M Sherratt, Miss C Kirwan, Prof S Cartmell
Applications accepted all year round

Funding Type

PhD Type

Human beings are subjected to many forms of radiation both natural (principally ultraviolet radiation [UVR]) and artificial (diagnostic and therapeutic X-rays).
  An Organ on a Chip Platform for Biomedical Applications
  Dr P De Bank
Applications accepted all year round

Funding Type

PhD Type

Organ on a chip devices are an emerging technology which employ microfluidics to grow 3D tissues, mimicking the physiological conditions found in vivo.
  The functional characterization of the tumour suppressor gene CSMD1 in breast cancer
  Dr S Bell
Applications accepted all year round

Funding Type

PhD Type

CUB and Sushi multiple domains protein 1 (CSMD1) maps to 8p23, a region deleted in many cancers including breast cancer. Our previous work has established that CSMD1 is an independent prognostic marker in ductal breast cancer, with reduced expression associated with high tumour grade and poor survival1.
  LaNts and laminins in breast cancer
  Dr K Hamill
Applications accepted all year round

Funding Type

PhD Type

The laminins are a family of proteins that make up part of specialised regions of extracellular matrix termed basement membranes.
  ’Follow my leader’: in vitro studies of oral cancer cell motility
  Dr S Whawell, Dr H Colley
Applications accepted all year round

Funding Type

PhD Type

Oral cancer cell invasion is a crucial step in the progression of the disease and is mediated by interactions with the extra cellular matrix and factors released by the tumour cells as well as cells that occupy the tumour microenvironment (stroma).
  Characterisation of in vitro models of human salivary glands and their use in functional studies
  Dr L Bingle, Prof C Bingle
Applications accepted all year round

Funding Type

PhD Type

Saliva is produced by three pairs of major salivary glands and multiple minor glands in the lips, associated with the tongue and also with the palate.
  EPSRC Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine (LifETIME)

Funding Type

PhD Type

The CDT will train the next generation of leaders in developing in vitro tissues, sensing and diagnostics to develop humanised in vitro systems to drive better drug screening.
  Investigating the role of connexins in the gingival response to the oral microbiota
  Dr J Butcher, Dr C Wright, Dr P Martin
Applications accepted all year round

Funding Type

PhD Type

Project reference number. SHLS19005. Periodontal disease (PD) is a chronic inflammatory and bone destructive disease that imposes a substantial social and economic burden, and has been linked to the initiation and progression of cardiovascular disease, diabetes, rheumatoid arthritis, and Alzheimer’s disease.
  FGFR signalling in breast cancer
  Dr A Chioni
Applications accepted all year round

Funding Type

PhD Type

Growth factors are used during development to convey messages that tell cells to divide, survive, migrate and adopt a particular fate.
  Identification of the signalling networks that regulate Ciz1 levels, cellular proliferation and tumorigenesis
  Dr N Copeland, Dr S Allinson, Dr J Parsons
Application Deadline: 2 March 2020

Funding Type

PhD Type

This multidisciplinary PhD project, will develop the successful candidate through training in Lancaster University and Northwest Cancer Centre, at The University of Liverpool.
  Towards a Tissue Engineered Model of a Joint on a Chip
  Prof M.P. Lewis, Dr A Capel
Applications accepted all year round

Funding Type

PhD Type

This research project aims to develop a multi-tissue platform that integrates many of the structural tissue components of a musculoskeletal joint; bone, tendon, muscle, cartilage and ligament.
  Vascularisation of tissue engineered skeletal muscle
  Prof M.P. Lewis, Dr A Capel
Applications accepted all year round

Funding Type

PhD Type

Tissue engineering strategies have created a large number of functional tissues constructed from cells and matrix components over the past two decades.
  Simultaneous gene transcription and translation in bacteria
  Dr Gabriel Demo
Application Deadline: 20 February 2020

Funding Type

PhD Type

OBJECTIVES. The research aims to unravel the fundamental mechanism of the transcription-translation coupling in bacteria.
  EPSRC Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine (LifETIME)

Funding Type

PhD Type

The CDT will train the next generation of leaders in developing in vitro tissues, sensing and diagnostics to develop humanised in vitro systems to drive better drug screening.
  Modelling of Oral Neutrophil Epithelial interactions
  Dr E Hagi-Pavli
Applications accepted all year round

Funding Type

PhD Type

Background and Clinical Significance. Neutrophils are an important and vital cellular component of the innate immune system providing rapid protection against microbial invasion.
  The Impact Of Haemodynamics Generated In Mechanical Circulatory Support Devices On Primary Haemostasis Using A Blood-Shearing Device
  Dr J Pauls
Applications accepted all year round

Funding Type

PhD Type

The Critical Care Research Group (CCRG), based at the The Prince Charles Hospital (TPCH) in Brisbane, Australia, is seeking highly motivated, skilled and committed PhD candidates to join our multidisciplinary and international research team to commence a PhD project.
  (WIS) Deciphering escape from senescence in vivo
  Prof P Townsend, Prof A D Whetton
Application Deadline: 6 March 2020

Funding Type

PhD Type

Senescence is a dynamic cellular state characterised by a prolonged and generally irreversible cell-cycle arrest that promotes tissue remodelling but it can also have detrimental implications on regenerative capacities of tissues and conduce to inflammation and the progression of ageing-related disease including cancer.
  Building the human endometrium in vitro: The role of macrophages in receptive and decidual endometrium to optimise reproductive health
  Dr E Mann, Dr Peter Ruane, Prof J Aplin, Dr L Mohiyiddeen
Applications accepted all year round

Funding Type

PhD Type

The human endometrium is a highly dynamic tissue that rapidly generates over ~20 days and differentiates to form a uterus lining receptive to embryo implantation, further transforming into decidua to support embryonic development, or breaking down before regenerating a few days later.
  Identifying the role of glycosaminoglycans and microglia in early pathology of mucopolysaccharide diseases
  Prof B BIgger, Dr R Holley, Prof S Flitsch
Applications accepted all year round

Funding Type

PhD Type

Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by the deficiency of specific lysosomal enzymes required for the catabolism of glycosaminoglycans (GAGs) where each MPS type lacks a specific enzyme resulting in the build-up of GAGs in all cells of the body.
  Understanding the gene regulatory landscape of embryonic stem cells and cancer cells
  Prof A Sharrocks, Prof M Rattray
Applications accepted all year round

Funding Type

PhD Type

Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity.
  Bioactive Scaffolds for Tissue Engineering and Regenerative Medicine
  Dr P De Bank
Applications accepted all year round

Funding Type

PhD Type

Tissue engineering and regenerative medicine aim to either replace diseased or damaged tissue with a functional, laboratory-grown substitute, or stimulate the body’s own cells in order to promote repair.
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